Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation
This study demonstrates the capacity of the PARP inhibitor Olaparib to radiosensitize mutated chondrosarcoma cells to conventional photon irradiation and proton and carbon ion irradiation.Graphical abstract (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research
The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche in vivo
Conclusion: Our data provide evidence that homing of breast cancer cells is independent of their ER status and that the breast cancer bone metastasis niche is located within the trabecular region of bone, an area rich in osteoblasts and microvessels. The increased number of breast cancer cells homing to bone after mobilisation of HSCs suggests that the HSC and the bone metastasis niche overlap. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 14, 2019 Category: Cancer & Oncology Source Type: research
Anti-CD40 mAb enhanced efficacy of anti-PD1 against osteosarcoma
In this study, we established the osteosarcoma mouse tumor model resistant to anti-PD1 mAb that harbored PD1hi T cells. Furthermore, flow cytometry analysis of tumor infiltrating leukocytes after treatment was used as a screening platform to identify agents that could re-sensitize T cells to anti-PD1 mAb. Results showed that anti-CD40 mAb treatment converted PD1hi T cells to PD1lo T cells, reversing phenotypic T cell exhaustion and sensitizing anti-PD1 refractory tumors to respond to anti-PD1 mAb. Results also showed that intratumor Treg presented with a less activated and attenuated suppressive phenotype after anti-CD40 m...
Source: Journal of Bone Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research
The bone metastasis niche in breast cancer–potential overlap with the haematopoietic stem cell niche in vivo
Conclusion: Our data provide evidence that homing of breast cancer cells is independent of their ER status and that the breast cancer bone metastasis niche is located within the trabecular region of bone, an area rich in osteoblasts and microvessels. The increased number of breast cancer cells homing to bone after mobilisation of HSCs suggests that the HSC and the bone metastasis niche overlap. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 7, 2019 Category: Cancer & Oncology Source Type: research
Unplanned admissions for patients with myeloma in the UK: low frequency but high costs
ConclusionsMM is associated with a significant number of hospital admissions and NHS costs. The majority of the hospital admissions are elective, but the highest burden in terms of costs relates to unplanned admissions, with numbers increasing over time. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 7, 2019 Category: Cancer & Oncology Source Type: research
Have the difficulties and complications of surgical treatment for chondroblastoma of the adjoining knee joint been overestimated?
ConclusionsIntraregional aggressive curettage, phenolization, and allogeneic bone grafting are effective for treatment of chondroblastoma of the adjoining knee joint. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - May 14, 2019 Category: Cancer & Oncology Source Type: research
MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2
Publication date: Available online 11 May 2019Source: Journal of Bone OncologyAuthor(s): Haiyan Wang, Fangfang Zhao, Shanbao Cai, Youguang PuAbstractChemoresistance prevents curative potential of chemotherapy in most cases. MicroRNAs (miRNAs) are key players in regulating chemoresistance in osteosarcoma, which is the most common primary bone cancer. Bisulfite sequencing and quantitative real time PCR analyses showed that miR-193a expression is downregulated by DNA hypermethylation at its promoter region in a chemoresistant cell line, SJSA-1, compared to a chemosensitive cell line G-292. Introduction of a miR-193a mimi...
Source: Journal of Bone Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research
CXCR4 in human osteosarcoma malignant progression. The response of osteosarcoma cell lines to the fully human CXCR4 antibody MDX1338
Publication date: Available online 8 May 2019Source: Journal of Bone OncologyAuthor(s): Serena Pollino, Emanuela Palmerini, Barbara Dozza, Elisa Bientinesi, Martina Piccinni-Leopardi, Enrico Lucarelli, Alberto Righi, Maria Serena Benassi, Laura PazzagliaABSTRACTOsteosarcoma (OS) is the most frequent primary malignant tumour of bone and metastases occur in 30% of cases, the 5-year survival rate is 25-30%.Although pre- and post-operative chemotherapy has improved prognosis in osteosarcoma (OS), high toxicity and natural and acquired drug–resistance are the first cause of treatment failure. The identification of new predict...
Source: Journal of Bone Oncology - May 8, 2019 Category: Cancer & Oncology Source Type: research
Tumor derived EDIL3 modulates the expansion and osteoclastogenesis of myeloid derived suppressor cells in murine breast cancer model
Publication date: Available online 29 April 2019Source: Journal of Bone OncologyAuthor(s): Zhang Kun, Gao Xin, Wang Tao, Zhao Chenglong, Wang Dongsheng, Tang Liang, Liu Tielong, Xiao JianruAbstractEpidermal growth factor-like repeats and discoidin I like domain 3 (EDIL3) is an integrin ligand which is implicated in bone metabolism and bone marrow myelopoiesis. Recently, myeloid derived suppressor cells (MDSCs) as osteoclast progenitor have been demonstrated in several kinds of cancers including breast cancer. In this paper we explored the association between tumor derived EDIL3 and MDSCs in a murine breast cancer model. Kn...
Source: Journal of Bone Oncology - April 30, 2019 Category: Cancer & Oncology Source Type: research
RETRACTED: Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial
ConclusionsDenosumab is a safe but costly alternative to zoledronic acid for treatment of surgically unsalvageable giant cell tumor of bone.Graphical abstract (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 13, 2019 Category: Cancer & Oncology Source Type: research
Pelvic reconstruction following resection of tumour involving the whole ilium and acetabulum
ConclusionsThe procedure of femoral head autograft plus hemipelvic prosthesis was an effective method to reconstruct the defect following the whole ileum and the acetabulum resection; the functional outcomes were satisfactory, and it had an acceptable complication rate. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research
Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients
ConclusionThis finding potentially represents an additional mechanism of the bone-protective properties of tamoxifen and further emphasizes a link between Sema4D and estrogen receptor signaling. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 5, 2019 Category: Cancer & Oncology Source Type: research
Role of autophagy in osteosarcoma
Publication date: Available online 3 April 2019Source: Journal of Bone OncologyAuthor(s): Olivier Camuzard, Sabine Santucci-Darmanin, Georges F. Carle, Valérie Pierrefite-CarleAbstractOsteosarcoma (OS) is the most common primary bone tumour in children and adolescents. It is a highly aggressive tumor with a tendency to spread to the lungs, which are the most common site of metastasis. Advanced osteosarcoma patients with metastasis share a poor prognosis. Despite the use of chemotherapy to treat OS, the 5-year overall survival rate for patients has remained unchanged at 65-70% for the past 20 years. In addition, the 5-year...
Source: Journal of Bone Oncology - April 4, 2019 Category: Cancer & Oncology Source Type: research
Prognostic and clinicopathological significance of circulating tumor cells in osteosarcoma
Publication date: Available online 3 April 2019Source: Journal of Bone OncologyAuthor(s): Minghui Li, Yajie Lu, Zuoyao Long, Mengyang Li, Jing Kong, Guojing Chen, Zhen WangAbstractOsteosarcoma is the most common form of primary malignant bone tumor, with metastasis playing an essential role in determining a patient's prospects for survival. It is essential that new and better molecular targets that respond effectively to therapies and are predictive of the risk of tumor metastasis are identified. We have therefore undertaken the present prospective study to ascertain the clinical significance of circulating tumor cells (CT...
Source: Journal of Bone Oncology - April 4, 2019 Category: Cancer & Oncology Source Type: research
Pelvic reconstruction following resection of tumor involving the whole ilium and acetabulum
ConclusionsThe procedure of femoral head autograft plus hemipelvic prosthesis was an effective method to reconstruct the defect following the whole ileum and the acetabulum resection; the functional outcomes were satisfactory, and it had an acceptable complication rate. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - March 30, 2019 Category: Cancer & Oncology Source Type: research
