Irradiation enhanced the effects of PD-1 blockade in brain metastatic osteosarcoma
In this study, the mouse model of metastatic osteosarcoma to brain was used to explore the ability of local radiation and anti-PD-1 blockade to induce beneficial anti-tumor immune responses against distant, unirradiated brain metastatic tumors. Immune markers from the peripheral blood and tumor tissue were analyzed by flow cytometry, real-time PCR and western blot. The combination treatment produced a stronger systemic anti-tumor response than either treatment alone, shown by the reduced tumor burden and larger numbers of cytotoxic CD8+ T cells in the unirradiated tumors, indicating an abscopal effect. These data suggested...
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Diagnostic and prognostic values of blood microRNA-Let7A for osteosarcoma
ConclusionBlood microRNA-Let7A is a promising diagnostic and prognostic biomarker for osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Study on the relationship between livin expression and osteosarcoma
ConclusionLivin was highly expressed in osteosarcoma, and osteosarcoma Enncking staging and tumor size were positively correlated, both may be involved in the occurrence and development of osteosarcoma, and be closely related to the prognosis of osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
No consensus on implant choice for oligometastatic disease of the femoral head and neck
ConclusionsWhen treating metastatic lesions of the femoral head and neck orthopaedic oncologists do not agree on reconstructing with THA versus hemiarthroplasty for patients with younger age and favorable histology. This investigation highlights the controversy of this clinical decision and indicates the need for a collaborative prospective trial among this specific patient population in order to determine the optimal treatment method. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
A promoter variant of lncRNA GAS5 is functionally associated with the development of osteosarcoma
ConclusionsThe genetic variant rs145204276 is functionally associated with the susceptibility of OS, which can function as a protective factor in the incidence of OS possibly through the regulation of GAS5. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Bone metastases in biliary cancers: A multicenter retrospective survey
Publication date: September 2018Source: Journal of Bone Oncology, Volume 12Author(s): D Santini, G Brandi, G Aprile, M Russano, S Cereda, F Leone, S Lonardi, L Fornaro, M Scartozzi, N Silvestris, S Barni, F Pantano, B Vincenzi, A Palloni, G Frega, M Casagrande, L Ferrari, V Dadduzio, R Intini, R Filippi (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Outcomes and prognostic factors for surgically treated patients with breast cancer spine metastases
ConclusionsLymph node metastases and ER status are independent risk factors in predicting BCSM. Moreover, visceral metastasis, multiple metastases of the spine and post-op chemotherapy are independent prognostic factors. Luminal subtypes have higher rate, but late onset of spine metastases and prolonged survival. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma
ConclusionsThe association of variants of FASL and ABCC5 with survival outcome after chemotherapy was validated in patients with osteosarcoma. Our findings may provide a new insight into a more personalized treatment for patients with osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Trends in incidence of Ewing sarcoma of bone in India – Evidence from the National Cancer Registry Programme (1982–2011)
ConclusionThis paper has described population based measurements on burden and trends in incidence of skeletal Ewing in India. These may steer further research questions on the clinical and molecular epidemiology to explain factors associated with the increasing incidence of Ewing sarcoma bone observed in India. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations
Publication date: September 2018Source: Journal of Bone Oncology, Volume 12Author(s): Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R. Walkley, Agamemnon E. Grigoriadis, Dominique HeymannAbstractOsteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characte...
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
Publication date: September 2018Source: Journal of Bone Oncology, Volume 12Author(s): Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J. SuvaAbstractThe 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo. C57BL6/...
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Does intensified chemotherapy increase survival outcomes of osteosarcoma patients? A meta-analysis
ConclusionsIntensified chemotherapy might not be a preferred treatment for all of the osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China: A case-control study
ConclusionsCompared with surgery, LDC promotes more rapid recovery, is less invasive, is characterized by increased safety and a superior HRQOL, and is a more cost-effective treatment strategy for pediatric patients with SBL-LCH in the extremities. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Diagnostic and prognostic values of blood microRNA-Let7A for osteosarcoma
Conclusion Blood microRNA-Let7A is a promising diagnostic and prognostic biomarker for osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 27, 2018 Category: Cancer & Oncology Source Type: research
Irradiation enhanced the effects of PD-1 blockade in brain metastatic osteosarcoma
In this study, the mouse model of metastatic osteosarcoma to brain was used to explore the ability of local radiation and anti-PD-1 blockade to induce beneficial anti-tumor immune responses against distant, unirradiated brain metastatic tumors. Immune markers from the peripheral blood and tumor tissue were analyzed by flow cytometry, real-time PCR and western blot. The combination treatment produced a stronger systemic anti-tumor response than either treatment alone, shown by the reduced tumor burden and larger numbers of cytotoxic CD8+ T cells in the unirradiated tumors, indicating an abscopal effect. These data suggested...
Source: Journal of Bone Oncology - June 26, 2018 Category: Cancer & Oncology Source Type: research
