NPNT promotes early-stage bone metastases in breast cancer by regulation of the osteogenic niche
Publication date: November 2018Source: Journal of Bone Oncology, Volume 13Author(s): Dongsheng Wang, Chenglong Zhao, Liangliang Gao, Yao Wang, Xin Gao, Liang Tang, Kun Zhang, Zhenxi Li, Jing Han, Jianru XiaoAbstractPatients with breast cancer are often afflicted by bone metastases, while the establishment and growth of bone metastases depend on interaction between cancer cells and the host environment. Moreover, osteoblasts, which play a vital role in cancer cells survival and colonization, can form an osteogenic niche in early stage of bone metastases. Also, it is widely accepted that there is a genetic determinant during...
Source: Journal of Bone Oncology - October 4, 2018 Category: Cancer & Oncology Source Type: research
Prognostic and risk factors in patients with metastatic bone disease of an upper extremity
ConclusionsPatients with metastatic bone disease of an upper extremity have a limited life expectancy. The type of primary tumor and ECOG performance status were the important prognostic factors that influenced overall survival. Our data help in the management of patients, families, and doctors, so as to avoid over- or under-treatment. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - October 4, 2018 Category: Cancer & Oncology Source Type: research
Abnormally expressed long non-coding RNAs in prognosis of Osteosarcoma: A systematic review and meta-analysis
ConclusionsThis study demonstrated that abnormal LncRNAs expression might be potential prognostic markers to predict worse overall survival in osteosarcoma patients. However, the cut-off values may be the source of heterogeneity. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - October 4, 2018 Category: Cancer & Oncology Source Type: research
MolPharm/CABS 2018
Publication date: November 2018Source: Journal of Bone Oncology, Volume 13Author(s): (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - September 21, 2018 Category: Cancer & Oncology Source Type: research
Evaluation of short-term efficacy of extraspinal cementoplasty for bone metastasis: a monocenter study of 31 patients
Conclusion: Percutaneous cementoplasty of extraspinal bone metastasis is a rapidly efficient treatment with few adverse events. Its efficacy persists over time, with a benefit for disability and quality of life. Although this technique is only palliative, it should be considered in this situation. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - September 20, 2018 Category: Cancer & Oncology Source Type: research
Prognostic factors for patients with chondrosarcoma: a survival analysis based on the Surveillance, Epidemiology, and End Results (SEER) database (1973-2012)
Publication date: Available online 18 September 2018Source: Journal of Bone OncologyAuthor(s): Zhigang Nie, Qiang Lu, Hao PengAbstractCurrent reports on prognostic factors for chondrosarcoma mainly involve patients in treatment centers. Few are based on multicenter or multi-eras. We analyzed existing data from the Surveillance, Epidemiology, and End Results (SEER) database to investigate the risk factors for survival outcomes. All patients with chondrosarcoma from 1973 to 2012 were identified. 3737 patients were eligible and included. In survival analysis, patient had good survival outcome if the patient was female, young,...
Source: Journal of Bone Oncology - September 18, 2018 Category: Cancer & Oncology Source Type: research
Osteoblast Suppression In Multiple Myeloma Bone Disease
Publication date: Available online 15 September 2018Source: Journal of Bone OncologyAuthor(s): Juraj Adamik, Deborah L Galson, G David RoodmanAbstractMultiple myeloma (MM) is the most frequent cancer to involve the skeleton with patients developing osteolytic bone lesions due to hyperactivation of osteoclasts and suppression of BMSCs differentiation into functional osteoblasts. Although new therapies for MM have greatly improved survival, MM remains incurable for most patients. Despite the major advances in current anti-MM and anti-resorptive treatments that can significantly improve osteolytic bone lysis, many bone lesion...
Source: Journal of Bone Oncology - September 15, 2018 Category: Cancer & Oncology Source Type: research
β2ARs stimulation in osteoblasts promotes breast cancer cell adhesion to bone marrow endothelial cells in an IL-1β and selectin-dependent manner.
Publication date: Available online 8 September 2018Source: Journal of Bone OncologyAuthor(s): Lise Clément-Demange, Patrick L. Mulcrone, Troy Q Tabarestani, Julie A. Sterling, Florent ElefteriouAbstractProgression and recurrence of breast cancer, as well as reduced survival of patients with breast cancer, are associated with chronic stress, a condition known to impact the hypothalamic-pituitary axis and the autonomic nervous system. Preclinical and clinical evidence support the involvement of the sympathetic nervous system in the control of bone remodeling and in pathologies of the skeleton, including bone metastasis. In ...
Source: Journal of Bone Oncology - September 8, 2018 Category: Cancer & Oncology Source Type: research
Withdrawn:association of vitamin d receptor gene polymorphisms with osteosarcoma risk and prognosis
ConclusionOur results suggested that although polymorphisms of VDR gene are not related to the development of osteosarcoma, they may be important for prognosis. Understanding the effect of VDR polymorphisms on osteosarcoma will be important in identifying new prognostic parameters and new targets for treatment. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 19, 2018 Category: Cancer & Oncology Source Type: research
Exposure to Alendronate is Associated with a Lower Risk of Bone Metastases in Osteoporotic Women with Early Breast Cancer
Conclusions: History of alendronate use is associated with a lower likelihood of bone metastases in postmenopausal women with early breast cancer. Oral bisphosphonate treatment could be sufficient for reducing the risk of bone metastases. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 9, 2018 Category: Cancer & Oncology Source Type: research
Extracellular vesicles-Mediated Signaling in the Osteosarcoma Microenvironment: Roles and Potential Therapeutic Targets
In this study, the roles of EVs in the physiology and pathogenesis of OS and the potential attractive therapeutic target for the treatment of OS were reviewed. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 6, 2018 Category: Cancer & Oncology Source Type: research
Application of 3D-printed PEEK scapula prosthesis in the treatment of scapular benign fibrous histiocytoma: a case report
ConclusionsThe application of 3D-printed PEEK scapula prosthesis with total shoulder replacement offers the possibility of accurate reconstruction, improves the operability of surgery, shortens the operation time, and allows early functional recovery of the patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - August 2, 2018 Category: Cancer & Oncology Source Type: research
Association of vitamin d receptor gene polymorphisms with osteosarcoma risk and prognosis
ConclusionOur results suggested that although polymorphisms of VDR gene are not related to the development of osteosarcoma, they may be important for prognosis. Understanding the effect of VDR polymorphisms on osteosarcoma will be important in identifying new prognostic parameters and new targets for treatment. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 27, 2018 Category: Cancer & Oncology Source Type: research
Epidemiology of Benign Giant Cell Tumor of Bone in the Chinese Population
ConclusionsLeveraging unique population-based registry data, we estimated that GCT is a rare disease in the Chinese population with an incidence ranging between 1.49 and 2.57 cases per million persons per year. Possible differences in diagnostic classification of GCT, urban-rural demographics, and the younger demographic distribution of the Chinese population may underlie observations that GCT, a condition that primarily affects young individuals (20-40 years of age), accounts for a higher proportion of skeletal tumors in China than in other regions. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 26, 2018 Category: Cancer & Oncology Source Type: research
Isolation of circulating tumor cells in a preclinical model of osteosarcoma: effect of chemotherapy
This report highlights the biological interest of CTCs in osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 26, 2018 Category: Cancer & Oncology Source Type: research
