Trends in incidence of Ewing sarcoma of bone in India – Evidence from the National Cancer Registry Programme (1982–2011)
Conclusion This paper has described population based measurements on burden and trends in incidence of skeletal Ewing in India. These may steer further research questions on the clinical and molecular epidemiology to explain factors associated with the increasing incidence of Ewing sarcoma bone observed in India. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research
Does intensified chemotherapy increase survival outcomes of osteosarcoma patients? A meta-analysis
Conclusions Intensified chemotherapy might not be a preferred treatment for all of the osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research
Trends in incidence of Ewing sarcoma of bone in India - evidence from the National Cancer Registry programme (1982-2011)
Publication date: Available online 17 May 2018 Source:Journal of Bone Oncology Author(s): Debjit Chakraborty, Sukanya Rangamani, Vaitheeswaran Kulothungan, Meesha Chaturvedi, S. Stephen, Priyanka Das, Kondalli Lakshminarayana Sudarshan, Anish John, N. Manoharan, S.S. Koyande, Rajaraman Swaminathan, C. Ramesh, Atul Shrivastava, B. Ganesh, Prashant Mathur, Ambakumar Nandakumar (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - May 17, 2018 Category: Cancer & Oncology Source Type: research
Variants of FasL and ABCC5 are predictive of outcome after chemotherapy-based treatment in osteosarcoma
Conclusions The association of variants of FASL and ABCC5 with survival outcome after chemotherapy was validated in patients with osteosarcoma. Our findings may provide a new insight into a more personalized treatment for patients with osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - May 3, 2018 Category: Cancer & Oncology Source Type: research
Outcomes and prognostic factors for surgically treated patients with breast cancer spine metastases
Conclusions Lymph node metastases and ER status are independent risk factors in predicting BCSM. Moreover, visceral metastasis, multiple metastases of the spine and post-op chemotherapy are independent prognostic factors. Luminal subtypes have higher rate, but late onset of spine metastases and prolonged survival. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 14, 2018 Category: Cancer & Oncology Source Type: research
Bone metastases in biliary cancers: a multicenter retrospective survey
Publication date: Available online 7 April 2018 Source:Journal of Bone Oncology Author(s): Santini D, Brandi G, Aprile G, Russano M, Cereda S, Leone F, Lonardi S, Fornaro L, Scartozzi M, Silvestris N, Barni S, Pantano F, Vincenzi B, Palloni A, Frega G, Casagrande M, Ferrari L, Dadduzio V, Intini R, Filippi R, Vasile E, Vivaldi C, Faloppi L, Brunetti O, Reni M, Aglietta M, Tonini G (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - April 8, 2018 Category: Cancer & Oncology Source Type: research
Study on the relationship between livin expression and osteosarcoma
Conclusion : Livin was highly expressed in osteosarcoma, and osteosarcoma Enncking staging and tumor size were positively correlated, both may be involved in the occurrence and development of osteosarcoma, and be closely related to the prognosis of osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - March 15, 2018 Category: Cancer & Oncology Source Type: research
A promoter variant of lncRNA GAS5 is functionally associated with the development of osteosarcoma
Conclusions The genetic variant rs145204276 is functionally associated with the susceptibility of OS, which can function as a protective factor in the incidence of OS possibly through the regulation of GAS5. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research
Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations
Publication date: September 2018 Source:Journal of Bone Oncology, Volume 12 Author(s): Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R. Walkley, Agi E. Grigoriadis, Dominique Heymann Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characteris...
Source: Journal of Bone Oncology - March 6, 2018 Category: Cancer & Oncology Source Type: research
No Consensus on Implant Choice for Oligometastatic Disease of the Femoral Head and Neck
Conclusions When treating metastatic lesions of the femoral head and neck orthopaedic oncologists do not agree on reconstructing with THA versus hemiarthroplasty for patients with younger age and favorable histology. This investigation highlights the controversy of this clinical decision and indicates the need for a collaborative prospective trial among this specific patient population in order to determine the optimal treatment method. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 28, 2018 Category: Cancer & Oncology Source Type: research
Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations
Publication date: Available online 21 February 2018 Source:Journal of Bone Oncology Author(s): Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R. Walkley, Agamemnon E. Grigoriadis, Dominique Heymann Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and ...
Source: Journal of Bone Oncology - February 24, 2018 Category: Cancer & Oncology Source Type: research
Surgical Thyroparathyroidectomy Prevents Progression of 5TGM1 Murine Multiple Myeloma In Vivo
Publication date: Available online 23 February 2018 Source:Journal of Bone Oncology Author(s): Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J. Suva The 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo...
Source: Journal of Bone Oncology - February 24, 2018 Category: Cancer & Oncology Source Type: research
Murine models of bone sarcomas
Publication date: Available online 21 February 2018 Source:Journal of Bone Oncology Author(s): Camille Jacques, Nathalie Renema, Benjamin Ory, Carl R. Walkley, Agi E. Grigoriadis, Dominique Heymann Osteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characterised by a h...
Source: Journal of Bone Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research
Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China: A case-control study
Conclusions Compared with surgery, LDC promotes more rapid recovery, is less invasive, is characterized by increased safety and a superior HRQOL, and is a more cost-effective treatment strategy for pediatric patients with SBL-LCH in the extremities. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research
Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in predicting pathological response to preoperative super-selective intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the mandible
Conclusions These results concluded that SUVmax reduction rate can predict pathological complete response of preoperative super-selective intra-arterial CRT for advanced SCC of the mandible. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - February 15, 2018 Category: Cancer & Oncology Source Type: research
