Trends in incidence of Ewing sarcoma of bone in India – Evidence from the National Cancer Registry Programme (1982–2011)
ConclusionThis paper has described population based measurements on burden and trends in incidence of skeletal Ewing in India. These may steer further research questions on the clinical and molecular epidemiology to explain factors associated with the increasing incidence of Ewing sarcoma bone observed in India. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Irradiation enhanced the effects of PD-1 blockade in brain metastatic osteosarcoma
In this study, the mouse model of metastatic osteosarcoma to brain was used to explore the ability of local radiation and anti-PD-1 blockade to induce beneficial anti-tumor immune responses against distant, unirradiated brain metastatic tumors. Immune markers from the peripheral blood and tumor tissue were analyzed by flow cytometry, real-time PCR and western blot. The combination treatment produced a stronger systemic anti-tumor response than either treatment alone, shown by the reduced tumor burden and larger numbers of cytotoxic CD8+ T cells in the unirradiated tumors, indicating an abscopal effect. These data suggested...
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations
Publication date: September 2018Source: Journal of Bone Oncology, Volume 12Author(s): Camille Jacques, Nathalie Renema, Frederic Lezot, Benjamin Ory, Carl R. Walkley, Agamemnon E. Grigoriadis, Dominique HeymannAbstractOsteosarcoma, Ewing sarcoma and chondrosarcoma are the three main entities of bone sarcoma which collectively encompass more than 50 heterogeneous entities of rare malignancies. In contrast to osteosarcoma and Ewing sarcoma which mainly affect adolescents and young adults and exhibit a high propensity to metastasise to the lungs, chondrosarcoma is more frequently observed after 40 years of age and is characte...
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Surgical thyroparathyroidectomy prevents progression of 5TGM1 murine multiple myeloma in vivo
Publication date: September 2018Source: Journal of Bone Oncology, Volume 12Author(s): Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J. SuvaAbstractThe 5TGM1 multiple myeloma transplanted C57BL6/KaLwRij model recapitulates many disease features including monoclonal paraprotein production as well as the development of osteolytic bone lesions. Since a significant association between serum parathyroid hormone PTH variations, bone anabolism and myeloma progression in patients receiving proteasome inhibitors exists, this study investigated the effect of the PTH axis on murine myeloma development in vivo. C57BL6/...
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Study on the relationship between livin expression and osteosarcoma
ConclusionLivin was highly expressed in osteosarcoma, and osteosarcoma Enncking staging and tumor size were positively correlated, both may be involved in the occurrence and development of osteosarcoma, and be closely related to the prognosis of osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Does intensified chemotherapy increase survival outcomes of osteosarcoma patients? A meta-analysis
ConclusionsIntensified chemotherapy might not be a preferred treatment for all of the osteosarcoma patients. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Diagnostic and prognostic values of blood microRNA-Let7A for osteosarcoma
ConclusionBlood microRNA-Let7A is a promising diagnostic and prognostic biomarker for osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research
Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in real-world practice in six European countries
ConclusionDespite the large proportion of patients receiving BTAs in this study, some patients with BMs are still not receiving early treatment to prevent SREs or to manage pain. Improving physicians’ understanding of the role of BTAs and the importance of early treatment following BM diagnosis has the potential to improve patient care. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst
ConclusionsThe multi-disciplinary diagnostic method and diagnostic model based on predictive factors, i.e., age, the presence of pathologic fracture, and platelet, LDH, ALP and WBC levels, aided the differentiation of TOS and ABC. Smaller tumors and normal LDH levels were associated with better outcomes. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Small interfering RNA-mediated silencing of G-protein-coupled receptor 137 inhibits growth of osteosarcoma cells
ConclusionsThe results of this study highlight the crucial role of GPR137 in promoting osteosarcoma cell growth in vitro. GPR137 could serve as a potential therapeutic target against osteosarcoma. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Analysis of curative effect of I125 implantation combined with radiofrequency ablation in treating bone metastases
Publication date: June 2018Source: Journal of Bone Oncology, Volume 11Author(s): Qizhou Zhang, Kunyao Zhang, Bing Xie, Yimin Ren, Guoliang Li, Liping Zhang, Aijing Wang, Yang LiAbstractThe aims of this study were to investigate the clinical effects of I125 implantation combined with radiofrequency ablation in treating bone metastases (BM) and analyze its clinical application so as to provide better treatment protocols for the treatment of BM. A total of 63 BM patients were randomly divided into the I125 implantation group (CON, treated with I125 seeds alone, 33 patients) and the combination group (I125-MA, 30 patients) to ...
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Blockade of CCL2 enhances immunotherapeutic effect of anti-PD1 in lung cancer
This study was to analyze the correlation between MDSC subsets and CCL2 level in lung cancer model. G-MDSC and M-MDSC from the blood and parenchyma were analyzed by flow cytometry and western blot in the lung tumor model. CCL2 was detected by ELISA assay, real-time PCR, western blot and flow cytometry. Furthermore, the therapeutic effects of combination treatment combining CCL2 antagonist and anti-PD1 antibody were assessed. Results showed that MDSC subsets had a positive correlation with CCL2, suggesting CCL2 may attract MDSC into the parenchyma. Gene and protein expression of CCL2, as well as the CCL2 surface expression ...
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in predicting pathological response to preoperative super-selective intra-arterial chemoradiotherapy for advanced squamous cell carcinoma of the mandible
ConclusionsThese results concluded that SUVmax reduction rate can predict pathological complete response of preoperative super-selective intra-arterial CRT for advanced SCC of the mandible. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Long non-coding RNA ANRIL is associated with a poor prognosis of osteosarcoma and promotes tumorigenesis via PI3K/Akt pathway
ConclusionsUpregulated expression of ANRIL is associated with the tumor development and prognosis of OS. ANRIL may regulate the function of OS cells through the AKT pathway. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
Incidence, risk factors and prognostic characteristics of bone metastases and skeletal-related events (SREs) in breast cancer patients: A systematic review of the real world data
ConclusionsBM and SREs are common problems in non-trial breast cancer populations. Patient demographics, clinical stage, tumor pathological type, molecular receptors status are significantly risk factors for incidence of BM, SREs and the survival. The unique characteristics of BM and SREs in breast cancer patients should be taken into account in future randomized controlled trials, as to optimize individual treatment options and assure a maximally long good quality of life. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research
