Novel 3D-printed prosthetic composite for reconstruction of massive bone defects in lower extremities after malignant tumor resection
ConclusionsPatient-specific 3D-printed prostheses combined with β-TCP bioceramics and/or vascularized fibula provide an excellent option for reconstruction of massive bone defects after lower extremity malignant tumor extirpation. Short-term follow up showed promising clinical results in recovering lower limb function, promoting osseointegration and reducing complications. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - January 25, 2019 Category: Cancer & Oncology Source Type: research
Denosumab Versus Zoledronic Acid in Cases of Surgically Unsalvageable Giant Cell Tumor of Bone: A Randomized Clinical Trial
ConclusionsDenosumab is a safe but costly alternative to zoledronic acid for treatment of surgically unsalvageable giant cell tumor of bone.Graphical Abstract (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research
Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis
ConclusionsIn patients with only one bone containing a metastasis but no visceral metastasis, bones near the primary were more likely to be first metastasized. This may be a valuable clue to primary tumor sites in patients with cancers of unknown primaries. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research
Local Control and Vertebral Compression Fractures Following Stereotactic Body Radiotherapy for Spine Metastases
ConclusionsThis study demonstrated that spine SBRT with doses of 16–18 Gy promises good local control of disease with acceptable VCF rates. Lowest vertebral body collapse score, female gender, and>6 months of bisphosphonate use were significantly associated with longer FFS. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research
Incidence of skeletal-related events among multiple myeloma patients in the United States at oncology clinics: Observations from real-world data
In this study, a database of oncology electronic health records was linked to administrative claims data. Patients identified were aged ≥18 years and newly diagnosed with MM, had ≥1 clinic visit within 1 month of diagnosis, and ≥1 year of follow-up after diagnosis. The study period was January 1, 2011 to December 31, 2016. 343 patients were included, 35% of whom had a baseline history of any SRE. During a median follow-up of 25.7 months, 34% of patients experienced SREs after diagnosis. Median time to SRE was 167 days. Among patients experiencing an SRE, 68% had an SRE within the first year. The incidence rate of SRE...
Source: Journal of Bone Oncology - December 26, 2018 Category: Cancer & Oncology Source Type: research
Ewing Sarcoma of the Mobile Spine; Predictive Factors for Survival, Neurological Function and Local Control. A Scandinavian Sarcoma Group Study with a Mean Follow-up of 12 Years
Conclusion: Patients with ES of the mobile have a relatively favorable prognosis. Nonetheless, local recurrence rate is high for this group of patients for which local treatment mainly relies on definitive radiotherapy.Emergency decompressive surgery may increase the risk for local recurrence. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 26, 2018 Category: Cancer & Oncology Source Type: research
Allogenic γδ T cell and tumor cell fused vaccine for enhanced immunotherapeutic efficacy of osteosarcoma
Publication date: Available online 26 December 2018Source: Journal of Bone OncologyAuthor(s): Yitian Wang, Jian Zhu, Wei Yu, Junjie Wang, Kaishun Xia, Chengzhen Liang, Huimin TaoAbstractHuman γδ T cells have displayed the promising roles in cancer immunity through cytokine secretion and cytotoxic activity. Researches have implicated their principal characteristics as the antigen presentation cells. How to improve γδ T cells' immunotherapeutic effect as the cell vaccine is still a great challenge. Herein, we explore the human γδ T cell and tumor cell fused vaccine for enhanced immunotherapeutic efficacy of osteosarcom...
Source: Journal of Bone Oncology - December 26, 2018 Category: Cancer & Oncology Source Type: research
A real-world study assessing the use of bone-targeted agents and their impact on bone metastases in patients with prostate cancer treated in clinical practice in Europe
ConclusionsAlthough most patients with BMs receive a BTA, there remain a proportion of patients who are not receiving adequate treatment to prevent SREs or manage pain. Oncologists are more likely to adhere to clinical guidelines than urologists for the prescription of BTAs. Bone pain is common and undertreated. Increasing awareness of SRE prevention and bone pain management might improve patient care. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research
The need for bone biopsies in the diagnosis of new bone lesions in patients with a known primary malignancy: a comparative review of 117 biopsy cases
CONCLUSIONSThis study has found that 21.4% of newly identified bone lesions in patients with a single known malignancy were not clinically associated with their primary tumor. Furthermore, 3.4% of these were newly discovered malignant bone tumors. The presence of clinical symptoms was identified to be a significant factor affecting whether a new bone lesion was clinically linked to a patient's primary malignancy. It is therefore recommended that active biopsy should be performed on newly found bone lesions of patients with primary malignant tumors, especially on asymptomatic patients or those whose lesions are unidentified...
Source: Journal of Bone Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research
Managements of Giant Cell Tumor within the Distal Radius: a Retrospective Study of 58 Cases from a Single Center
ConclusionsTaken together, the radiographic presentations (soft-tissue extension and tumor size) are the strong prognostic predictors of local recurrence of GCTB in distal radius. In most tumors, an initial treatment with curettage remains feasible and first-choice, especially with the adjuvant denosumab. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 14, 2018 Category: Cancer & Oncology Source Type: research
Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome
ConclusionsLimb salvage results in better functional outcome compared with amputation. Biological reconstruction is more advocated than prosthetics replacement, and furthermore, autograft might be suggested to be the optimal reconstructive method with regard to better postoperative functional outcome and less major complications. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 12, 2018 Category: Cancer & Oncology Source Type: research
Surgical Outcomes of Extracorporeal Irradiation and Re-implantation in Extremities for High Grade Osteosarcoma: A retrospective cohort study and a systematic review of the literature
ConclusionsDiaphyseal resection and extracorporeal irradiation of intercalary re-implantation offer the most promising outcome among other type of reconstructions. Availability of graft, fewer structural complications, and biological permanence are advantages of this reconstruction method. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 10, 2018 Category: Cancer & Oncology Source Type: research
Surgical Options and Reconstruction Strategies for Bone Tumors of Distal Tibia: A Systematic Review of Complications and Functional Outcome
ConclusionsLimb salvage results in better functional outcome compared with amputation. Biological reconstruction is more advocated than prosthetics replacement, and furthermore, autograft might be suggested to be the optimal reconstructive method with regard to better postoperative functional outcome and less major complications. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - December 4, 2018 Category: Cancer & Oncology Source Type: research
Association of vitamin d receptor gene polymorphisms with osteosarcoma risk and prognosis
ConclusionOur results suggested that although polymorphisms of VDR gene are not related to the development of osteosarcoma, they may be important for prognosis. Understanding the effect of VDR polymorphisms on osteosarcoma will be important in identifying new prognostic parameters and new targets for treatment. (Source: Journal of Bone Oncology)
Source: Journal of Bone Oncology - November 30, 2018 Category: Cancer & Oncology Source Type: research
Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management
Publication date: Available online 6 November 2018Source: Journal of Bone OncologyAuthor(s): Stella D'Oronzo, Robert Coleman, Janet Brown, Francesco SilvestrisAbstractBone metastases (BM) are a common complication of cancer, whose management often requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with BM may still experience skeletal-related events and symptomatic skeletal events, with detrimental impact on quality of life and survival.A deeper knowledge of the mechanisms underlying the onset of lytic and sclerotic BM has been acquired in the last decades, leading to the development o...
Source: Journal of Bone Oncology - November 23, 2018 Category: Cancer & Oncology Source Type: research
