Japanese Journal of Clinical Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Prevalence and molecular characteristics of DNA mismatch repair deficient endometrial cancer in a Japanese hospital-based population
ConclusionsThis study provides useful information for management in patients with DNA mismatch repair endometrial cancer. Specifically, cancer surveillance as recommended in patients with Lynch syndrome might not be necessary in patients with germline variant of uncertain significance and Lynch-like syndrome and their relatives. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2020 Category: Cancer & Oncology Source Type: research

Barriers to end-of-life discussion with advanced cancer patient as perceived by oncologists, certified/specialized nurses in cancer nursing and medical social workers
ConclusionsBarriers impeding end-of-life discussion were factors related to patients and their families, and oncologists ’ close cooperation with nurses and medical social workers is important in providing emotional support for patients and families. To facilitate end-of-life discussion, it is important to share information on patients’ prognosis and goals for treatment among oncologists and other medical professi onals, as well as strengthen communication skill of these medical professions. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 26, 2020 Category: Cancer & Oncology Source Type: research

EML4-ALK, a potential therapeutic target that responds to alectinib in ovarian cancer
AbstractOvarian cancer is prone to recurrence and chemotherapy resistance. Ovarian tumours of some patients have been positive for anaplastic lymphoma kinase fusion gene expression (ALK+). Preclinical studies indicate that anaplastic lymphoma kinase inhibitor can suppress the growth of ovarian cancer cells and transplantation tumours. Here, we present a patient with metastatic ALK+ high-grade serous ovarian cancer that testing positive for EML4-ALK (microtubule-associated protein-like 4 gene, fused to the anaplastic lymphoma kinase gene), experienced dramatic benefit after administration of the anaplastic lymphoma kinase i...
Source: Japanese Journal of Clinical Oncology - August 26, 2020 Category: Cancer & Oncology Source Type: research

Hyperostosis frontalis interna by bone scintigraphy
A 70-years-old female with a past history of breast cancer underwent a [99mTc] Hydroxy-Diphosphonate (HDP)-bone-scintigraphy for staging. The examination revealed a symmetrically intense and diffuse radiotracer uptake in the skeleton with absent or diminished visualization of the genitourinary system (superscan pattern) (Fig. 1A), and a high and linear tracer uptake at the skull (Fig. 1A, arrow). Single-photon emission computed tomography/computed tomography (SPECT/CT) images showed the localized uptake only on the inner lamina of the frontal bones (Fig. 1B –D). No further examination was performed, so the malignancy cou...
Source: Japanese Journal of Clinical Oncology - August 25, 2020 Category: Cancer & Oncology Source Type: research

Stage III disease of ovarian, tubal and peritoneal cancers can be accurately diagnosed with pre-operative CT. Japan Clinical Oncology Group Study JCOG0602
ConclusionsPreoperative computed tomography staging in each institution can be the surrogate for surgico-pathological diagnosis in stage III disease of ovarian cancer patients undergoing neoadjuvant chemotherapy without diagnostic surgery, but reliability of diagnosis of stage IIIB disease is inadequate.Clinical trial registration: UMIN000000523(UMIN-CTR). (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 25, 2020 Category: Cancer & Oncology Source Type: research

Association between cancer immunity and treatment results in uterine cervical cancer patients treated with radiotherapy
ConclusionThe combination of CD8 or FoxP3 with EQD2 can be potentially useful to predict the treatment results of radiotherapy for cervical cancer, leading to individualized optimal selection of treatment for cervical cancer. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 25, 2020 Category: Cancer & Oncology Source Type: research

Overexpression of MUC16 (CA125) in extramammary Paget ’s disease
In this study, we identified the mucin-16 (CA125), a well-known disease marker for ovarian cancer, is overexpressed in the lesions of Extramammary Paget ’s disease. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 25, 2020 Category: Cancer & Oncology Source Type: research

Factors associated with suicidal ideation in patients with multiple myeloma
AbstractPatients with multiple myeloma are at risk of suicide. The study objective was to investigate the clinical risk factors of suicidal ideation among multiple myeloma patients. Consecutive inpatients with a new primary diagnosis of multiple myeloma were recruited. Patients were asked to complete the Patient Health Questionnaire-9 to measure suicidal ideation and depression. Patient demographic and biomedical characteristics (age, gender, education, marital status, employment, performance status and cancer stage) and pain and depression scores were analyzed as potential factors associated with suicidal ideation. Of the...
Source: Japanese Journal of Clinical Oncology - August 11, 2020 Category: Cancer & Oncology Source Type: research

Corrigendum to: Venous thromboembolism in cancer patients: report of baseline data from the multicentre, prospective Cancer-VTE Registry
The original Figure 2 published in this article mistakenly contained a duplicate of Figure 2A in the place of Figure 2B. This has now been corrected and the correct Figure 2B inserted. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 11, 2020 Category: Cancer & Oncology Source Type: research

Results from a 1-day workshop on the assessment of quality of life in cancer patients: a joint initiative of the Japan Clinical Oncology Group and the European Organisation for Research and Treatment of Cancer
This report summarizes the presentations and discussion in the first Japan Clinical Oncology Group-European Organisation for Research and Treatment of Cancer Quality of Life/Patient-Reported Outcome workshop funded by the National Cancer Center Hospital that was held on Saturday, 1 September 2018 in Tokyo, Japan. The infrastructure and understanding regarding the Quality of Life/Patient-Reported Outcome assessment of cancer patients in Japan is still immature, in spite of the increased demand for oncological Patient-Reported Outcome research felt not only by researchers but also by patients or other stakeholders of cancer ...
Source: Japanese Journal of Clinical Oncology - August 11, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of histological specimens obtained by two types of EBUS-TBNA needles: a comparative study
ConclusionCompared with stainless steel needles, cobalt chromium needle for EBUS-TBNA showed lower cartilage contamination and a higher ratio of obtaining diagnostic specimens in each sample. Bronchoscopists should consider using the optimal needle gauges and materials for collecting adequate specimens. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 11, 2020 Category: Cancer & Oncology Source Type: research

A prospective cohort study on the safety and efficacy of bevacizumab combined with chemotherapy in Japanese patients with relapsed ovarian, fallopian tube or primary peritoneal cancer
Conclusionbevacizumab combined with chemotherapy was tolerable and effective for Japanese patients with relapsed ovarian cancer, fallopian tube cancer or primary peritoneal cancer. Hypertension and proteinuria are frequently occurred and managed properly for continuing treatment. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research

Construction and validation of a prognostic nomogram for primary vulvar melanoma: a SEER population-based study
ConclusionsOur model was deemed to be a useful tool for predicting overall survival of vulvar melanoma with good discrimination and clinical applicability. We hoped this model would assist gynecologists in clinical decision and management of patients diagnosed with vulvar melanoma. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research

Prevalence and associated factors of perceived cancer-related stigma in Japanese cancer survivors
This study aimed to examine the prevalence and associated factors of perceived cancer-related stigma among Japanese cancer survivors. In this web-based survey involving 628 Japanese cancer survivors, perceived cancer-related stigma, quality of life (Quality of Life-Cancer Survivors Instrument), psychological distress (K6) and perceived social support (multidimensional scale of perceived social support) were evaluated. Perceived cancer-related stigma was endorsed by 61.2% of the participants. Perceived cancer-related stigma was significantly associated with quality of life (R = 0.35–0.37), psychological distress (R = ...
Source: Japanese Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research

Final results of a phase II study of nivolumab in Japanese patients with relapsed or refractory classical Hodgkin lymphoma
ConclusionNivolumab is effective and tolerable in Japanese relapsed or refractory classical Hodgkin lymphoma patients. Continued monitoring may be necessary to detect late-onset pulmonary toxicities.Clinical trial registrationJapicCTI-142755 (Japan Pharmaceutical Information Center). (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 8, 2020 Category: Cancer & Oncology Source Type: research