Cancer metabolism: New insights into classic characteristics
Publication date: Available online 29 September 2017 Source:Japanese Dental Science Review Author(s): Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh Baba Initial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant...
Source: Japanese Dental Science Review - September 30, 2017 Category: Dentistry Source Type: research
Molecular mechanisms of Porphyromonas gingivalis-host cell interaction on periodontal diseases
Publication date: Available online 9 August 2017 Source:Japanese Dental Science Review Author(s): Masaaki Nakayama, Naoya Ohara Porphyromonas gingivalis (P. gingivalis) is a major oral pathogen and associated with periodontal diseases including periodontitis and alveolar bone loss. In this review, we indicate that two virulence factors, which are hemoglobin receptor protein (HbR) and cysteine proteases “gingipains”, expressed by P. gingivalis have novel functions on the pathogenicity of P. gingivalis. P. gingivalis produces three types of gingipains and concomitantly several adhesin domains. Among the adhesin domai...
Source: Japanese Dental Science Review - August 9, 2017 Category: Dentistry Source Type: research
Neuropeptides and ATP signaling in the trigeminal ganglion
Publication date: Available online 15 March 2017 Source:Japanese Dental Science Review Author(s): Tetsuya Goto, Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka Peripheral nociceptive stimuli from orofacial structures are largely transmitted by the trigeminal nerve. According to the peripheral noxious stimuli, neurons in the trigeminal ganglion (TG) produce neuropeptides such as substance P, and calcitonin-gene-related peptide, etc. Beside the production of neuropeptides, there exists unique non-synaptic interaction system between maxillary and mandibular neurons in the TG. Neurons in the TG are surrounded by satellite ...
Source: Japanese Dental Science Review - March 14, 2017 Category: Dentistry Source Type: research
Epstein –Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity
Publication date: Available online 15 March 2017 Source:Japanese Dental Science Review Author(s): Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama Epstein–Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary...
Source: Japanese Dental Science Review - March 14, 2017 Category: Dentistry Source Type: research
Muscle power during intravenous sedation
Publication date: Available online 9 March 2017 Source:Japanese Dental Science Review Author(s): Nobuyuki Matsuura Intravenous sedation is effective to reduce fear and anxiety in dental treatment. It also has been used for behavior modification technique in dental patients with special needs. Midazolam and propofol are commonly used for intravenous sedation. Although there have been many researches on the effects of midazolam and propofol on vital function and the recovery profile, little is known about muscle power. This review discusses the effects of intravenous sedation using midazolam and propofol on both grip stre...
Source: Japanese Dental Science Review - March 9, 2017 Category: Dentistry Source Type: research
English education for healthcare professionals in Japan
This article will review the current status of English education for dental healthcare professionals in Japan. After conducting a literature search using the keywords: English education, Japan, and dental, only a few studies were found that investigated and proposed suggestions for dental professional English education. Even so, these were still in the early stages with outcomes yet to be fully evaluated. Even though English is thought indispensable for global professionals, and that increasing chances for communication skills is necessary, little attention has been addressed to English education for dental professionals o...
Source: Japanese Dental Science Review - March 2, 2017 Category: Dentistry Source Type: research
Thirst sensation and oral dryness following alcohol intake
Publication date: Available online 27 February 2017 Source:Japanese Dental Science Review Author(s): Kiyotoshi Inenaga, Kentaro Ono, Suzuro Hitomi, Ayu Kuroki, Izumi Ujihara Substantial acute and chronic intakes of alcohol or ethanol (EtOH) severely influence oral sensations, such as thirst and oral dryness (dry mouth, xerostomia). Thirst sensation and oral dryness are primarily caused by the activation of neurons in brain regions, including the circumventricular organs and hypothalamus, which are referred to as the dipsogenic center, and by a decrease in salivary secretion, respectively. The sensation of thirst exp...
Source: Japanese Dental Science Review - February 27, 2017 Category: Dentistry Source Type: research
The New Year has begun. Let ’s move forward!
Publication date: Available online 25 January 2017 Source:Japanese Dental Science Review Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - January 24, 2017 Category: Dentistry Source Type: research
Role of Streptococcus mutans two-component systems in antimicrobial peptide resistance in the oral cavity
Publication date: Available online 13 January 2017 Source:Japanese Dental Science Review Author(s): Miki Kawada-Matsuo, Hitoshi Komatsuzawa Approximately 100 trillion microorganisms exist in the oral cavity. For the commensal bacteria of the oral cavity, it is important to adapt to environmental stimuli, including human- or bacteria-derived antimicrobial agents. Recently, bacterial-specific signal transduction regulatory systems, called two-component systems (TCSs), which appear to be focused on sensing and adapting to the environment, were discovered. Streptococcus mutans is an oral commensal bacteria and is also know...
Source: Japanese Dental Science Review - January 12, 2017 Category: Dentistry Source Type: research
Therapeutic strategies with oral fluoropyrimidine anticancer agent, S-1 against oral cancer
Publication date: Available online 19 December 2016 Source:Japanese Dental Science Review Author(s): Koji Harada, Tarannum Ferdous, Yoshiya Ueyama Oral cancer has been recognized as a tumor with low sensitivity to anticancer agents. However, introduction of S-1, an oral cancer agent is improving treatment outcome for patients with oral cancer. In addition, S-1, as a main drug for oral cancer treatment in Japan can be easily available for outpatients. In fact, S-1 exerts high therapeutic effects with acceptable side effects. Moreover, combined chemotherapy with S-1 shows higher efficacy than S-1 alone, and combined che...
Source: Japanese Dental Science Review - December 19, 2016 Category: Dentistry Source Type: research
Ultrastructural and biochemical aspects of matrix vesicle-mediated mineralization
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Tomoka Hasegawa, Tomomaya Yamamoto, Erika Tsuchiya, Hiromi Hongo, Kanako Tsuboi, Ai Kudo, Miki Abe, Taiji Yoshida, Tomoya Nagai, Naznin Khadiza, Ayako Yokoyama, Kimimitsu Oda, Hidehiro Ozawa, Paulo Henrique Luiz de Freitas, Minqi Li, Norio Amizuka Matrix vesicle-mediated mineralization is an orchestrated sequence of ultrastructural and biochemical events that lead to crystal nucleation and growth. The influx of phosphate ions into the matrix vesicle is mediated by several proteins such as TNAP, ENPP1, Pit1,...
Source: Japanese Dental Science Review - November 4, 2016 Category: Dentistry Source Type: research
Presage of oncolytic virotherapy for oral cancer with herpes simplex virus
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Yoshiaki Yura A virus is a pathogenic organism that causes a number of infectious diseases in humans. The oral cavity is the site at which viruses enter and are excreted from the human body. Herpes simplex virus type 1 (HSV-1) produces the primary infectious disease, gingivostomatitis, and recurrent disease, labial herpes. HSV-1 is one of the most extensively investigated viruses used for cancer therapy. In principle, HSV-1 infects epithelial cells and neuronal cells and exhibits cytotoxicity due to its cytopathic effects...
Source: Japanese Dental Science Review - November 4, 2016 Category: Dentistry Source Type: research
The potential of enriched mesenchymal stem cells with neural crest cell phenotypes as a cell source for regenerative dentistry
Publication date: Available online 5 November 2016 Source:Japanese Dental Science Review Author(s): Kunimichi Niibe, Maolin Zhang, Kosuke Nakazawa, Satoru Morikawa, Taneaki Nakagawa, Yumi Matsuzaki, Hiroshi Egusa Effective regenerative treatments for periodontal tissue defects have recently been demonstrated using mesenchymal stromal/stem cells (MSCs). Furthermore, current bioengineering techniques have enabled de novo fabrication of tooth-perio dental units in mice. These cutting-edge technologies are expected to address unmet needs within regenerative dentistry. However, to achieve efficient and stable treatment...
Source: Japanese Dental Science Review - November 4, 2016 Category: Dentistry Source Type: research
The role of dentistry other than oral care in patients undergoing radiotherapy for head and neck cancer
Publication date: Available online 19 October 2016 Source:Japanese Dental Science Review Author(s): Hidenobu Matsuzaki, Kumiko Tanaka-Matsuzaki, Fuminobu Miyazaki, Hideki Aoyama, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Kengo Himei, Tetsuo Takeuchi, Tomoo Onoda, Yoshihiro Kimata, Jun-ichi Asaumi The usefulness of dental approaches, such as oral management, has gained recognition among patients treated for head and neck cancer. In particular, oral management plays a very important role before, during, and after treatment in patients undergoing radiotherapy, chemotherapy, or a combination of both. Howev...
Source: Japanese Dental Science Review - October 28, 2016 Category: Dentistry Source Type: research
Magnetic resonance and sonographic imagings of masticatory muscle myalgia in temporomandibular disorder patients
This article reviews recently published studies investigating the MRI and sonographic diagnosis of masticatory muscle myalgia in temporomandibular disorder patients. The MRI and sonographic features of muscle after treatment are also discussed. Literature published within the last 15 years was obtained from the PubMed database using the following Mesh terms: magnetic resonance imaging (MRI) or sonography, masticatory muscle pain, and treatment. MRI and sonography enable accurate visualization and evaluation of the masticatory muscles, thereby increasing our understanding of pathology and cause of pain associated with these...
Source: Japanese Dental Science Review - September 5, 2016 Category: Dentistry Source Type: research
