A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya LestariSummaryTooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odont...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Cancer metabolism: New insights into classic characteristics
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh BabaSummaryInitial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant p...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
The shape of progress
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masanori Kashimata, Toru HayashiSummaryBranching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial–mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) hav...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
The roles of odontoblasts in dental pulp innate immunity
Publication date: Available online 27 March 2018Source: Japanese Dental Science ReviewAuthor(s): Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi MatsuoSummaryOdontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbi...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery
This report presents an overview of currently available resorbable implant materials and their applications, with a focus on recent innovative advances and new developments in this field. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Uncovering the neural circuitry involved in the stress-attenuation effects of chewing
Publication date: Available online 6 April 2018Source: Japanese Dental Science ReviewAuthor(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu YamamotoAbstractPrevious animal studies have indicated that coupling restraint stress load with activation of the masticatory organs (chewing) causes a reduction in the systemic and central nervous system stress response. However, the brain mechanism underlying this effect is unknown. Therefore, in this review, we summarize the literature regarding brain regions involved in the attenuating effects of chewing and the systemic stress response attenuation effects induced by those brain re...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Wear of resin composites: Current insights into underlying mechanisms, evaluation methods and influential factors
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Akimasa Tsujimoto, Wayne W. Barkmeier, Nicholas G. Fischer, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A. Latta, Masashi MiazakiSummaryThe application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical success of re...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Implant treatment in ultra-aged society
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuji Sato, Noboru Kitagawa, Akio IsobeSummaryImplant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addresse...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Candida is a protractive factor of chronic oral ulcers among usual outpatients
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin KasuyaSummaryAlthough many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associat...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Histological and immunological characteristics of the junctional epithelium
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Masanori NakamuraSummaryThe continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of J...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi KuriharaSummaryPeriodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacteri...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Molecularly-targeted therapy for the oral cancer stem cells
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro NakajimaSummaryHuman cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research
Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Michiyo Matsumoto-NakanoSummaryStreptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to mo...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research
