Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - May 11, 2018 Category: Dentistry Source Type: research
Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery
This report presents an overview of currently available resorbable implant materials and their applications, with a focus on recent innovative advances and new developments in this field. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - April 6, 2018 Category: Dentistry Source Type: research
Uncovering the neural circuitry involved in the stress-attenuation effects of chewing
Publication date: Available online 6 April 2018 Source:Japanese Dental Science Review Author(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu Yamamoto Previous animal studies have indicated that coupling restraint stress load with activation of the masticatory organs (chewing) causes a reduction in the systemic and central nervous system stress response. However, the brain mechanism underlying this effect is unknown. Therefore, in this review, we summarize the literature regarding brain regions involved in the attenuating effects of chewing and the systemic stress response attenuation effects induced by those brain reg...
Source: Japanese Dental Science Review - April 6, 2018 Category: Dentistry Source Type: research
The roles of odontoblasts in dental pulp innate immunity
Publication date: Available online 27 March 2018 Source:Japanese Dental Science Review Author(s): Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of mic...
Source: Japanese Dental Science Review - March 27, 2018 Category: Dentistry Source Type: research
Implant treatment in ultra-aged society
Publication date: Available online 10 January 2018 Source:Japanese Dental Science Review Author(s): Yuji Sato, Noboru Kitagawa, Akio Isobe Implant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addr...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research
Candida is a protractive factor of chronic oral ulcers among usual outpatients
Publication date: Available online 12 January 2018 Source:Japanese Dental Science Review Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin Kasuya Although many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer a...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research
Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Publication date: February 2018 Source:Japanese Dental Science Review, Volume 54, Issue 1 Author(s): Masanori Kashimata, Toru Hayashi Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial–mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) have...
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research
The shape of progress
Publication date: February 2018 Source:Japanese Dental Science Review, Volume 54, Issue 1 Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - March 19, 2018 Category: Dentistry Source Type: research
Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
Publication date: Available online 15 December 2017 Source:Japanese Dental Science Review Author(s): Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi Kurihara Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier aga...
Source: Japanese Dental Science Review - December 16, 2017 Category: Dentistry Source Type: research
Molecularly-targeted therapy for the oral cancer stem cells
Publication date: Available online 16 December 2017 Source:Japanese Dental Science Review Author(s): Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro Nakajima Human cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognize...
Source: Japanese Dental Science Review - December 16, 2017 Category: Dentistry Source Type: research
Wear of resin composites: Current insights into underlying mechanisms, evaluation methods and influential factors
Publication date: Available online 11 December 2017 Source:Japanese Dental Science Review Author(s): Akimasa Tsujimoto, Wayne W. Barkmeier, Robert L. Erickson, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A. Latta, Masashi Miazaki The application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical succ...
Source: Japanese Dental Science Review - December 12, 2017 Category: Dentistry Source Type: research
Histological and immunological characteristics of the junctional epithelium
Publication date: Available online 7 December 2017 Source:Japanese Dental Science Review Author(s): Masanori Nakamura The continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of...
Source: Japanese Dental Science Review - December 8, 2017 Category: Dentistry Source Type: research
Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell –cell adhesion through N-cadherin
Publication date: Available online 9 November 2017 Source:Japanese Dental Science Review Author(s): Naoyuki Chosa, Akira Ishisaki Mesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC therap...
Source: Japanese Dental Science Review - November 10, 2017 Category: Dentistry Source Type: research
A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: Available online 7 October 2017 Source:Japanese Dental Science Review Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya Lestari Tooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odonto...
Source: Japanese Dental Science Review - October 7, 2017 Category: Dentistry Source Type: research
Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: Available online 29 September 2017 Source:Japanese Dental Science Review Author(s): Michiyo Matsumoto-Nakano Streptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to mod...
Source: Japanese Dental Science Review - September 30, 2017 Category: Dentistry Source Type: research
