International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exploring benzimidazole resistance in Haemonchus contortus by next generation sequencing and droplet digital PCR
Publication date: Available online 19 September 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Paulius Baltrušis, Peter Halvarsson, Johan HöglundAbstractAnthelmintic resistance in gastrointestinal nematode (GIN) parasites of grazing ruminants is on the rise in countries across the world. Haemonchus contortus is one of most frequently encountered drug-resistant GINs in small ruminants. This blood-sucking abomasal nematode contributes to massive treatment costs and poses a serious threat to farm animal health. To prevent the establishment of resistant strains of this parasite, up-to...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 20, 2018 Category: Parasitology Source Type: research

TRP channels as potential targets for antischistosomals
Publication date: Available online 8 September 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Swarna Bais, Robert M. GreenbergAbstractIon channels are membrane protein complexes that underlie electrical excitability in cells, allowing ions to diffuse through cell membranes in a regulated fashion. They are essential for normal functioning of the neuromusculature and other tissues. Ion channels are also validated targets for many current anthelmintics, yet the properties of only a small subset of ion channels in parasitic helminths have been explored in any detail. Transient receptor ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - September 9, 2018 Category: Parasitology Source Type: research

Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number
In conclusion, this study identified genetic changes associated with L. infantum resistance to allopurinol and the reduction in METK copy number identified may serve as a marker for resistance in dogs, and reduced protein activity correlated with increased allopurinol resistance.Graphical abstractDistribution of relative quantity values (RQ) of gene LinJ.30.3560 from the 20 L. infantum clinical strains in relation to their allopurinol IC50. (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 24, 2018 Category: Parasitology Source Type: research

Validation of Babesia proteasome as a drug target
Publication date: Available online 7 August 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Marie Jalovecka, David Hartmann, Yukiko Miyamoto, Lars Eckmann, Ondrej Hajdusek, Anthony J. O'Donoghue, Daniel SojkaAbstractBabesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Treatment of this emerging malaria-related disease has relied on antimalarial drugs and antibiotics. The proteasome of Plasmodium, the causative agent of malaria, has recently been validated as a target for anti-malarial drug development and therefore, in this study, we invest...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 8, 2018 Category: Parasitology Source Type: research

Modelling anthelmintic resistance by extending eggCounts package to allow individual efficacy
Publication date: Available online 3 August 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Craig Wang, Paul R. Torgerson, Ray M. Kaplan, Melissa M. George, Reinhard FurrerAbstractThe same anthelmintic treatment can have variable efficacy on individual animals even if the parasite population is homogenously susceptible. An extension of the R package eggCounts is proposed to take individual efficacy into account using a Bayesian hierarchical model. A simulation study is conducted to compare the performance of five different methods on estimating faecal egg count reduction and its unce...
Source: International Journal for Parasitology: Drugs and Drug Resistance - August 3, 2018 Category: Parasitology Source Type: research

Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis
In this study, 29 participating veterinary clinics received a total of 148 kits containing supplies for blood collection, dosing and prepaid shipping. Patients recruited after a diagnosis of heartworm infection were treated with a single standard dose of Advantage Multi® and a blood sample taken pre- and approximately 2–4 weeks post-treatment. Each sample was processed by performing a modified Knott's Test followed by isolation of microfilariae, genomic DNA extraction and MiSeq sequencing of regions encompassing 10 SNP sites highly correlated with ML resistance. We observed significant correlation of SNP loci frequencie...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 19, 2018 Category: Parasitology Source Type: research

Corrigendum to ‘the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities’ [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213–222]
Publication date: Available online 17 July 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Kathrin K. Geyer, Sabrina E. Munshi, Martin Vickers, Michael Squance, Toby J. Wilkinson, Daniel Berrar, Cristian Chaparro, Martin T. Swain, Karl F. Hoffmann (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 18, 2018 Category: Parasitology Source Type: research

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro
Publication date: Available online 4 June 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): H.M.P. Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L. McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill C.H. Chang, Anson V. Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B. GasserAbstractDue to widespread drug resistance in parasitic nematodes, there is a need develop new anthelmintics. Given the cost and time involved in developing a new drug, the repurposing of known chemicals can be a promising, alternative approach. In this ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota
This study highlights a strong relationship between tribendimidine and ivermectin administration and the gut microbiota and additional studies assessing the functional aspects as well as potential health-associated outcomes of these interactions are required.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. WenzlerAbstractTrypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses. Two drugs are available, diminazene and isometamidium, yet successful treatment is jeopardized by drug resistant T. congolense. Isothermal microcalorimetry is a highly sensiti...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
This study further reinforces the power of Cos-Seq approach to discover novel drug-resistance genes, some of which are life-stages specific.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

High level efficacy of lufenuron against sea lice (Lepeophtheirus salmonis) linked to rapid impact on moulting processes
We describe multiple experiments to characterize the efficacy of lufenuron on eggs, larvae, and parasitic stages of L. salmonis, and provide the most comprehensive assessment of the physiological responses of a marine arthropod to a benzoylurea chemical.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites
In this study, we assessed the activity of 42 compounds demonstrated or predicted (using virtual screening of a pharmacophore model) to bind/inhibit eukaryotic BDPs for activity against Plasmodium falciparum malaria parasites. In silico docking studies indicated that all compounds are predicted to participate in a typical hydrogen bond interaction with the conserved asparagine (Asn1436) of the P. falciparum histone acetyltransferase (PfGCN5) bromodomain and a conserved water molecule. Only one compound (the dimethylisoxazole SGC-CBP30; a selective inhibitor of CREBBP (CBP) and EP300 bromodomains) is also predicted to have ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Irene Fragiadaki, Anna Katogiritis, Theodora Calogeropoulou, Hans Brückner, Effie ScoulicaAbstractAnti-leishmanial treatment increasingly encounters therapeutic limitations due to drug toxicity and development of resistance. The effort for new therapeutic strategies led us to work on combinations of chemically different compounds that could yield enhanced leishmanicidal effect. Peptaibols are a special type of antimicrobial peptides that are able to form ion channels in cell membranes and pot...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Marta Martínez-García, Jean-Mathieu Bart, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M. Pérez-VictoriaAbstractThe parasitic protozoan Trypanosoma brucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance. Antimicrobial peptides have recent...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research