International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Plasmodium falciparum in  vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle
Publication date: December 2017 Source:International Journal for Parasitology: Drugs and Drug Resistance, Volume 7, Issue 3 Author(s): Sandra Duffy, Vicky M. Avery The continuous culture of Plasmodium falciparum is often seen as a means to an end, that end being to probe the biology of the parasite in question, and ultimately for many in the malaria drug discovery arena, to identify means of killing the parasite in order to treat malaria. In vitro continuous culture of Plasmodium falciparum is a fundamental requirement when undertaking malaria research where the primary objectives utilise viable parasites of a desired...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 22, 2017 Category: Parasitology Source Type: research

Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle
Publication date: Available online 15 July 2017 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Sandra Duffy, Vicky M. Avery The continuous culture of Plasmodium falciparum is often seen as a means to an end, that end being to probe the biology of the parasite in question, and ultimately for many in the malaria drug discovery arena, to identify means of killing the parasite in order to treat malaria. In vitro continuous culture of Plasmodium falciparum is a fundamental requirement when undertaking malaria research where the primary objectives utilise viable parasites of a desired lif...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 16, 2017 Category: Parasitology Source Type: research

Progressive increase in point mutations associates chloroquine resistance: Even after withdrawal of chloroquine use in India
This study elucidates the scenario of chloroquine efficacy at times that coincided with a new drug policy and especially assessed the chloroquine resistant molecular markers after withdrawal of chloroquine in Kolkata and Purulia, two malaria endemic zones of West Bengal, India. In vitro CQ susceptibility was tested in 781 patients with P. falciparum mono infections between 2008 and 2013, of which 338 patients had received CQ in 2008–2009. Genotyping of the pfcrt and the pfmdr1 gene was carried out in all isolates. Early treatment failure was detected in 114 patients {43 (31·39%) from Kolkata and 71 (35·32%) from Puruli...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 30, 2017 Category: Parasitology Source Type: research

Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum
This report shows the antileishmanial effect of several series of compounds (53), derived from podophyllotoxin (a natural cyclolignan isolated from rhizomes of Podophyllum spp.) and podophyllic aldehyde, on a transgenic, fluorescence-emitting strain of Leishmania infantum. These compounds were tested on both promastigotes and amastigote-infected mouse splenocytes, and in mammalian – mouse non-infected splenocytes and liver HepG2 cells – in order to determine selective indexes of the drugs. Results obtained with podophyllotoxin derivatives showed that the hydroxyl group at position C-7α was a structural requisite to ki...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 29, 2017 Category: Parasitology Source Type: research

Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren
Publication date: Available online 23 June 2017 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Jürgen Krücken, Kira Fraundorfer, Jean Claude Mugisha, Sabrina Ramüncke, Kevin C. Sifft, Dominik Geus, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Caritas Mukampunga, Claude Bayingana, Toni Aebischer, Janina Demeler, Jean Bosco Gahutu, Frank P. Mockenhaupt, Georg von Samson-Himmelstjerna Control of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resi...
Source: International Journal for Parasitology: Drugs and Drug Resistance - June 23, 2017 Category: Parasitology Source Type: research