International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
This study further reinforces the power of Cos-Seq approach to discover novel drug-resistance genes, some of which are life-stages specific.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs
Publication date: Available online 13 April 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Alberto Rastrojo, Raquel García-Hernández, Paola Vargas, Esther Camacho, Laura Corvo, Hideo Imamura, Jean-Claude Dujardin, Santiago Castanys, Begoña Aguado, Francisco Gamarro, Jose M. Requena Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures. No vaccines exist for human use, and the chemotherapeutic agents currently used are scanty. Furt...
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 14, 2018 Category: Parasitology Source Type: research

The prevalence of molecular markers of drug resistance in Plasmodium vivax from the border regions of Thailand in 2008 and 2014
Publication date: Available online 12 April 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Kritpaphat Tantiamornkul, Tepanata Pumpaibool, Jittima Piriyapongsa, Richard Culleton, Usa Lek-Uthai The prevalence of Plasmodium vivax is increasing in the border regions of Thailand; one potential problem confounding the control of malaria in these regions is the emergence and spread of drug resistance. The aim of this study was to determine the genetic diversity in genes potentially linked to drug resistance in P. vivax parasites isolated from four different border regions of Thaila...
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 13, 2018 Category: Parasitology Source Type: research

Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome ® and AmBisome® in murine cutaneous leishmaniasis
In conclusion, despite possibly being less safe and efficacious than A at equivalent doses, the moderate in vivo activity of F could indicate a role in the systemic pharmacotherapy of CL. Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 12, 2018 Category: Parasitology Source Type: research

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities.
This study demonstrates that the anti-fecundity activity of 5-AzaC affects more than just DNA methylation in schistosome parasites. Further characterisation of these processes may reveal novel targets for schistosomiasis control. Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - April 1, 2018 Category: Parasitology Source Type: research

Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites
In this study, we assessed the activity of 42 compounds demonstrated or predicted (using virtual screening of a pharmacophore model) to bind/inhibit eukaryotic BDPs for activity against Plasmodium falciparum malaria parasites. In silico docking studies indicated that all compounds are predicted to participate in a typical hydrogen bond interaction with the conserved asparagine (Asn1436) of the P. falciparum histone acetyltransferase (PfGCN5) bromodomain and a conserved water molecule. Only one compound (the dimethylisoxazole SGC-CBP30; a selective inhibitor of CREBBP (CBP) and EP300 bromodomains) is also predicted to have ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 26, 2018 Category: Parasitology Source Type: research

Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro
Publication date: Available online 20 March 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Irene Fragiadaki, Anna Katogiritis, Theodora Calogeropoulou, Hans Brückner, Effie Scoulica Anti-leishmanial treatment increasingly encounters therapeutic limitations due to drug toxicity and development of resistance. The effort for new therapeutic strategies led us to work on combinations of chemically different compounds that could yield enhanced leishmanicidal effect. Peptaibols are a special type of antimicrobial peptides that are able to form ion channels in cell membranes and po...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 21, 2018 Category: Parasitology Source Type: research

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time
Publication date: Available online 16 March 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. Wenzler Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses. Two drugs are available, diminazene and isometamidium, yet successful treatment is jeopardized by drug resistant T. congolense. Isothermal microcalorimetry is a highly sensi...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 17, 2018 Category: Parasitology Source Type: research

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
This study further reinforces the power of Cos-Seq approach to discover novel drug-resistance genes, some of which are life-stages specific. Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 17, 2018 Category: Parasitology Source Type: research

High level efficacy of lufenuron against sea lice (Lepeophtheirus salmonis) linked to rapid impact on moulting processes
We describe multiple experiments to characterize the efficacy of lufenuron on eggs, larvae, and parasitic stages of L. salmonis, and provide the most comprehensive assessment of the physiological responses of a marine arthropod to a benzoylurea chemical. Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 14, 2018 Category: Parasitology Source Type: research

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48
Publication date: Available online 12 March 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Marta Martínez-García, Bart Jean-Mathieu, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M. Pérez-Victoria The parasitic protozoan Trypanosoma brucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance. Antimicrobial peptides have ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 13, 2018 Category: Parasitology Source Type: research

Licochalcone A: An effective and low-toxicity compound against Toxoplasma gondii in vitro and in vivo
In conclusion, Lico A has strong anti-T. gondii activity in vitro and in vivo and might be developed into a new anti-T. gondii drug. Moreover, Lico A may exert these effects by interfering with lipid metabolism in the parasite. Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 2, 2018 Category: Parasitology Source Type: research

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
Publication date: Available online 1 March 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Arif Nurkanto, Ghulam Jeelani, Takehiro Yamamoto, Yoshiko Naito, Takako Hishiki, Mihoko Mori, Makoto Suematsu, Kazuro Shiomi, Tetsuo Hashimoto, Tomoyoshi Nozaki Coenzyme A (CoA), as a cofactor involved in >100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan parasite responsible for human amebiasis. We identified four key enzymes involved in ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 2, 2018 Category: Parasitology Source Type: research

Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites
Publication date: Available online 2 March 2018 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Patricia Vázquez, Luis Miguel Ferrer, Javier Blanco-Murcia, Javier Regidor-Cerrillo, Manuel Pizarro Díaz, Marta González-Huecas, Enrique Tabanera, Paula García-Lunar, Julio Benavides, Pablo Castaño, Andrew Hemphill, Matthew A. Hulverson, Grant R. Whitman, Kasey L. Rivas, Ryan Choi, Kayode K. Ojo, Lynn K. Barrett, Wesley C. Van Voorhis, Luis Miguel Ortega-Mora Neospora caninum is one of the main causes of abortio...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 2, 2018 Category: Parasitology Source Type: research

17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice
In this study, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an Hsp90 inhibitor, was evaluated for its inhibitory effect on five in vitro cultures of Babesia and Theileria species, including B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi, and on the multiplication of a B. microti–infected mouse model. 17-DMAG showed the inhibitory effect in all of the species tested. The half maximum inhibition concentration (IC50) of 17-DMAG on B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi was 77.6 ± 2.9, 62.4 ± 1.9, 183.8 ± 3.2, 88.5 ± 9.6, and 307.7 ± 7.2 nM, res...
Source: International Journal for Parasitology: Drugs and Drug Resistance - March 2, 2018 Category: Parasitology Source Type: research