International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Cristina Ballesteros, James F. Geary, Charles D. Mackenzie, Timothy G. GearyAbstractLymphatic filariasis and onchocerciasis are neglected parasitic diseases which pose a threat to public health in tropical and sub-tropical regions. Strategies for control and elimination of these diseases by mass drug administration (MDA) campaigns are designed to reduce symptoms of onchocerciasis and transmission of both parasites to eventually eliminate the burden on public health. Drugs used for MDA are pred...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Alberto Rastrojo, Raquel García-Hernández, Paola Vargas, Esther Camacho, Laura Corvo, Hideo Imamura, Jean-Claude Dujardin, Santiago Castanys, Begoña Aguado, Francisco Gamarro, Jose M. RequenaAbstractLeishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures. No vaccines exist for human use, and the chemotherapeutic agents currently used are scanty. Furthermore...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Differentially expressed genes in response to amitraz treatment suggests a proposed model of resistance to amitraz in R. decoloratus ticks
Publication date: December 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 3Author(s): Samantha Baron, Roberto A. Barrero, Michael Black, Matthew I. Bellgard, Ellie van Dalen, Christine Maritz-OlivierAbstractThe widespread geographical distribution of Rhipicephalus decoloratus in southern Africa and its ability to transmit the pathogens causing redwater, gallsickness and spirochaetosis in cattle makes this hematophagous ectoparasite of economic importance. In South Africa, the most commonly used chemical acaricides to control tick populations are pyrethroids and amitraz. The c...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 10, 2018 Category: Parasitology Source Type: research

Metabolism of albendazole, ricobendazole and flubendazole in Haemonchus contortus adults: Sex differences, resistance-related differences and the identification of new metabolites
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Lucie Raisová Stuchlíková, Petra Matoušková, Ivan Vokřál, Jiří Lamka, Barbora Szotáková, Anna Sečkařová, Diana Dimunová, Linh Thuy Nguyen, Marián Várady, Lenka SkálováAbstractHaemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite found in small ruminants, has a great ability to develop resistance to anthelmintic drugs. We studied the biotransformation of the three benzimidazole anthelmintics: albendazole (ABZ), ricobendazole (alb...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Arif Nurkanto, Ghulam Jeelani, Takehiro Yamamoto, Yoshiko Naito, Takako Hishiki, Mihoko Mori, Makoto Suematsu, Kazuro Shiomi, Tetsuo Hashimoto, Tomoyoshi NozakiAbstractThe Coenzyme A (CoA), as a cofactor involved in>100 metabolic reactions, is essential to the basic biochemistry of life. Here, we investigated the CoA biosynthetic pathway of Entamoeba histolytica (E. histolytica), an enteric protozoan parasite responsible for human amebiasis. We identified four key enzymes involved in the CoA pa...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Marion David, Chantal Lebrun, Thomas Duguet, Franck Talmont, Robin Beech, Stéphane Orlowski, François André, Roger K. Prichard, Anne LespineAbstractHaemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overcoming this resistance. In the model nematode, Caenorhabditis elegans, P-glycoprotein-13 is expresse...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Madhu Sundaraneedi, Ramon M. Eichenberger, Rafid Al-Hallaf, Dai Yang, Javier Sotillo, Siji Rajan, Phurpa Wangchuk, Paul R. Giacomin, F. Richard Keene, Alex Loukas, J. Grant Collins, Mark S. PearsonAbstractOver 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations. We investigated the anti-nematode efficacy of a series of polypyridylruthenium(II) complex...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Frederick A. Partridge, Anwen E. Brown, Steven D. Buckingham, Nicky J. Willis, Graham M. Wynne, Ruth Forman, Kathryn J. Else, Alison A. Morrison, Jacqueline B. Matthews, Angela J. Russell, David A. Lomas, David B. SattelleAbstractParasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global t...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Motility in the L3 stage is a poor phenotype for detecting and measuring resistance to avermectin/milbemycin drugs in gastrointestinal nematodes of livestock
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Melissa M. George, Lorraine Lopez-Soberal, Bob E. Storey, Sue B. Howell, Ray M. KaplanAbstractMotility is a commonly used in vitro phenotype for assessing anthelmintic activity of candidate compounds, and for detecting anthelmintic resistance in nematodes. Third-stage larvae (L3) of parasitic nematodes are commonly used in motility-based assays because L3 are simple to obtain and can remain viable in storage for extended periods. To improve the measurement of motility of microscopic stages of n...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Andreas Martin Lisewski, Joel Patrick Quiros, Monica Mittal, Nagireddy Putluri, Arun Sreekumar, Jesper Z. Haeggström, Olivier LichtargeAbstractIn the human malaria parasite Plasmodium falciparum, membrane glutathione S-transferases (GST) have recently emerged as potential cellular detoxifying units and as drug target candidates with the artemisinin (ART) class of antimalarials inhibiting their activity at single-digit nanomolar potency when activated by iron sources such as cytotoxic hematin. ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Melanie Abongwa, Djordje S. Marjanovic, James G. Tipton, Fudan Zheng, Richard J. Martin, Sasa M. Trailovic, Alan P. RobertsonAbstractZolvix® is a recently introduced anthelmintic drench containing monepantel as the active ingredient. Monepantel is a positive allosteric modulator of DEG-3/DES-2 type nicotinic acetylcholine receptors (nAChRs) in several nematode species. The drug has been reported to produce hypercontraction of Caenorhabditis elegans and Haemonchus contortus somatic muscle. We i...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs
In this study, we characterized the primary biochemical features of the C. parvum glucose-6-phosphate isomerase (CpGPI) and determined its Michaelis constant towards fructose-6-phosphate (Km = 0.309 mM, Vmax = 31.72 nmol/μg/min). We also discovered that ebselen, an organoselenium drug, was a selective inhibitor of CpGPI by high-throughput screening of 1200 known drugs. Ebselen acted on CpGPI as an allosteric noncompetitive inhibitor (IC50 = 8.33 μM; Ki = 36.33 μM), while complete inhibition of CpGPI activity was not achieved. Ebselen could also inhibit the growth of C. parvum in vitro (EC50 =�...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Gregory D. Bowden, Kirkwood M. Land, Roberta M. O'Connor, Heather M. FritzAbstractThe apicomplexan parasite Sarcocystis neurona is the primary etiologic agent of equine protozoal myeloencephalitis (EPM), a serious neurologic disease of horses. Many horses in the U.S. are at risk of developing EPM; approximately 50% of all horses in the U.S. have been exposed to S. neurona and treatments for EPM are 60–70% effective. Advancement of treatment requires new technology to identify new drugs for EP...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Synthesis of aminophenylhydroxamate and aminobenzylhydroxamate derivatives and in vitro screening for antiparasitic and histone deacetylase inhibitory activity
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): C. Loeuillet, B. Touquet, B. Oury, N. Eddaikra, J.L. Pons, J.F. Guichou, G. Labesse, D. SerenoAbstractA series of aminophenylhydroxamates and aminobenzylhydroxamates were synthesized and screened for their antiparasitic activity against Leishmania, Trypanosoma, and Toxoplasma. Their anti-histone deacetylase (HDAC) potency was determined. Moderate to no antileishmanial or antitrypanosomal activity was found (IC50 > 10 μM) that contrast with the highly efficient anti-Toxoplasma activity (I...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Bruno Levecke, Alice V. Easton, Piet Cools, Marco Albonico, Shaali Ame, John S. Gilleard, Jennifer Keiser, Antonio Montresor, Roger Prichard, Johnny Vlaminck, Jozef VercruysseAbstractThe egg reduction rate (ERR) is the current standard mean to assess the efficacy of drugs against human soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworm). Although the timing of post-treatment sampling is pivotal for a readily interpretation of drug efficacy, there is lack em...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research