International Journal for Parasitology: Drugs and Drug Resistance This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

P-glycoprotein-9 and macrocyclic lactone resistance status in selected strains of the ovine gastrointestinal nematode, Teladorsagia circumcincta
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Frank Turnbull, Nicholas N. Jonsson, Fiona Kenyon, Philip J. Skuce, Stewart A. BissetAbstractThe Teladorsagia circumcincta P-glycoprotein-9 (Tci-pgp-9) gene has previously been implicated in multiple-anthelmintic resistance in this parasite. Here we further characterise genetic diversity in Tci-pgp-9 and its possible role in ivermectin (IVM) and multi-drug resistance using two UK field isolates of T. circumcincta, one susceptible to anthelmintics (MTci2) and the other resistant to most availabl...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series
ConclusionsThe new lead series were shown to have cidal pharmacodynamic activity. The absence of cross-resistance with any of the current antileishmanial drugs opens possibilities for combination treatment to reduce the likelihood of treatment failures and drug resistance.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes
This study facilitates GPCR research in the liver fluke, Fasciola hepatica, by generating the first profile of GPCRs from the F. hepatica genome. Our dataset describes 147 high confidence GPCRs, representing the largest cohort of GPCRs, and the largest set of in silico ligand-receptor predictions, yet reported in any parasitic helminth. All GPCRs fall within the established GRAFS nomenclature; comprising three glutamate, 135 rhodopsin, two adhesion, five frizzled, one smoothened, and one secretin GPCR. Stringent annotation pipelines identified 18 highly diverged rhodopsins in F. hepatica that maintained core rhodopsin sign...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice
In this study, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an Hsp90 inhibitor, was evaluated for its inhibitory effect on five in vitro cultures of Babesia and Theileria species, including B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi, and on the multiplication of a B. microti–infected mouse model. 17-DMAG showed the inhibitory effect in all of the species tested. The half maximum inhibition concentration (IC50) of 17-DMAG on B. bovis, B. bigemina, B. divergens, B. caballi, and T. equi was 77.6 ± 2.9, 62.4 ± 1.9, 183.8 ± 3.2, 88.5 ± 9.6, and 307.7 ± 7.2 nM, res...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites
Publication date: April 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 1Author(s): Roberto Sánchez-Sánchez, Ignacio Ferre, Michela Re, Patricia Vázquez, Luis Miguel Ferrer, Javier Blanco-Murcia, Javier Regidor-Cerrillo, Manuel Pizarro Díaz, Marta González-Huecas, Enrique Tabanera, Paula García-Lunar, Julio Benavides, Pablo Castaño, Andrew Hemphill, Matthew A. Hulverson, Grant R. Whitman, Kasey L. Rivas, Ryan Choi, Kayode K. Ojo, Lynn K. BarrettAbstractNeospora caninum is one of the main causes of abortion in cattle, and recent studies have highlighted its relevance as ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro
Publication date: Available online 4 June 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): H.M.P. Dilrukshi Herath, Hongjian Song, Sarah Preston, Abdul Jabbar, Tao Wang, Sean L. McGee, Andreas Hofmann, Jose Garcia-Bustos, Bill C.H. Chang, Anson V. Koehler, Yuxiu Liu, Qiaoqiao Ma, Pengxiang Zhang, Qiqi Zhao, Qingmin Wang, Robin B. GasserAbstractDue to widespread drug resistance in parasitic nematodes, there is a need develop new anthelmintics. Given the cost and time involved in developing a new drug, the repurposing of known chemicals can be a promising, alternative approach. In this ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Differentially expressed genes in response to amitraz treatment suggests a proposed model of resistance to amitraz in R. decoloratus ticks
Publication date: Available online 18 June 2018Source: International Journal for Parasitology: Drugs and Drug ResistanceAuthor(s): Samantha Baron, Roberto A. Barrero, Michael Black, Matthew I. Bellgard, Ellie van Dalen, Christine Maritz-OlivierAbstractThe widespread geographical distribution of Rhipicephalus decoloratus in southern Africa and its ability to transmit the pathogens causing redwater, gallsickness and spirochaetosis in cattle makes this hematophagous ectoparasite of economic importance. In South Africa, the most commonly used chemical acaricides to control tick populations are pyrethroids and amitraz. The curr...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota
This study highlights a strong relationship between tribendimidine and ivermectin administration and the gut microbiota and additional studies assessing the functional aspects as well as potential health-associated outcomes of these interactions are required.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Isothermal microcalorimetry – A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): M. Gysin, O. Braissant, K. Gillingwater, R. Brun, P. Mäser, T. WenzlerAbstractTrypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses. Two drugs are available, diminazene and isometamidium, yet successful treatment is jeopardized by drug resistant T. congolense. Isothermal microcalorimetry is a highly sensiti...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Cristina Ballesteros, James F. Geary, Charles D. Mackenzie, Timothy G. GearyAbstractLymphatic filariasis and onchocerciasis are neglected parasitic diseases which pose a threat to public health in tropical and sub-tropical regions. Strategies for control and elimination of these diseases by mass drug administration (MDA) campaigns are designed to reduce symptoms of onchocerciasis and transmission of both parasites to eventually eliminate the burden on public health. Drugs used for MDA are pred...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

High level efficacy of lufenuron against sea lice (Lepeophtheirus salmonis) linked to rapid impact on moulting processes
We describe multiple experiments to characterize the efficacy of lufenuron on eggs, larvae, and parasitic stages of L. salmonis, and provide the most comprehensive assessment of the physiological responses of a marine arthropod to a benzoylurea chemical.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites
In this study, we assessed the activity of 42 compounds demonstrated or predicted (using virtual screening of a pharmacophore model) to bind/inhibit eukaryotic BDPs for activity against Plasmodium falciparum malaria parasites. In silico docking studies indicated that all compounds are predicted to participate in a typical hydrogen bond interaction with the conserved asparagine (Asn1436) of the P. falciparum histone acetyltransferase (PfGCN5) bromodomain and a conserved water molecule. Only one compound (the dimethylisoxazole SGC-CBP30; a selective inhibitor of CREBBP (CBP) and EP300 bromodomains) is also predicted to have ...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Irene Fragiadaki, Anna Katogiritis, Theodora Calogeropoulou, Hans Brückner, Effie ScoulicaAbstractAnti-leishmanial treatment increasingly encounters therapeutic limitations due to drug toxicity and development of resistance. The effort for new therapeutic strategies led us to work on combinations of chemically different compounds that could yield enhanced leishmanicidal effect. Peptaibols are a special type of antimicrobial peptides that are able to form ion channels in cell membranes and pot...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48
Publication date: August 2018Source: International Journal for Parasitology: Drugs and Drug Resistance, Volume 8, Issue 2Author(s): Marta Martínez-García, Jean-Mathieu Bart, Jenny Campos-Salinas, Eva Valdivia, Manuel Martínez-Bueno, Elena González-Rey, Miguel Navarro, Mercedes Maqueda, Rubén Cebrián, José M. Pérez-VictoriaAbstractThe parasitic protozoan Trypanosoma brucei is the causative agent of human African trypanosomiasis (sleeping sickness) and nagana. Current drug therapies have limited efficacy, high toxicity and/or are continually hampered by the appearance of resistance. Antimicrobial peptides have recent...
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities
This study demonstrates that the anti-fecundity activity of 5-AzaC affects more than just DNA methylation in schistosome parasites. Further characterisation of these processes may reveal novel targets for schistosomiasis control.Graphical abstract (Source: International Journal for Parasitology: Drugs and Drug Resistance)
Source: International Journal for Parasitology: Drugs and Drug Resistance - July 5, 2018 Category: Parasitology Source Type: research