Resistance of Leishmania infantum to allopurinol is associated with chromosome and gene copy number variations including decrease in the S-adenosylmethionine synthetase (METK) gene copy number

In conclusion, this study identified genetic changes associated with L. infantum resistance to allopurinol and the reduction in METK copy number identified may serve as a marker for resistance in dogs, and reduced protein activity correlated with increased allopurinol resistance.Graphical abstractDistribution of relative quantity values (RQ) of gene LinJ.30.3560 from the 20 L. infantum clinical strains in relation to their allopurinol IC50.
Source: International Journal for Parasitology: Drugs and Drug Resistance - Category: Parasitology Source Type: research