Deoxyrhapontigenin, a Natural Stilbene Derivative Isolated From Rheum undulatum L. Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Human Breast Cancer Cells
The objective of the present study is to investigate the anticancer effect of a derivative of stilbene, deoxyrhapontigenin (DR) isolated from Rheum undulatum L. root extracts against the chemoresistant MCF-7/adr and its parental MCF-7 human breast cancer cells. The morphological images indicate that DR induces an extensive cytoplasmic vacuolation in breast cancer cells. Mechanistic investigations revealed that DR treatment causes endoplasmic reticulum (ER) dilation and upregulated the expression of ER stress markers GRP78, IRE1α, eIF2α, CHOP, JNK, and p38. Subsequently, we also identified that DR increases the ...
Source: Integrative Cancer Therapies - November 16, 2016 Category: Cancer & Oncology Authors: Venkatesan, T., Jeong, M.-J., Choi, Y.-W., Park, E.-J., El-Desouky, S. K., Kim, Y.-K. Tags: E-Only Section Source Type: research
Antitumor Effects of Systemic DNAse I and Proteases in an In Vivo Model
Conclusion. This study demonstrated that systemic treatment with DNAse I and a protease mix in rats decreases DNA and proteins from serum and that this treatment has antitumor effects. Our results support the hypothesis that circulating DNA could have a role in tumor progression, which can be offset by depleting it. Further studies are needed to prove this concept. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - November 16, 2016 Category: Cancer & Oncology Authors: Trejo-Becerril, C., Perez-Cardenas, E., Gutierrez-Diaz, B., De La Cruz-Sigüenza, D., Taja-Chayeb, L., Gonzalez-Ballesteros, M., Garcia-Lopez, P., Chanona, J., Duenas-Gonzalez, A. Tags: E-Only Section Source Type: research
Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells
In the current study, we investigated the chemopreventive activity of arabinoxylan rice bran, MGN-3/Biobran, against chemical induction of glandular stomach carcinogenesis in rats. Gastric cancer was induced by carcinogen methylnitronitrosoguanidine (MNNG), and rats received MNNG alone or MNNG plus Biobran (40 mg/kg body weight) for a total of 8 months. Averaged results from 2 separate readings showed that exposure to MNNG plus Biobran caused gastric dysplasia and cancer (adenocarcinoma) in 4.5/12 rats (9/24 readings, 37.5%), with 3.5/12 rats (7/24 readings, 29.2%) showing dysplasia and 1/12 rats (8.3%) developing adenocar...
Source: Integrative Cancer Therapies - November 16, 2016 Category: Cancer & Oncology Authors: Badr El-Din, N. K., Abdel Fattah, S. M., Pan, D., Tolentino, L., Ghoneum, M. Tags: E-Only Section Source Type: research
Immune Cell-Conditioned Media Suppress Prostate Cancer PC-3 Cell Growth Correlating With Decreased Proinflammatory/Anti-inflammatory Cytokine Ratios in the Media Using 5 Selected Crude Polysaccharides
Five different crude polysaccharides from guava seed (GSPS), bitter buckwheat (BBPS), common buckwheat (CBPS), red Formosa lambsquarters (RFLPS), and yellow Formosa lambsquarters (YFLPS) were isolated to treat human prostate cancer PC-3 cells via direct action or tumor immunotherapy. The splenocyte- and macrophage-conditioned media (SCM and MCM) were prepared using individual selected polysaccharides, and then SCM or MCM was further collected to treat PC-3 cells. The relationship between PC-3 cell growth and Th1/Th2 cytokines in SCM as well as proinflammatory/anti-inflammatory cytokine secretion profiles in MCM were deline...
Source: Integrative Cancer Therapies - November 16, 2016 Category: Cancer & Oncology Authors: Lin, H.-C., Lin, J.-Y. Tags: E-Only Section Source Type: research
Evaluation of Antiangiogenic Efficacy of Emilia sonchifolia (L.) DC on Tumor-Specific Neovessel Formation by Regulating MMPs, VEGF, and Proinflammatory Cytokines
Formation of new blood vessels from preexisting vasculature is an indispensable process in tumor initiation, invasion, and metastasis. Novel therapeutic approaches target endothelial cells involved in the process of angiogenesis, due to their genetic stability relative to the rapidly mutating drug-resistant cancer cells. In the present study, we investigated the effect of an active fraction from Emilia sonchifolia, belonging to the family Asteraceae, a plant well known for its anti-inflammatory and antitumor effects, on the inhibition of tumor-specific angiogenesis. Administration of the active fraction from E sonchifolia ...
Source: Integrative Cancer Therapies - November 16, 2016 Category: Cancer & Oncology Authors: Gilcy, G. K., Kuttan, G. Tags: E-Only Section Source Type: research
TPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer
This study suggests that phospholipid/TPGS mixed micelles might be a suitable drug delivery system for Icariside II to treat multidrug resistant breast cancer. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Song, J., Huang, H., Xia, Z., Wei, Y., Yao, N., Zhang, L., Yan, H., Jia, X., Zhang, Z. Tags: Articles Source Type: research
Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
Conclusion. BME functions as a natural AMPK activator in the inhibition of ovarian cancer cell growth and might be useful as a supplement to improve the efficacy of cisplatin-based chemotherapy in ovarian cancer. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Yung, M. M. H., Ross, F. A., Hardie, D. G., Leung, T. H. Y., Zhan, J., Ngan, H. Y. S., Chan, D. W. Tags: Articles Source Type: research
Herbal Compound Songyou Yin and Moderate Swimming Suppress Growth and Metastasis of Liver Cancer by Enhancing Immune Function
Conclusion. The combined application of SYY and MS exerted an enhanced effect on suppressing growth and metastasis of liver cancer by strengthening immunity. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Zhang, Q.-B., Meng, X.-T., Jia, Q.-A., Bu, Y., Ren, Z.-G., Zhang, B.-H., Tang, Z.-Y. Tags: Articles Source Type: research
Chemomodulatory Potential of Flaxseed Oil Against DMBA/Croton Oil-Induced Skin Carcinogenesis in Mice
The present study was conducted to evaluate the potential of flaxseed oil to prevent chemically induced skin cancer in mice. Cancer was induced on 2-stage skin carcinogenesis model by single topical application of 7,12 dimethylbenz [a]anthracene (DMBA), as, initiator, and two weeks later it was promoted by croton oil treatment thrice a week on the dorsal surface of mice for 16 weeks. Flaxseed oil (FSO; 100µL/animal/d) was orally administered 1 week before and 1 week after DMBA application (Peri-initiation stage). The animals of the FSO-administered group showed a significant reduction in tumor incidence (76.67%), cum...
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Sharma, J., Singh, R., Goyal, P. K. Tags: Articles Source Type: research
Jian Pi Li Qi Decoction Alleviated Postembolization Syndrome Following Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Randomized, Double-Blind, Placebo-Controlled Trial
Conclusion. JPLQ decoction may be an effective modality to relieve PES and protect liver function in patients with HCC after TACE. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Xu, L., Wang, S., Zhuang, L., Lin, J., Chen, H., Zhu, X., Bei, W., Zhao, Q., Wu, H., Meng, Z. Tags: Articles Source Type: research
Building an Integrative Outpatient Care Program for Breast Cancer Patients in Taiwan
Conclusions. Our results demonstrated that an integrative outpatient care program of conventional and Chinese medicine is feasible. Most patients were satisfied with this program and the quality of life was improved. It is important to conduct more research to build a model that integrates CAM with conventional medicine in Taiwan. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Lin, Y.-H., Shiu, J.-H., Chen, F.-P., Chiu, J.-H. Tags: Articles Source Type: research
Current Usage of Traditional Chinese Medicine in the Management of Breast Cancer: A Practitioners Perspective
Conclusion. The lack of an integrated medicine approach in relation to TCM makes it difficult to demonstrate the value of the contribution TCM can make to biomedicine in the field of breast care oncology. Effectiveness studies are needed that can accurately represent TCM in this field. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: McPherson, L., Cochrane, S., Zhu, X. Tags: Articles Source Type: research
Curcumin: A Natural Multitarget Treatment for Pancreatic Cancer
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Sahebkar, A. Tags: Commentary Source Type: research
Acupuncture for Dyspnea in Lung Cancer: Results of a Feasibility Trial
Conclusion. Among patients with LC, acupuncture was well tolerated and exhibited promising preliminary beneficial effects in the treatment of dyspnea, fatigue, and quality of life. Performing a trial in this population appears feasible. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Bauml, J., Haas, A., Simone, C. B., Li, S. Q., Cohen, R. B., Langer, C. J., Mao, J. J. Tags: Articles Source Type: research
Consumption of Whole Grains, Refined Cereals, and Legumes and Its Association With Colorectal Cancer Among Jordanians
Conclusion. This study provides additional indicators of the protective role of whole grains and suggests a direct association between consumption of refined grains and higher possibility for developing CRC. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 1, 2016 Category: Cancer & Oncology Authors: Tayyem, R. F., Bawadi, H. A., Shehadah, I., Agraib, L. M., Al-Awwad, N. J., Heath, D. D., Bani-Hani, K. E. Tags: Articles Source Type: research
