Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Gemcitabine Effects Against Pancreatic Cancer
Pancreatic cancer is one of the most lethal malignancies with very limited treatment option. In the effort of enhancing the effect of the conventional chemotherapeutic drug gemcitabine against pancreatic cancer, we investigated in vitro and in vivo the anticancer effect of a β-carboline-enriched extract from the plant Rauwolfia vomitoria (Rau), either alone or in combination with gemcitabine, in preclinical pancreatic cancer models. Rau induced apoptosis in pancreatic cancer cells in a concentration-dependent manner, and completely inhibited colony formation of PANC-1 cells in soft agar. The combination of Rau and gem...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Yu, J., Chen, Q. Tags: Articles Source Type: research
Efficacy and Safety of Moxibustion for Relieving Pain in Patients With Metastatic Cancer: A Pilot, Randomized, Single-Blind, Sham-Controlled Trial
Conclusion. We suggest that moxibustion could be a safe and potential modality for cancer-related pain in patients with metastatic cancer. With the limitation of small sample size, a larger and long-term follow-up study is necessary to determine more definitely the efficacy of moxibustion. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Lee, J., Yoon, S. W. Tags: Articles Source Type: research
The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study
Conclusions. Gargling with turmeric by head and neck cancer patients undergoing radiation therapy provided significant benefit by delaying and reducing the severity of mucositis. Turmeric is readily available, relatively inexpensive, and highly accepted making it useful in cancer treatment. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Rao, S., Dinkar, C., Vaishnav, L. K., Rao, P., Rai, M. P., Fayad, R., Baliga, M. S. Tags: Articles Source Type: research
Meta-Analysis of Randomized Controlled Trials of Acupuncture for Cancer-Related Fatigue
Conclusions. There were 4 sets of comparison for the effectiveness of acupuncture for CRF; statistical pooling of the reduction in CRF from baseline to follow-up showed in favor of acupuncture. However, 3 sets of comparison for the pooled estimates of effect sizes had no statistical significance. Although one set of comparison (acupuncture plus education interventions vs usual care) had statistically significant differences, it is unclear whether this pooled positive outcome is attributable to the effects of acupuncture or to the education intervention. In addition, the duration of follow-up in these included trials was up...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Zeng, Y., Luo, T., Finnegan-John, J., Cheng, A. S. K. Tags: Articles Source Type: research
Flax and Breast Cancer: A Systematic Review
Conclusions. Current evidence suggests that flax may be associated with decreased risk of breast cancer. Flax demonstrates antiproliferative effects in breast tissue of women at risk of breast cancer and may protect against primary breast cancer. Mortality risk may also be reduced among those living with breast cancer. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Flower, G., Fritz, H., Balneaves, L. G., Verma, S., Skidmore, B., Fernandes, R., Kennedy, D., Cooley, K., Wong, R., Sagar, S., Fergusson, D., Seely, D. Tags: Articles Source Type: research
In This Issue
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Block, K. I. Tags: Editorial Source Type: research
Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells
Furano-1,2-naphthoquinone (FNQ), a biologically active component of Avicennia marina, has been demonstrated to display anticancer activity. FNQ exerted cytotoxicity with the G2/M cell cycle arrest and apoptosis in Ca9-22 cells. FNQ-induced G2/M arrest was correlated with a marked decrease in the expression levels of cyclin A and cyclin B, and their activating partner cyclin-dependent kinases (CDK) 1 and 2 with concomitant induction of p27. FNQ-induced apoptosis was accompanied by Bax and Bad upregulation, and the downregulation of Bcl-2, Bcl-XL, Mcl-1, and X-linked inhibitor of apoptosis (XIAP), resulting in cytochrome C r...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Lin, K.-L., Chien, C.-M., Tseng, C.-H., Chen, Y.-L., Chang, L.-S., Lin, S.-R. Tags: E- Only Section Source Type: research
Ginkgo May Sensitize Ovarian Cancer Cells to Cisplatin: Antiproliferative and Apoptosis-Inducing Effects of Ginkgolide B on Ovarian Cancer Cells
This study suggests that GB can be proposed as an effective antiproliferative and apoptosis-inducing agent with interesting translational application in ovarian cancers, used in addition to conventional chemotherapy. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Jiang, W., Cong, Q., Wang, Y., Ye, B., Xu, C. Tags: E- Only Section Source Type: research
Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation
In this study, the cytotoxic mechanism of its extracts was investigated using methylene blue assay. The cytotoxic screening results revealed the ethyl acetate extract as the most potent extract by displaying prominent dose-dependent and time-dependent growth inhibitions in human liver carcinoma HepG2 cells with the lowest EC50 value of 9.38 ± 0.43 µg/mL after 72 hours of treatment. Acute exposure of the HepG2 cells to the ethyl acetate extract produced a significant regulation of caspase-3 with the peak expression at 8 hours of treatment (P < .05). DNA fragmentation indicated by DeadEnd Apoptosis Detection ...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Ooi, K. L., Tengku Muhammad, T. S., Lam, L. Y., Sulaiman, S. F. Tags: E- Only Section Source Type: research
Effect of Botanical Immunomodulators on Human CYP3A4 Inhibition: Implications for Concurrent Use as Adjuvants in Cancer Therapy
Conclusion. Our findings suggest that constituents of TCE extract especially protoberberine alkaloids have the potential to interact with cancer chemotherapy agents that are metabolized by CYP3A4 in vivo. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Patil, D., Gautam, M., Gairola, S., Jadhav, S., Patwardhan, B. Tags: Articles Source Type: research
Ganoderma lucidum Spore Induced CA72-4 Elevation in Gastrointestinal Cancer: A Five-Case Report
Ganoderma lucidum spore (GLS), an over-the-counter herbal supplement, is widely used by cancer patients in China. Although preclinical studies have shown it to be safe, complete safety data on GLS is still lacking. In this article, we report 5 cases of gastrointestinal cancer that were treated with GLS plus multiple strategies between 2010 and 2011. These patients presented with increased levels of the serum tumor marker CA72-4, one of the most valuable markers for monitoring therapeutic response in patients receiving gastrointestinal cancer treatment, after oral ingestion of GLS twice a day for 1 or 2 months. Interestingl...
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Yan, B., Meng, X., Shi, J., Qin, Z., Wei, P., Lao, L. Tags: Articles Source Type: research
A Novel Herbal Formula Induces Cell Cycle Arrest and Apoptosis in Association With Suppressing the PI3K/AKT Pathway in Human Lung Cancer A549 Cells
Conclusion. Ke formula inhibits tumor growth in an A549 xenograft mouse model with no obvious side effects. Moreover, Ke exhibits synergistic antitumor effects when combined with DDP. The mechanism of action of Ke is to induce cell cycle arrest and apoptosis by suppressing the PI3K/AKT pathway. Further research will be required to determine the mechanism of action behind the synergistic effect of Ke and DDP. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Xiong, F., Jiang, M., Huang, Z., Chen, M., Chen, K., Zhou, J., Yin, L., Tang, Y., Wang, M., Ye, L., Zhan, Z., Duan, J., Fu, H., Zhang, X. Tags: Articles Source Type: research
Decalepis hamiltonii Inhibits Tumor Progression and Metastasis by Regulating the Inflammatory Mediators and Nuclear Factor {kappa}B Subunits
Metastasis is an extremely complex process that is a major problem in the management of cancer. In the present study, we had evaluated the antimetastatic activity of Decalepis hamiltonii using B16F-10 melanoma-induced experimental lung metastasis in a C57BL/6 mice model. D hamiltonii treatment significantly (P < .01) inhibited lung tumor nodule formation and reduced the lung collagen hydroxyproline, hexosamine, and uronic acid levels. Similarly serum sialic acid and -glutamyl transpeptidase levels were also significantly inhibited after D hamiltonii treatment. The levels of proinflammatory cytokines such as tumor necros...
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Shathish, K., Guruvayoorappan, C. Tags: Articles Source Type: research
Acupuncture for Treatment of Uncontrolled Pain in Cancer Patients: A Pragmatic Pilot Study
Conclusions. Acupuncture was feasible, safe, and a helpful treatment adjunct for cancer patients experiencing uncontrolled pain in this study. Randomized placebo-controlled trials are needed to confirm these results. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Garcia, M. K., Driver, L., Haddad, R., Lee, R., Palmer, J. L., Wei, Q., Frenkel, M., Cohen, L. Tags: Articles Source Type: research
A Pilot Study of a Home-Based Motivational Exercise Program for African American Breast Cancer Survivors: Clinical and Quality-of-Life Outcomes
Conclusions. The intervention led to increased physical activity. As a result of increased levels of physical activity, improvements on several fitness/health parameters occurred. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - February 19, 2014 Category: Cancer & Oncology Authors: Spector, D., Deal, A. M., Amos, K. D., Yang, H., Battaglini, C. L. Tags: Articles Source Type: research
