The National Cancer Institute Best Case Series Program: A Summary of Cases of Cancer Patients Treated With Unconventional Therapies in India
Conclusion. The challenge for submitters rests in their ability to supply sufficient documentation for the NCI BCS Program. The NCI BCS Program represents a unique avenue for the rigorous evaluation of "best cases" to identify complementary and alternative medicine modalities that are promising for prospective preclinical evaluation or prospective research. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 27, 2013 Category: Cancer & Oncology Authors: Olaku, O., Zia, F., Santana, J. M., White, J. D. Tags: Articles Source Type: research
Integrating Dietary Supplements Into Cancer Care
Many studies confirm that a majority of patients undergoing cancer therapy use self-selected forms of complementary therapies, mainly dietary supplements. Unfortunately, patients often do not report their use of supplements to their providers. The failure of physicians to communicate effectively with patients on this use may result in a loss of trust within the therapeutic relationship and in the selection by patients of harmful, useless, or ineffective and costly nonconventional therapies when effective integrative interventions may exist. Poor communication may also lead to diminishment of patient autonomy and self-effic...
Source: Integrative Cancer Therapies - August 27, 2013 Category: Cancer & Oncology Authors: Frenkel, M., Abrams, D. I., Ladas, E. J., Deng, G., Hardy, M., Capodice, J. L., Winegardner, M. F., Gubili, J. K., Yeung, K. S., Kussmann, H., Block, K. I. Tags: Articles Source Type: research
In This Issue: Increasing Impact of Integrative Cancer Therapies
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 27, 2013 Category: Cancer & Oncology Authors: Block, K. I. Tags: Editorial Source Type: research
Human Breast Adenocarcinoma Cytotoxicity and Modulation of 7,12-Dimethylbenz[a]anthracene-Induced Mammary Carcinoma in Balb/c Mice by Acacia catechu (L.f.) Wild Heartwood
Conclusions. The present data strongly suggest that anticancer potentiality of (+)-catechin-rich AQCE may be attributable to its ability to positively modulate tumor markers as well as the antioxidant system that could decompose the peroxides and, thereby, offer a protection against lipid peroxidation and linked to the expression of transcription factors during DMBA-induced mammary carcinoma. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Monga, J., Chauhan, C. S., Sharma, M. Tags: Articles Source Type: research
An In Vitro and In Vivo Investigation of the Antimetastatic Effects of a Chinese Medicinal Decoction, Erxian Decoction, on Human Ovarian Cancer Models
Conclusions. This is the first study that illustrates the antimetastatic property of EXD on human ovarian cancer models. This decoction merits serious consideration for further delineation of its multiple pharmacological effects, especially on hormone-related cancers, and these would be valuable for future clinical applications of EXD as an alternative regime for cancers. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Chu, E. S. M., Sze, S. C. W., Cheung, H. P., Liu, Q., Ng, T. B., Tong, Y. Tags: Articles Source Type: research
Effects of a Physical Activity Behavior Change Intervention on Inflammation and Related Health Outcomes in Breast Cancer Survivors: Pilot Randomized Trial
Conclusions. Physical activity behavior change interventions in BCSs can achieve large effect size changes for several health outcomes. Although effect sizes for inflammatory markers were often small and not significant, changes were in the hypothesized direction for all except IL-6 and IL-10. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Rogers, L. Q., Fogleman, A., Trammell, R., Hopkins-Price, P., Vicari, S., Rao, K., Edson, B., Verhulst, S., Courneya, K. S., Hoelzer, K. Tags: Articles Source Type: research
Effect of Withania somnifera (Ashwagandha) on the Development of Chemotherapy-Induced Fatigue and Quality of Life in Breast Cancer Patients
Conclusions. Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life. However, further study with a larger sample size in a randomized trial is warranted to validate our findings. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Biswal, B. M., Sulaiman, S. A., Ismail, H. C., Zakaria, H., Musa, K. I. Tags: Articles Source Type: research
Multimodal Therapy Concept and Aerobic Training in Breast Cancer Patients With Chronic Cancer-Related Fatigue
Conclusion:
The multimodal therapy concept was feasible and improved cancer fatigue, sleep quality, autonomic and rest-/activity regulation in breast cancer patients. It may therefore constitute a valuable treatment option in addition to aerobic training for BC patients with CRF. A further study with larger sample size needs to be carried out to assess the efficacy of combined multimodal-aerobic therapy. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Kroz, M., Fink, M., Reif, M., Grobbecker, S., Zerm, R., Quetz, M., Fruhwirth, M., Brinkhaus, B., Bartsch, C., Girke, M., Gutenbrunner, C. Tags: Articles Source Type: research
Can a Multimodal Mind-Body Program Enhance the Treatment Effects of Physical Activity in Breast Cancer Survivors With Chronic Tumor-Associated Fatigue? A Randomized Controlled Trial
Conclusion. Since both interventions reduced fatigue symptoms and enhanced QoL to a similar extent, we observed no verifiable add-on effect of the MMMT regarding fatigue symptoms. Considering the higher costs with additional expenditure related to MMMT, home-based walking intervention is recommended. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Spahn, G., Choi, K.-E., Kennemann, C., Ludtke, R., Franken, U., Langhorst, J., Paul, A., Dobos, G. J. Tags: Articles Source Type: research
A Systematic Review of Complementary and Alternative Medicine Interventions for the Management of Cancer-Related Fatigue
Fatigue, experienced by patients during and following cancer treatment, is a significant clinical problem. It is a prevalent and distressing symptom yet pharmacological interventions are used little and confer limited benefit for patients. However, many cancer patients use some form of complementary and alternative medicine (CAM), and some evidence suggests it may relieve fatigue. A systematic review was conducted to appraise the effectiveness of CAM interventions in ameliorating cancer-related fatigue. Systematic searches of biomedical, nursing, and specialist CAM databases were conducted, including Medline, Embase, and A...
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Finnegan-John, J., Molassiotis, A., Richardson, A., Ream, E. Tags: Articles Source Type: research
In This Issue: Four Studies on Cancer-Related Fatigue
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - June 13, 2013 Category: Cancer & Oncology Authors: Block, K. I. Tags: Editorial Source Type: research
Quercetin Liposome Sensitizes Colon Carcinoma to Thermotherapy and Thermochemotherapy in Mice Models
This study was designed to investigate whether quercetin could enhance sensitivity to thermotherapy and thermochemotherapy. Soluble quercetin liposome was used in this study. The effects of quercetin were investigated in vitro and in mouse colon cancer models of subcutaneous tumor and peritoneal carcinomatosis. The results showed that quercetin liposome inhibited the upregulation of Hsp70 and enhanced apoptosis induced by hyperthermia and thermochemotherapy. Systemic administration of quercetin liposome can sensitize CT26 cells to thermotherapy and chemothermotherapy. This study suggests that quercetin liposome might be po...
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: He, B., Wang, X., Shi, H.-s., Xiao, W.-j., Zhang, J., Mu, B., Mao, Y.-q., Wang, W., Wang, Y.-s. Tags: Articles Source Type: research
Thymoquinone Efficiently Inhibits the Survival of EBV-Infected B Cells and Alters EBV Gene Expression
In this study, the modulator activity of the potent herbal extract drug thymoquinone on EBV was assessed in vitro. Thymoquinone was tested for cytotoxicity on human cells of lymphoblastoid cells, Raji Burkitt’s lymphoma, DG-75 Burkitt’s lymphoma, peripheral blood mononuclear cells, and periodontal ligament fibroblast. Apoptosis induction was analyzed via TUNEL assay and activity studies of caspase-3. The effect of thymoquinone on EBV gene expression was determined using real-time polymerase chain reaction. We report here, for the first time, a promising selective inhibitory affect of thymoquinone on EBV-infecte...
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: Zihlif, M. A., Mahmoud, I. S., Ghanim, M. T., Zreikat, M. S., Alrabadi, N., Imraish, A., Odeh, F., Abbas, M. A., Ismail, S. I. Tags: Articles Source Type: research
Fermentation Product of Soybean, Black Bean, and Green Bean Mixture Induces Apoptosis in a Wide Variety of Cancer Cells
In this study, the anticancer activities of a fermentation product of soybean, black bean, and green bean mixture (BN999) were investigated. We found that BN999 inhibited the growth of human breast cancer AU565 cells and prostate adenocarcinoma PC-3 cells but not that of normal human cells. BN999 induced apoptosis in various human cancer cells but not in normal human cells. BN999 treatment of AU565 cancer cells resulted in activation of calpain and caspase-8, -9, and -3, suggesting that BN999 induces apoptosis via receptor-, mitochondria-, and endoplasmic reticulum–mediated pathways. Finally, we showed that BN999 inh...
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: Chia, J.-S., Du, J.-L., Wu, M.-S., Hsu, W.-B., Chiang, C.-P., Sun, A., Lu, J. J.-Y., Wang, W.-B. Tags: Articles Source Type: research
Sphaeranthus indicus Induces Apoptosis Through Mitochondrial-Dependent Pathway in HL-60 Cells and Exerts Cytotoxic Potential on Several Human Cancer Cell Lines
Discussion. All the above parameters revealed that SIP induced apoptosis through the mitochondrial-dependent pathway in HL-60 cells. The criterion for anticancer activity in cytotoxicity assay was ≥70% growth inhibition at 100 µg/mL against at least 4 cell lines. As G lucidum and U dioica did not exhibit appreciable inhibitory activity against human cancer cell lines (less than 50%), they were not included in the study thereafter. The results established that SIP has apoptosis-inducing effect against HL-60 cells in vitro and is a promising candidate for further anticancer study. β-Sitosterol and 7-hydroxyfrul...
Source: Integrative Cancer Therapies - April 18, 2013 Category: Cancer & Oncology Authors: Nahata, A., Saxena, A., Suri, N., Saxena, A. K., Dixit, V. K. Tags: Articles Source Type: research
