A Pilot Study of Acupuncture in Treating Bortezomib-Induced Peripheral Neuropathy in Patients With Multiple Myeloma
Conclusions. Acupuncture is safe, feasible and produces subjective improvements in patients’ symptoms. A follow-up randomized controlled trial is warranted. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 11, 2014 Category: Cancer & Oncology Authors: Bao, T., Goloubeva, O., Pelser, C., Porter, N., Primrose, J., Hester, L., Sadowska, M., Lapidus, R., Medeiros, M., Lao, L., Dorsey, S. G., Badros, A. Z. Tags: Articles Source Type: research
Beyond Androgen Deprivation: Ancillary Integrative Strategies for Targeting the Androgen Receptor Addiction of Prostate Cancer
The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis—often reflecting increased NF-B activation; upregulation of signaling pathways that promote AR activity in the absence of androgens; and by emergence of AR mutations or splice variants lacking the ligand-binding domain, which render the AR constitutively active. Drugs targeting the N-terminal transactivating domain of the AR, some of which are now...
Source: Integrative Cancer Therapies - August 11, 2014 Category: Cancer & Oncology Authors: McCarty, M. F., Hejazi, J., Rastmanesh, R. Tags: Articles Source Type: research
Acupuncture in the Treatment of Cancer-Related Psychological Symptoms
In conclusion, results are encouraging for the development of randomized trials to directly evaluate the therapeutic impact of acupuncture in cancer-related psychological symptoms, including depression, anxiety, sleep disturbance, and quality of life, but attention to acupuncture methodological specific challenges in the development of high-quality research is necessary. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - August 11, 2014 Category: Cancer & Oncology Authors: Haddad, N. E., Palesh, O. Tags: Articles Source Type: research
Assessment of Augmented Immune Surveillance and Tumor Cell Death by Cytoplasmic Stabilization of p53 as a Chemopreventive Strategy of 3 Promising Medicinal Herbs in Murine 2-Stage Skin Carcinogenesis
This study reports the inhibition of proliferation by augmenting immune surveillance, silencing acute inflammation, and inducing p53-mediated apoptosis of skin cancer by 3 promising medicinal extracts. We used the well-characterized model for experimental skin carcinogenesis in mice for 32 weeks to study the chemopreventive effect of the methanolic extracts of Trigonella foenumgraecum, Eclipta alba, and Calendula officinalis. All 3 extracts reduced the number, incidence, and multiplicity of tumors, which was confirmed by the pathologic studies that showed regressed tumors. There was a significant reduction in the PCNA+ nuc...
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Ali, F., Khan, R., Khan, A. Q., Lateef, M. A., Maqbool, T., Sultana, S. Tags: Articles Source Type: research
Beneficial Effects of Pranic Meditation on the Mental Health and Quality of Life of Breast Cancer Survivors
Conclusions. The results of this pilot study showed that breast cancer survivors presented significant benefits related to their mental health and quality of life scores after a short period of practice of pranic meditation, consisting of simple and easy-to-learn exercises. However, because of the limitations of the study, further research is required using a more rigorous experimental design to ascertain whether pranic meditation may be an acceptable adjunct therapy for cancer patients. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Castellar, J. I., Fernandes, C. A., Tosta, C. E. Tags: Articles Source Type: research
Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma: A Retrospective Analysis
In conclusion, the application is feasible and safe, and its efficacy should be evaluated in a randomized controlled trial. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Schad, F., Atxner, J., Buchwald, D., Happe, A., Popp, S., Kroz, M., Matthes, H. Tags: Articles Source Type: research
Cancer Prevention and Therapy: Integrating Traditional Korean Medicine Into Modern Cancer Care
In spite of billions of dollars spent on cancer research each year, overall cancer incidence and cancer survival has not changed significantly in the last half century. Instead, the recent projection from the World Health Organization suggests that global cancer incidence and death is expected to double within the next decade. This requires an "out of the box" thinking approach. While traditional medicine used for thousands of years is safe and affordable, its efficacy and mechanism of action are not fully reported. Demonstrating that traditional medicine is efficacious and how it works can provide a "bed to bench" and "be...
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Yoon, S. W., Jeong, J. S., Kim, J. H., Aggarwal, B. B. Tags: Articles Source Type: research
Psychosocial and Behavioral Interventions and Cancer Patient Survival Again: Hints of an Adjusted Meta-Analysis
Conclusion. PBIs with adequate intervention doses prolong survival at least for some cancer patients in the first 2 years after intervention, although longer term effects need to be determined via more studies. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Xia, Y., Tong, G., Feng, R., Chai, J., Cheng, J., Wang, D. Tags: Articles Source Type: research
Intravenous Vitamin C and Cancer: A Systematic Review
Conclusion. There is limited high-quality clinical evidence on the safety and effectiveness of IVC. The existing evidence is preliminary and cannot be considered conclusive but is suggestive of a good safety profile and potentially important antitumor activity; however, more rigorous evidence is needed to conclusively demonstrate these effects. IVC may improve the quality of life and symptom severity of patients with cancer, and several cases of cancer remission have been reported. Well-designed, controlled studies of IVC therapy are needed. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Fritz, H., Flower, G., Weeks, L., Cooley, K., Callachan, M., McGowan, J., Skidmore, B., Kirchner, L., Seely, D. Tags: Articles Source Type: research
In This Issue
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - July 8, 2014 Category: Cancer & Oncology Authors: Block, K. I. Tags: Editorial Source Type: research
E- Only Section
(Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Tags: E- Only Section Source Type: research
Rubus idaeus L Inhibits Invasion Potential of Human A549 Lung Cancer Cells by Suppression Epithelial-to-Mesenchymal Transition and Akt Pathway In Vitro and Reduces Tumor Growth In Vivo
The metastasis of lung cancer is the most prevalent cause of patient death. Various treatment strategies have targeted the prevention of the occurrence of metastasis. The epithelial–mesenchymal transition (EMT) in lung cancer cells is considered a prerequisite to acquire the invasive/migratory phenotype and to subsequently achieve metastasis. However, the effects of Rubus idaeus on cancer invasion and the EMT of the human lung carcinoma remain unclear. In this article, we test the hypothesis that R idaeus ethyl acetate (RIAE) possesses an antimetastatic effect and reverses the EMT potential of human lung A549 cells. ...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Chu, S.-C., Hsieh, Y.-S., Hsu, L.-S., Chen, K.-S., Chiang, C.-C., Chen, P.-N. Tags: Articles Source Type: research
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NF{kappa}B Signaling
Pao extract, derived from bark of Amazonian tree Pao Pereira, is commonly used in South American medicine. A recent study showed that Pao extract repressed androgen-dependent LNCaP prostate cancer cell growth. We hypothesize that Pao extract asserts its anticancer effects on metastatic castration-resistant prostate cancer (CRPC) cells. Pao extract suppressed CRPC PC3 cell growth in a dose- and time-dependent manner, through induction of apoptosis and cell cycle arrest. Pao extract treatment induced cell cycle inhibitors, p21 and p27, and repressed PCNA, Cyclin A and Cyclin D1. Furthermore, Pao extract also induced the upre...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Chang, C., Zhao, W., Xie, B., Deng, Y., Han, T., Cui, Y., Dai, Y., Zhang, Z., Gao, J., Guo, H., Yan, J. Tags: Articles Source Type: research
Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways
The pathogenic mechanisms underlying cancer development are complex and heterogeneous, involving multiple cellular signaling transduction pathways that usually function redundantly. In addition, crosstalk between these pathways generates a complicated and robust signaling network that is regulated by compensatory mechanisms. Given the complexity of cancer pathogenesis and progression, many of the currently used antitumor agents, which typically target a single intracellular pathway, might not always be effective on complex tumor systems. Moreover, long-term use of these agents often generates drug resistance and toxicity a...
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Lin, J., Chen, Y., Cai, Q., Wei, L., Zhan, Y., Shen, A., Sferra, T. J., Peng, J. Tags: Articles Source Type: research
In Vitro and In Vivo Effects of Jia-Wei-Xiao-Yao-San in Human Breast Cancer MCF-7 Cells Treated With Tamoxifen
Conclusion. Based on in vitro studies and in vivo functional studies, there is no obvious interaction between JWXYS and Tam. However, the presence of interference at the molecular level in relation to LC3-II expression provides important information and may affect treatment strategies when physicians have patients with estrogen receptor-α(+) or progesterone receptor(+) breast cancers. (Source: Integrative Cancer Therapies)
Source: Integrative Cancer Therapies - May 14, 2014 Category: Cancer & Oncology Authors: Chen, J.-L., Chang, C.-J., Wang, J.-Y., Wen, C.-S., Tseng, L.-M., Chang, W.-C., Noomhorm, N., Liu, H.-J., Chen, W.-S., Chiu, J.-H., Shyr, Y.-M. Tags: Articles Source Type: research
