Metastatic gestational choriocarcinoma in lung incidentally found by hemoptysis and confirmed by DNA genotyping, highly suggesting the index antecedent pregnancy of a girl
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Shogo Kasuda, Koichi Suzuki, Yoshitane TsukamotoAbstractWe experienced a 46-year-old Japanese female with metastatic choriocarcinoma in lung found by hemoptysis. The Pathology findings of the surgical lung specimen showed multiple foci of peripheral clustering of trimorphic malignant trophoblasts with central hemorrhagic necrosis. Tumor cells were mostly immunoreactive for human chorionic gonadotropin (hCG). The pathological diagnosis of metastatic choriocarcinoma in lung was made. Rather...
Source: Human Pathology: Case Reports - November 2, 2019 Category: Pathology Source Type: research
Milk of calcium renal cyst and Liesegang structures
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Prashant Bavi, Jagdish Butany, Korosh Khalili, Runjan ChettyAbstractLiesegang rings are rare and very few cases reported in literature in association with malignancy. Although they have no biologic or clinical significance, unique morphology and unfamiliarity with these structures are often confused with malignancy, lithiasis and parasitic infestation. We herein report a case of milk of calcium renal cyst with Liesegang structures in an autopsy done on a pancreatic cancer patient who received neoadjuvant chemotherapy and was enrolled ...
Source: Human Pathology: Case Reports - October 25, 2019 Category: Pathology Source Type: research
Rapid progression of a low-grade follicular lymphoma with foci of high proliferation index and BCL6 rearrangement into a diffuse large B-cell lymphoma: A case report and review of the literature
We present a case study of a 74-year-old male who presented with right side flank pain and inguinal lymphadenopathy. The patient was diagnosed with low-grade follicular B-cell lymphoma with a low proliferative index (LGFL-LPI) and focal high proliferation index. Approximately 6 months later, the patient was diagnosed with LGFL-HPI with evidence of transformation into DLBCL of activated B-cell immunophenotype within the same lymph node. Separate fluorescence in situ hybridization (FISH) studies performed on the initial biopsy, the low grade component of the subsequent sample, and the transformed component of the subsequen...
Source: Human Pathology: Case Reports - October 20, 2019 Category: Pathology Source Type: research
Rare synchronous presentation and development of retroperitoneal dedifferentiated liposarcoma and rectal adenocarcinoma
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Cyrus Parsa, Robert Orlando, Krishna Narayanan, Umakant M. Khetan, Jin Guo, Ravin RupaniAbstractMultiple primary malignancies may occur as synchronous or meta-synchronous tumors in 2–17% of patients. Most multiple primary cancers occur in different locations of the same organ or in other organs such as lung, kidney, prostate, and bone. Occurrence of synchronous colorectal adenocarcinoma with liposarcoma, is exceptionally rare. A 79-year-old male presented with significant weight loss of 2–3 weeks duration following a transurethr...
Source: Human Pathology: Case Reports - October 11, 2019 Category: Pathology Source Type: research
Post-partum cutaneous manifestation of antiphospholipid syndrome
We describe a female patient that postpartum developed diffuse and rapidly progressing retiform purpura to highlight this atypical presentation noted after delivery. The diagnosis is complicated by the presence of vasculitis with fibrin thrombi in the skin biopsy in the absence of systemic vasculitis. This is of interest because vasculitis is a rare manifestation in antiphospholipid syndrome alone. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - October 11, 2019 Category: Pathology Source Type: research
Hypoplastic kidney with hyperplastic mesonephric remnants as a cause of unilateral non-functioning kidney in an adult male
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Diping Wang, Loren P. Herrera-Hernandez, Mariam P. Alexander (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - September 18, 2019 Category: Pathology Source Type: research
Membranoproliferative glomerulonephritis following tubulointerstitial nephritis is a late manifestation of IgG4-related kidney disease: A distinctive case
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Joichi Usui, Steven P. Salvatore, Mourhege Alsaloum, Alla Goldberg, Sheng Kuo, Surya V. SeshanAbstractIgG4-related kidney disease (IgG4RKD) generally presents as an active and chronic fibrosing tubulointerstitial nephritis. Recent reports have described glomerular lesions, typically with IgG4 containing subepithelial/membranous deposits as part of IgG4RKD. Herein, we report a case of IgG4-related membranoproliferative glomerulonephritis and associated tubulointerstitial nephritis in the clinical setting of IgG4-related autoimmune dise...
Source: Human Pathology: Case Reports - September 14, 2019 Category: Pathology Source Type: research
Hepatoid adenocarcinoma of distal ileum without inflammatory bowel disease; A rare case
We report herein a case of hepatoid adenocarcinoma without inflammatory bowel disease in the distal ileum. A 72-old Japanese female had an ileal tumor with peritoneal dissemination. Partial resection of ileum was performed. The cut surface of the tumor showed a pale-tan-colored solid tumor. Histologically, the tumor consisted trabecular or pseudoglandular proliferation of large polygonal cells, and resembled hepatocellular carcinoma. Thus, metastatic hepatocellular carcinoma was considered with increased serum AFP and PIVKA-II. However, image analysis failed to detect mass lesion in the liver. Hepatoid adenocarcinoma was m...
Source: Human Pathology: Case Reports - September 11, 2019 Category: Pathology Source Type: research
Primary gastric choriocarcinoma with multiple metastases – A case report and literature review of carcinogenesis
We reported a case of primary gastric choriocarcinoma in a 47-year-old female who presented with chronic gastric ulcer and upper gastrointestinal bleeding and severe anemia. Endoscopy showed an ulcerated mass in the gastric fundus that was biopsied and consistent with a choriocarcinoma by histomorphology and immunohistochemistry studies. Subsequent computed tomography (CT) scans revealed multiple brain lesions. The largest frontal lobe hemorrhagic lesion was resected and histology revealed metastatic choriocarcinoma. Two months prior to her presentation, the patient underwent right lower lobectomy of the lung and was diagn...
Source: Human Pathology: Case Reports - September 10, 2019 Category: Pathology Source Type: research
Combination of both primary pure squamous cell carcinoma (SCC) and conventional invasive lobular carcinoma (ILC) in the same breast; A rare case report and review of the literature
ConclusionPrimary pure SCC of the breast is a rare malignancy which has a rapid rate of growth and a poor prognosis, moreover, ILC has high metastatic rate. Due to rarity of such condition and uncertain treatment modality it should be kept in mind its presence to allow choosing adequate therapy. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - September 10, 2019 Category: Pathology Source Type: research
Two cases of poorly differentiated synovial sarcoma arising from the chest wall - One case of Ewing sarcoma-like small cell type with death 4 years after the first presentation and one case of high-grade spindle cell type receiving postoperative adjuvant chemotherapy
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital. A tentative pathological diagnosis was mesothelioma with small cell features. After several courses of chemotherapy consisting...
Source: Human Pathology: Case Reports - August 23, 2019 Category: Pathology Source Type: research
Pituitary mammosomatotroph tumor with folliculo-stellate and mucin cells in a child with McCune Albright syndrome
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Sadeem Al-Subaie, Mussa H. AlMalki, Maqsood Ahmed, Sadeq Al-DandanAbstractA pituitary tumor is a common manifestation of the endocrinopathies criterion in McCune Albright syndrome. Herein, we report a 12-year-old male with McCune Albright syndrome, who presented with dysmorphic features and tall stature, then, underwent a trans-sphenoidal resection of suprasellar lesion that revealed a pituitary mammosomatotroph tumor with a unique finding of folliculo-stellate and mucin cells. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - August 23, 2019 Category: Pathology Source Type: research
Food protein-induced enterocolitis syndrome, an uncommonly encountered pathologic entity
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): C.B. Webb, D.L. Zwick (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - August 9, 2019 Category: Pathology Source Type: research
Colonic malakoplakia in a liver transplant recipient: A case report
We report the case of a 55-year-old male patient who had an orthotropic liver transplant 2 years before presentation and had been taking a combination of tacrolimus and prednisolone. He reported chronic watery diarrhea for the previous 6 months with no history of infection. His colonoscopy showed diffuse multiple mucosal nodules and ulcers appearing in the rectum and throughout the colon. A colonic biopsy revealed infiltration of the lamina propria by chronic inflammatory cells and sheets of histiocytes with the inclusion of Michaelis-Gutmann bodies. Pathological findings were consistent with malakoplakia. This is the ...
Source: Human Pathology: Case Reports - July 25, 2019 Category: Pathology Source Type: research
Pseudochylothorax: An underdiagnosed entity
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Richa Pawar, Sucheta, Renuka Verma, Sant Prakash Kataria (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - July 13, 2019 Category: Pathology Source Type: research
