Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Atif Saleem, Rohan Joshi, Li Lei, Lhara Lezama, Shyam S. Raghavan, Nastaran Neishaboori, Mohana Roy, Joe Schroers-Martin, Gregory W. Charville, Christian Kunder, Brent Tan, Beth A. Martin, Yasodha Natkunam (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 27, 2020 Category: Pathology Source Type: research
Microscopic precursor lesions of uterine lymphangioleiomyomatosis associated with incidental nodal lymphangioleiomyomatosis: A case report and discussion of pathogenesis
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Charles M. LombardAbstractA 47 yo woman underwent resection of an endometrial adenocarcinoma with pelvic lymph node biopsies. She was found to have incidental nodal lymphangioleiomyomatosis (LAM). Subsequent clinical and radiographic evaluation showed no evidence of manifestations of tuberous sclerosis or pulmonary LAM. Examination of the uterus revealed small microscopic foci of myometrial precursor LAM lesions. These lesions were detected only by immunohistochemical stains for cathepsin K and HMB-45. It is proposed that the precursor c...
Source: Human Pathology: Case Reports - January 25, 2020 Category: Pathology Source Type: research
Giant posterior fossa tuberculoma in immunocompetent adults
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Sofiene Bouali, Kamel Bahri, Alia Zehani, Khalil Ghedira, Khansa Abderrahmen, Jalel KallelAbstractIntracranial tuberculoma mostly occurs in supratentorial location in adult patients and there are isolated cases with Infratentorial tuberculoma reported in the literature in the last 10 years. A 49-year-old man presented with progressive staggering gait and headache for 3 months and was diagnosed with a giant cerebullar tuberculoma. Although rare, our case demonstrates that tuberculoma should be considered in the differential diagnosis ...
Source: Human Pathology: Case Reports - January 16, 2020 Category: Pathology Source Type: research
Mucosal Schwann Cell Hamartoma in sigmoid colon – A rare case report and review of literature
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Xiuyan Feng, Hongzhi Xu, Nestor Dela CruzAbstractMucosal Schwann Cell Hamartoma (MSCH) of the gastrointestinal (GI) tract is an incidental finding by screening colonoscopy, rarely reported in the English literature since first described in 2009. We diagnosed a case of sigmoid colon MSCH in a 60-year-old female without a family history or medical history of Neurofibromatosis Type 1 (NF1, von Recklinghausen’s disease), neuronal lesion, MEN2, or other syndromes. The endoscopic exam revealed a 4 mm sessile polyp with no erosion or ulcerat...
Source: Human Pathology: Case Reports - January 12, 2020 Category: Pathology Source Type: research
A rare case of ceruminous Syringocystadenoma papilliferum arising from the bony external auditory canal of an elderly patient
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Faye Victoria C. Casimero, Ann Margaret V. ChangAbstractSyringocystadenoma papilliferum (SCAP) is an exceptionally rare benign adnexal neoplasm arising from the dermal ceruminous glands in the external auditory canal. Due to its lack of distinct clinical and radiologic features, definite diagnosis primarily relies on histopathologic examination after incisional or excisional biopsy. Only a handful of cases have been documented thus far. Herein, we report a case of SCAP in this unusual location. Existing literature regarding its clinical,...
Source: Human Pathology: Case Reports - December 20, 2019 Category: Pathology Source Type: research
A rare case of a 65 year old female with a mesenteric paraganglioma
We report a rare case of a mesenteric PGL in a 65-year-old asymptomatic female. She was treated by surgical resection of the small bowel mass and corresponding mesentery. Twelve prior cases of mesenteric paragangliomas exist in the literature. We report our findings and brief review of the current literature to date. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - December 19, 2019 Category: Pathology Source Type: research
A case of Ewing-like sarcoma showing trilaminar differentiation after treatment
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Mia C. Weiss, Marta Batus, Rahul B. Jadhav, Manuel Utset, Cristina O'Donoghue, Ira MillerAbstractHere we present a case of a 56 year old male with an Ewing-like bilateral retroperitoneal sarcoma with evidence of a EWSR1-POU5F1 fusion gene. Biopsy showed a high grade round cell sarcoma expressing strong membranous CD99 antigen. The tumor shrank considerably after extensive neoadjuvant chemo-radiation therapy. The resected specimens showed complete regression of the malignant component, with the residual tumor resembling ganglioglioma as...
Source: Human Pathology: Case Reports - December 11, 2019 Category: Pathology Source Type: research
Angiomyomatous hamartoma in the inguinal lymph node: A case report and literature review
We present a case of a 57-year-old white female with a left upper thigh mass located at the previous surgical site of the resection of a 15 cm, 505-glipoma 10 years ago. Magnetic resonance imaging showed a 1.7 × 3.1 × 2.9 cm soft tissue mass within the subcutaneous adipose tissues of her left upper thigh at the site of previous lipoma resection. No muscle or bone invasion was identified. The clinical impression was lipoma versus liposarcoma. The mass was surgically removed, and gross examination showed a tan-pink, well-demarcated soft mass with scalloped edges noted within the yellowish adipose tissue. The histolo...
Source: Human Pathology: Case Reports - December 11, 2019 Category: Pathology Source Type: research
Case report: Fifteen-year history of deep benign fibrous histiocytoma of the thigh with review of the literature
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Abrar J. Filfilan, Rana Ajabnoor, Ghader G Jamjoum, Nora H. Trabulsi, Mohammed O. NassifAbstractDeep benign fibrous histiocytoma (DBFH) is a rare mesenchymal tumor compared with cutaneous fibrous histiocytoma. As the diagnosis of DBFH may be clinically difficult, the presence of DBFH is usually confirmed after its excision. In this case study, we report a case of a 31-year-old man who lived with a painless mass in his right thigh for 15 years. After its examination by preoperative ultrasound and magnetic resonance imaging, the tumor...
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
A rare case of blue nevus in the rectum
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shroque Zaher, Nada SedeeqAbstractA 54 year old female of Sudanese origin with a history of hypothyroidism and hyperlipidemia presented to the gastroenterology department complaining of chronic abdominal pain, nausea and heartburn. Colonoscopy revealed an incidental 5 mm pigmented lesion just above the dentate line, which, following microscopy, was diagnosed as a blue nevus. To date, there are only 3 cases reported in the literature of this rare entity. Our case represents the fourth such case. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
Mucinous cystic neoplasm of the pancreas with type-1 autoimmune pancreatitis-like lesion
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Kevin Gowing, David F. Schaeffer, Hui-Min YangAbstractMucinous cystic neoplasm (MCN) is characterized by mucinous epithelial lining and subepithelial ovarian-like stroma and is a precursor to invasive carcinoma. Type 1 autoimmune pancreatitis (AIP), on the other hand, is a form of IgG4-related disease (IgG4-RD) and can present as a pancreatic mass. There is no known causal relationship between these two entities in the current literature. Here, we report a case of a middle-aged female patient who was found to have an enlarging pancrea...
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
Breast implant-associated anaplastic large cell lymphoma in the post-mastectomy setting: Clinical and therapeutic implications
We report a case of breast implant-associated anaplastic large cell lymphoma in a 70-year old woman, who 21 years previously had undergone bilateral breast augmentation with textured silicone implants. Eleven years later, she had bilateral implant removal with possible implant leak and presence of ‘atypical cells’ in the seroma. She then opted for prophylactic bilateral mastectomy in view of her strong family history of breast cancer and underwent reconstruction with subcutaneous gel implants. Eight months later, the patient noted right breast swelling and peri-implant effusion. The cytology was suspicious for lympho...
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
A case report of a misdiagnosed cesarean scar pregnancy in a hemodynamically compromised patient
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): A.J. Rivera-Rodríguez, O. Jiménez-Zarazúa, L.A. Castaldi-Bermúdez, L.N. Vélez-Ramírez, O. Camacho Coronel-Ciocca, M.A. Romero-Frances, A.M. Becerra-Baeza, JD. MondragónAbstractDifferential diagnosis between a cesarean scar pregnancy and a cervical pregnancy is difficult. Prompt and accurate diagnosis of an ectopic pregnancy is essential, thus localization of the implanted gestational sac and associated comorbidities are necessary to efficiently provide management. A case of a 30-year-old woman with three previous cesarean deliv...
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
Sarcomatoid malignant peritoneal mesothelioma: A rare case of sarcomatoid component with monosomy 9 appeared in ascites fluid
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Yuri Noda, Yuko Nakanishi, Kumi Masuda, Masaru YamasakiAbstractSarcomatoid mesothelioma (SM) is the rarest subtype of malignant mesothelioma (MM) with the poorest prognosis. Due to its aggressive nature, early diagnosis and treatment are required for SM, resulting in they significantly improve patient survival. Until now, effusion cytology using ancillary techniques has aided in the early diagnosis of MM, and the cytological findings of the epithelioid component of MM have been well described. However, there has been no detailed cytom...
Source: Human Pathology: Case Reports - November 26, 2019 Category: Pathology Source Type: research
Don’t judge a book by its cover – A CD4 negative variant of blastic plasmacytoid dendritic cell neoplasm (BPDCN)
Publication date: March 2020Source: Human Pathology: Case Reports, Volume 19Author(s): Mohammad S. Khan, Michael S. Lewis (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - November 22, 2019 Category: Pathology Source Type: research
