The diagnostic value of detection of high-risk HPV in differentiating primary bladder cancer versus uterine cervical cancer involving bladder - A case report
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Haiying Zhan, Elizabeth Korangy, Ying HuangAbstractUterine cervical cancer can invade the urinary bladder at an advanced stage. Distinguishing between primary urothelial carcinoma and secondary carcinoma involving the bladder is extremely important because these two clinical settings have completely different management and prognosis. It can be very challenging for pathologists to determine the tumor origin, since the carcinomas in bladder and cervix have overlapping histological features and immunohistochemical profiles. Here we rep...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
Monophasic epithelial synovial sarcoma initially diagnosed as metastatic adenocarcinoma of unknown primary
We report a case of monophasic epithelial synovial sarcoma, which was initially diagnosed as metastatic adenocarcinoma. A 45-year-old woman presented with a tender pelvic mass, whose morphology was consistent with a glandular neoplasm. The mass was misdiagnosed as metastatic adenocarcinoma of unknown primary, and was treated as such. The tumor recurred 12 years later; it showed biphasic morphology including glandular and spindle sarcomatoid components. TLE1 immunoreactivity of the second tumor supported diagnosis of biphasic synovial sarcoma. The original lesion was reexamined and revealed very focal minor spindle tumor ...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
Primary intestinal NK-cell lymphoma, EBV-negative: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Matthew Koo, Olga Olevsky, Kathleen Ruchalski, Sophie SongAbstractPrimary intestinal NK-cell lymphoma (PINKL) is a rare entity with an overall poor prognosis. It is frequently EBV-positive and is characteristically negative for a T-cell gene rearrangement. Some parameters that may confer a relatively good prognosis include unifocality, the absence of intestinal perforation, and possibly EBV negativity. While exceedingly rare case reports of EBV-negative PINKL are available in the literature, the NK-cell phenotype of these lymphomas i...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
Extranodal Rosai-Dorfman disease of the kidney: A case report
We present a case of extranodal RDD of the kidney. Imaging revealed a nodular lesion in the right renal pelvis, with accompanying pelvic dilation and parenchymal atrophy, reminiscent of immunoglobulin G4 (IgG4)-related disease. With the clinical diagnosis of suspected renal pelvic cancer, laparoscopic right nephrectomy was performed. Macroscopic findings showed a mass with a white-tan cut surface. Histological examination revealed histiocytes with emperipolesis and patchy infiltration of plasma cells, lymphocytes and foamy macrophages in a fibrocollagenous stroma. Immunohistochemically, the histiocytes were positive for S1...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature
ConclusionsMMB is extremely rare entity which showed be suspected during differential diagnosis of any malignant spindle cell tumor of the breast. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
Whole transcriptome analysis identifies upregulated genes and pathways in ductal carcinoma in situ mimicking usual ductal hyperplasia
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Jennifer Zeng, Jonathan Serrano, Matija Snuderl, Farbod Darvishian (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 20, 2019 Category: Pathology Source Type: research
EBV positive extranodal NK/T cell lymphoma presenting as intestinal lymphoma- A diagnostic challenge
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Nitya Prabhakaran, Katsiaryna Laziuk, Richard D. HammerAbstractThe World Health Organization (WHO) recognizes aggressive natural killer (NK)-cell leukemia and extranodal NK/T-cell lymphoma, nasal type as Epstein Barr Virus (EBV) associated lymphoproliferative disorders that may have overlapping features and must be distinguished from other T-cell lymphomas. A 35-year-old Hispanic female presented with fever of unknown origin, hemolysis and pancytopenia. Bone marrow biopsy with flow cytometry was negative for malignancy. Jejunal resec...
Source: Human Pathology: Case Reports - May 19, 2019 Category: Pathology Source Type: research
Large pleomorphic carcinoma of the lung: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Rusella Mirza, Mingxia ShiAbstractPleomorphic carcinoma (PC) of the lung is an aggressive carcinoma and an extremely rare entity. It is one of the subtypes of pulmonary sarcomatoid carcinoma. We are presenting a case of large PC with the relevant histological, immunohistochemical and molecular studies. A surgical specimen of a lung mass was obtained from a 74 year old female patient. The mass was 11 cm in its greatest dimension and was firmly attached to the pleura and diaphragm. Grossly the tumor was infiltrating to the surrounding s...
Source: Human Pathology: Case Reports - May 17, 2019 Category: Pathology Source Type: research
Dibothriocephalus nihonkaiensis infection identified by pathological and genetic analyses -a case report and a recent literature review of human diphyllobothriasis
We report a 20-year-old male with a past history of diarrhea and discharge of a strobila of a broad tapeworm from his anus 3 months ago. He again noticed passing a tapeworm strobila and he visited our hospital with the tapeworm sample. The macroscopic appearance and the pathological features strongly suggested Diphyllobothriasis. Soon after the first visit to our hospital, a capsule endoscopy was performed with the result of no evidence of strobilae or scoleces. Praziquantel at 20 mg/kg was orally administered once. Before drug administration, egg-like structures were present in the stool. They disappeared soon after d...
Source: Human Pathology: Case Reports - May 12, 2019 Category: Pathology Source Type: research
Incidental neuroendocrine tumor of the esophagus: A case report and review of the literature
We present a case of a 71 year old female with a history of Barrett's esophagus with high grade dysplasia that on screening endoscopy was found to have a squamous patch proximal to the gastroesophageal junction and underwent an endoscopic mucosal resection. Within the resection, there was a small tumor with a monomorphic population with speckled nuclear chromatin located within the lamina propria extending into the muscularis mucosae. The tumor measured 1 mm in greatest dimension and the overlying epithelium showed no evidence of the presence of Barrett's esophagus. Immunohistochemical staining of the tumor was consist...
Source: Human Pathology: Case Reports - May 11, 2019 Category: Pathology Source Type: research
Intramural great vessel lymphoma presenting as thrombus in an aortic aneurysm
We present the case of a 72-year-old man who presented with severe abdominal pain and was found to have thrombosed abdominal aortic aneurysm. The retrieved thrombus showed Epstein Barr virus-positive large B cell lymphoma (LBCL). Post-operative Echocardiography, Computerized tomography (CT) and Positron Emission Tomography (PET) scan did not show any residual tumor focus, abnormal mass or thickening, increased FDG uptake or hypermetabolism (Nodal or extranodal). This is the first case of large B cell lymphoma presenting as a thrombus within abdominal aortic aneurysm and third case of intramural great vessel lymphoma. (Sour...
Source: Human Pathology: Case Reports - March 10, 2019 Category: Pathology Source Type: research
“Circulating lobular breast carcinoma masquerading as acute leukemia”
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Meredith M. Nichols, Luis Malpica, Hyman B. Muss, Nathan D. Montgomery (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research
Late isolated metastasis of colon adenocarcinoma to the right ventricle
We present an exceedingly rare case of solitary metastasis of mucinous adenocarcinoma occupying 80% of the right ventricle and involving tricuspid valve, discovered 17 years after a diagnosis and treatment of a colon cancer. The patient's clinical presentation, diagnosis, and surgical management are detailed. This case provides evidence that late metastasizing colonic carcinoma and ventricular location of metastasis can and do occur. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research
Synaptophysin-positive nested stromal-epithelial tumor (NSET) of the liver in a 13-year-old male: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Zongshan Lai, Wei Li, Zakaria Aqel, Jacqueline K. MacknisAbstractNested stromal-epithelial tumor (NSET) of the liver is an extremely rare, newly described, nonhepatocytic, nonbiliary tumor of the liver with less than 40 cases reported in the literature to date [1].This tumor affects predominantly pediatric patients (2–34 years, mean age: 15.2 years, 69% female predominance). Imaging typically discloses a circumscribed heterogenous mass with foci of calcification. NSET has great clinical, radiologic and histologic overlap with many of ...
Source: Human Pathology: Case Reports - February 27, 2019 Category: Pathology Source Type: research
Rapidly progressive therapy-related myeloid neoplasm in a patient treated for Burkitt lymphoma: A case report
We present a case of a 44-year-old female who initially presented with Stage 4b, EBV-negative BL with classic morphological, immunophenotypic and cytogenetic features. The patient was treated with standard CODOX-M/IVAC chemotherapy (Cyclophosphamide, Doxorubicin, Vincristine, Methotrexate, Leucovorin, Ifosfamide, Etoposide, Cytarabine) plus Rituximab and achieved complete remission. She subsequently presented 2 years later with a t-MN which progressed to acute myeloid leukemia within 4 months.Fluorescence in situ hybridization studies (FISH) and cytogenetic studies post chemotherapy showed an abnormal mosaic female kar...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
