An indolent pancreatic ductal adenocarcinoma with psammoma bodies and a coincidental neuroendocrine tumor
In this report we will discuss a case of a very slow-growing pancreatic ductal adenocarcinoma arising in the neck/body with a coincidental neuroendocrine tumor in the tail. Prominent psammoma bodies are observed in the ductal carcinoma (absent in the neuroendocrine tumor). The presence of psammoma bodies within an indolent pancreatic ductal adenocarcinoma is very unusual and suggests a possible association with a favorable clinical course. Further study would be warranted to make a firm conclusion. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review
We report a case of fibrocartilaginous mesenchymoma (FCM) with multicystic changes in the fibrous component within the tumor, although the fibrous component usually shows cellular proliferation of spindle cells in the background of collagen fascicles. A 16-year-old boy complained of right knee pain after physical examination for several months. A bone tumor in the right proximal tibia was incidentally detected by plain radiography after a traffic accident. A surgical specimen obtained after enblock resection revealed irregular cartilaginous islands with enchondral ossification within the fibrous background and dominant cys...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Taisei Kurihara, Yoshiyuki Suehara, Keisuke Akaike, Takuo Hayashi, Taketo Okubo, Youngji Kim, Tatsuya Takagi, Kazuo Kaneko, Takashi Yao, Tsuyoshi SaitoAbstractAn 80-year-old man was diagnosed with squamous cell carcinoma (SCC) arising from chronic osteomyelitis in his right femur. The pathological findings of the amputated leg showed ulcerated tumor extending from the skin to the medullary cavity of the right femur in a continuous fashion. Metastasis in the left clavicle was also noticed 6 months after surgery, and the patient ultimatel...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
Carcinoma of the dorsum of the tongue with lung carcinoma and duodenal carcinoma in one patient
We present a case of SCC of the dorsum of the tongue along with the development of two other primary cancers with different histologies in a 61-year-old Japanese woman, who presented with a mass on the dorsum of her tongue in 2017. Intraoral examination revealed a 2.5 × 1.5-cm tumor on the dorsum of the tongue without induration and covered with normal epithelium. She was previously diagnosed with carcinoma in an adenoma of the duodenum in 2013 and adenocarcinoma of the right lung in 2016. Computed tomography and magnetic resonance imaging revealed no evidence of malignant tumors in the head and neck region. The lesio...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
High-grade transformation of papillary cystadenocarcinoma with p16 immunoreactivity arising from the base of tongue
Publication date: June 2019Source: Human Pathology: Case Reports, Volume 16Author(s): Katherine Larrabee, Jena C. Patel, Terrance J. Lynn, Iman Sarami, William QuinonesAbstractPapillary cystadenocarcinoma (PCC) is a rare malignant salivary gland neoplasm that accounts for less than 0.2% of primary salivary gland tumors. These tumors are characterized by the presence of invasive cystic and ductal structures and well-defined papillary endophytic projections with or without mucin production. PCC are generally low-grade indolent tumors with relatively low rate of regional lymph node metastasis. Since malignant tumors are rare,...
Source: Human Pathology: Case Reports - February 26, 2019 Category: Pathology Source Type: research
Gluteal region spindle cell variant embryonal rhabdomyosarcoma in infant treated with buttockectomy
ConclusionThe spindle cell embryonal rhabdomyosarcomas is a rare variant of embryonal subtype of RMS, occurring more commonly in children and adolescents. Its less aggressive sarcoma and better prognosis in children or adolescents, establish the correct diagnosis crucial using combination of clinical finding, histopathology and Immunohistochemistry. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - January 25, 2019 Category: Pathology Source Type: research
Successful treatment of gamma 1 heavy chain deposition disease with bortezomib and dexamethasone
We report the case of a 78-year-old female with HCDD who was successfully treated with bortezomib and dexamethasone (BD); histopathological improvements were confirmed by kidney biopsy after 2 years of chemotherapy. She presented with renal insufficiency, proteinuria, hematuria, hypogammaglobulinemia, and hypocomplementemia. Renal biopsy showed diffuse global nodular glomerulopathy with the deposition of IgG1 and C3 in the glomeruli and on the tubular basement membrane. Kappa and lambda light chains were not detected. Staining for the constant regions of the gamma heavy chain revealed the absence of the CH1 domain. These...
Source: Human Pathology: Case Reports - January 17, 2019 Category: Pathology Source Type: research
Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Sara Makhdoum, M. Ruhul Quddus, Michele M. Lomme, Katrine Hansen, W. Dwayne LawrenceAbstractA 63-year-old Caucasian woman underwent total hysterectomy with bilateral salpingo-oophorectomy due to abnormal uterine bleeding. Gross examination of the hysterectomy specimen revealed a large polypoid mass filling the endometrial cavity. Histological examination revealed a tumor with two unique morphologic patterns with no overlap or transition from one pattern to the other. The low-grade component consisted of FIGO grade 1 endometrioid adenocar...
Source: Human Pathology: Case Reports - January 8, 2019 Category: Pathology Source Type: research
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas arising from an intraductal papillary mucinous neoplasm
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Ahmad Charifa, Zenta Walther, Ronald R. Salem, Dhanpat JainAbstractUndifferentiated carcinoma of the pancreas with osteoclast-like giant cells is a rare pancreatic tumor of unclear origin. This case reports a 72-year-old male with bloating and indigestion for about six years who was found to have a 5 cm laterally spreading ampullary mass and a 1.3 cm solid and cystic distal pancreas body mass on esophagogastroduodenoscopy (EGD) and endoscopic ultrasound (EUS). Histological examination of the pancreatic mass showed an undifferentiated...
Source: Human Pathology: Case Reports - January 8, 2019 Category: Pathology Source Type: research
Pulmonary lymphangioleiomyomatosis with parietal pleural involvement: A case report and discussion of pathogenesis using pulmonary lymphangitic carcinomatosis as a model
We report a case of sporadic pulmonary lymphangioleiomyomatosis presenting with chylothorax and with parietal pleural involvement by the disease. The implications for the anatomic distribution of lesions in pulmonary lymphangioleiomyomatosis is discussed. The pathogenesis of pulmonary lymphangioleiomyomatosis is reviewed using pulmonary lymphangitic carcinomatosis as a model. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - January 4, 2019 Category: Pathology Source Type: research
Cryofibrinogen-associated glomerulonephritis diagnosed by mass spectrometry and immunoelectron microscopy
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Masanori Sudo, Yuichi Sakamaki, Michihiro Hosojima, Suguru Yamamoto, Yumi Ito, Naofumi Imai, Yoshikatsu Kaneko, Shin Goto, Chih-Ping Li, Akira Shimizu, Ichiei NaritaAbstractA 60-year-old male presented with accelerated hypertension, renal insufficiency, proteinuria, and hematuria. Percutaneous kidney biopsy revealed membranoproliferative glomerulonephritis (MPGN) without any immunoglobulin and complement deposition. On performing electron microscopy, deposits with a tubular, organized structure and approximately 60 nm in diameter were ...
Source: Human Pathology: Case Reports - January 3, 2019 Category: Pathology Source Type: research
A cotyledonoid dissecting leiomyoma with an intravascular component and adenomyosis accompanied with possible multiple lung metastases: A case report
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Jumpei Kashima, Akiko Tonooka, Ayumi Taguchi, Nobuaki Funata, Toshiharu Yasugi, Tsunekazu HishimaAbstractA cotyledonoid dissecting leiomyoma (CDL) is a rare variant of a uterine smooth muscle cell tumor and is characterized by intramural and extrauterine growth patterns with dissection of the uterine myometrium.We encountered a case of a CDL with multiple lung nodules. Computed tomographic and magnetic resonance imaging results revealed the presence of a multilobulated abdominal mass with cystic components contiguous to the uterine corpu...
Source: Human Pathology: Case Reports - January 1, 2019 Category: Pathology Source Type: research
Gastric CLTC-ALK fusion-positive inflammatory myofibroblastic tumor showing an endoscopic superficial depressed-type appearance
We present a 76-year-old Japanese male who had a history of removal of a gastric gastrointestinal stromal tumor (GIST) 6 years ago. Although asymptomatic and having no evidence of recurrence, follow-up endoscopy revealed a small, white depressed lesion of approximately 1 cm with converging mucosal folds in the greater curvature of the fundus, which was suspicious of depressed-type early gastric cancer (GC) by conventional endoscopy. However, no evidence of GC except a “white globe appearance”-like area was identified by magnifying endoscopy with blue laser imaging. The biopsy specimens showed a proliferation of ana...
Source: Human Pathology: Case Reports - December 26, 2018 Category: Pathology Source Type: research
Pacinian corpuscle in the prostate: Fact - not fiction!
Publication date: March 2019Source: Human Pathology: Case Reports, Volume 15Author(s): Shaun A.C. Medlicott, Erik T. Larsen, Yuan Gao, Kiril Trpkov (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - December 21, 2018 Category: Pathology Source Type: research
An unusual, poorly differentiated, neoplasm in a patient with an ASD closure device and bilateral adrenal involvement
We report a case of a 68-year old female patient, who initially presented with dyspnoea and bilateral lung nodules. While the symptoms were initially mild, the disease was clearly aggressive, and the patient passed away during workup. At autopsy, the disease was notable for involvement of multiple organs, with heavy intravascular tumour load. The patient's clinical history was notable for previous closure of an atrial septal defect (ASD), and, at autopsy, tumour thrombus was observed on the surface of the ASD closure device. The systemic tumour dissemination was attributed at least in part to the tumour laden thrombus in t...
Source: Human Pathology: Case Reports - November 23, 2018 Category: Pathology Source Type: research
