Unexpected DOG1 expression in gastrointestinal neuroectodermal tumor of the rectum: A diagnostic pitfall
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Cindy Bossenmeyer, Emilie Duchalais, Anne Moreau, Céline Bossard (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - July 4, 2019 Category: Pathology Source Type: research
Tropheryma whipplei endocarditis presenting as chronic valvular disease: A case report and review of literature
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Julia R. Naso, Davie Wong, Daniel R. Wong, Chien-Hung Chen, Linda M.N. HoangAbstractWhipple's endocarditis is a rare but treatable infectious disease. We discuss the diagnostic work-up of a case lacking classic endocarditis features. Current challenges in diagnosis and treatment of this under-recognized infection are highlighted. This case underscores the necessity of considering Whipple's endocarditis in the differential diagnosis for chronic valvular disease. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 29, 2019 Category: Pathology Source Type: research
Unusual neuroma of the adrenal medulla mimicking schwannoma and coexisting with an adrenocortical adenoma
We report an extremely rare case of incidentaloma in the adrenal medulla that was pathologically detected in an adrenal gland resected for cortical adenoma. The tumor in the medulla, measuring 5 mm in diameter, consisted of interlacing fascicles of Schwann cells and resembled a schwannoma. However, the tumor exhibited a very irregular contour and contained abundant nerve fiber bundles, which were positively immunostained for neurofilament protein, leading to the final diagnosis of neuroma. Although neural hypertrophy is rarely seen in the adrenal medulla, neuroma of the adrenal medulla has not been reported. We demonstra...
Source: Human Pathology: Case Reports - June 28, 2019 Category: Pathology Source Type: research
Metastatic well-differentiated neuroendocrine tumor in the breast: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Dongfang Yu, Yi ZhouAbstractMetastatic well-differentiated neuroendocrine tumors in the breast are rare and can be mistaken as invasive breast carcinoma due to their overlapping clinical, histological or radiological features. A 49-year-old female presented for evaluation of a left breast mass. Her past medical history was significant for an ileal well-differentiated neuroendocrine tumor with liver metastasis. Histology of breast biopsy shows nests of small uniform tumor cells with regularly dispersed chromatin. The tumor cells are p...
Source: Human Pathology: Case Reports - June 22, 2019 Category: Pathology Source Type: research
Blastic transformation of mantle cell lymphoma with B-lymphoblastic features
We present a case of mantle cell lymphoma with the typical phenotype, which transformed to a blastic morphology with loss of expression of CD20, CD5 and BCL2, and gain of CD10 and TdT. In cases presenting with blastic morphology, the use of CD10 and TdT in addition to the usual mantle cell lymphoma markers is essential since cases of mantle cell lymphoma with B-lymphoblastic features may require innovative treatment. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 20, 2019 Category: Pathology Source Type: research
Perineal nuchal-type fibroma originated from perirectal region: A case report
We report a 58-year-old man who presented with perineal nuchal-type fibroma originating in the perirectal region. This tumor was surgically excised; however, the fibrous band from tumor reached into levator ani muscle and was resected incompletely. Continuous follow up is needed even though this tumor is benign. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 20, 2019 Category: Pathology Source Type: research
Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Afnan Elsayed, Haneen Al-Maghrabi, Hosam Alardati, Ameen Alherabi, Abdelrazak Meliti (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research
Small bowel obstruction exacerbated by barium sulfate administration
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Whitney L. Reid, Jesse L. Cox, Karen L. Pennington, Philip McCarthy, Vishal M. Kothari, Samuel M. CohenAbstractSmall bowel obstruction (SBO) is a commonly encountered medical condition, typically a result of extrinsic causes, including post-operative adhesions. Less frequently, intrinsic and intraluminal factors may cause obstruction. Barium sulfate is a widely used contrast agent for radiography of suspected SBO, though it is rarely encountered in histologic sections and is an uncommon cause of SBO. Here, we present a case of a pati...
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research
Langerhans Cell Histiocytosis, Non-Langerhans histiocytosis and concurrent Papillary Thyroid Carcinoma with BRAF V600E mutations: A case report and literature review
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Laura Wake, Liqiang Xi, Mark Raffeld, Elaine S. Jaffe (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 19, 2019 Category: Pathology Source Type: research
Metanephric adenoma with osseous metaplasia and bone marrow elements
We present a case of a 75-year-old woman diagnosed with a metanephric adenoma with the unusual finding of associated bone and bone marrow elements. To our knowledge, this is the first case report of bone marrow elements seen in association with metanephric adenoma. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 14, 2019 Category: Pathology Source Type: research
Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors
We report a case of granulomatosis with polyangiitis (GPA) (Wegner's granulomatosis) who presented with multiple mass lesions in kidneys and lung lobes, as well as neck soft tissue, mimicking malignancies. This 71-year-old woman initially presented with sudden right foot drop, left calf pain and right eye vision loss. She was treated with corticosteroid for the diagnosis of possible temporal arteritis. Months after steroid was tapered to 2 mg per day, she developed increasing fatigue, weight loss, and shortness of breath. CT scan showed lung mass lesions in left upper lobe (3.8 × 2.4 cm), right mid lung with pleur...
Source: Human Pathology: Case Reports - June 11, 2019 Category: Pathology Source Type: research
Adult Langerhans cell histiocytosis arising in colonic polyp: A case report and literature review
In this report, we present a case of an adult female who was found to have a cecal polyp on a routine screening colonoscopy. The histopathological examination and immunohistochemical studies confirmed the diagnosis of LCH. We also review the literature of adults LCH manifested in GI mostly colonic polyps. (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - June 7, 2019 Category: Pathology Source Type: research
A case of clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) with two EWSR1-ATF1 fusions
We report a case of CCSLGT with two fusion transcripts of EWSR1-ATF1. A 60-year-old female received ileectomy because of repeated ileus history. A 30-mm submucosal tumor with mucosal ulceration was detected in the ileum. Histologically, sarcomatous tumor comprised relatively monomorphic tumor cells arranged in sheets or nests and several multinucleated osteoclast-like giant cells. The main tumor cells contain small round nuclei with prominent nucleoli and abundant clear cytoplasm. Immunohistochemistry, the tumor cells expressed S-100 protein diffusely and focally expressed CAM5.2, EMA, and CD56. They did not express HMB-45...
Source: Human Pathology: Case Reports - June 6, 2019 Category: Pathology Source Type: research
Anaplastic diffuse leptomeningeal glioneuronal tumor associated with H3 K27M mutation
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Shoh Sasaki, Takanori Hirose, Sumihito Nobusawa, Tomoya Myojin, Kohei Morita, Tokiko Nakai, Junko Hirato, Chiho Ohbayashi (Source: Human Pathology: Case Reports)
Source: Human Pathology: Case Reports - May 25, 2019 Category: Pathology Source Type: research
Multilocular cystic renal neoplasm of low malignant potential extending into the perinephric adipose tissue
Publication date: September 2019Source: Human Pathology: Case Reports, Volume 17Author(s): Khaled Abdelfattah Murshed, Mohammed Akhtar, Mohamed Ben-GashirAbstractMultilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare variant and a distinct subtype of clear cell renal cell tumors that has a favorable outcome. Most of the cases present with a low pathologic stage at diagnosis (T1 or T2). It is unusual for this tumor to extend into the perinephric adipose tissue, renal sinus fat or renal vein. There are very few cases reported in the literature to have a higher pathologic stage (pT3 and above) at di...
Source: Human Pathology: Case Reports - May 22, 2019 Category: Pathology Source Type: research
