Clinical data and practical experience related to Stribild as an option in patients with HIV infection
Publication date: Available online 16 April 2015 Source:HIV & AIDS Review Author(s): Miłosz Parczewski , Magdalena Witak-Jędra Single tablet combination of tenofovir disoproxil fumarate, emtricitabine, elvitegravir and cobicistat [TDF/FTC/EVG/COBI] has been licensed for the use in HIV infected individuals as Stribild®. In treatment naïve subjects high virological efficacy of the regimen was proved. Recently use of this combination has been investigated as the switch option for the virologically suppressed individuals without drug resistance to the components of the compound. In twin studies – STRATEGY-N...
Source: HIV and AIDS Review - April 25, 2015 Category: Infectious Diseases Source Type: research
Antibody response to VZV vaccination in HIV infected children
Conclusion Serological immune response to varicella vaccination in HIV-infected children was insufficient. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - April 25, 2015 Category: Infectious Diseases Source Type: research
Facial dystonia – A rare initial presentation of acquired immune deficiency syndrome
Publication date: Available online 31 March 2015 Source:HIV & AIDS Review Author(s): Arpit Saxena , A.V. Ramesh , Poonam Raj Mehra , Manoj S Movement disorders could be a neurological complication of acquired immune deficiency syndrome (AIDS) and may sometimes represent the initial manifestation of HIV (Human Immune Deficiency Virus) infection. Presented here is an unusual case of facial dystonia – as a presenting symptom of HIV. In this case no separate aetiology for facial dystonia other than HIV infection could be found. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - March 31, 2015 Category: Infectious Diseases Source Type: research
Disseminated Mycobacterium simiae manifested as IRIS: A case report
Publication date: Available online 18 March 2015 Source:HIV & AIDS Review Author(s): Uttiya Brahmachari , Saikat Saha , Binay Guchhait , Subhasish Kamal Guha Disseminated disease caused by Mycobacterium simiae, a nontubercular mycobacterium, has been rarely reported in medical literature. Infection from M. simiae is more common in immunocompromised patients. It can also present as immune reconstitution inflammatory syndrome in HIV infected subjects after initiation of highly active antiretroviral therapy. Here, we report a case of a middle aged lady infected with HIV, who presented with fever and cough afte...
Source: HIV and AIDS Review - March 19, 2015 Category: Infectious Diseases Source Type: research
Comparison of home and hospital deaths among patients on anti-retroviral therapy (ART): A clinical and verbal autopsy study
Conclusion Strategies for improving adherence, prevention and treatment of TB should be explored. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - March 13, 2015 Category: Infectious Diseases Source Type: research
HIV infection in the aspect of psychiatric practice
Publication date: Available online 9 March 2015 Source:HIV & AIDS Review Author(s): Magdalena Więdłocha , Piotr Marcinowicz , Bartłomiej Stańczykiewicz Presentation of the psychopathological signs and psychological dysfunctions associated with HIV infection is the aim of this review. Current neuropathological theories and psychiatric aspects of antiretroviral treatment have been outlined. Diagnostics and adequate treatment of psychiatric conditions concomitant to HIV infection are difficult because of the unspecific character of symptoms; thus, emphasis has been put on the characteristic psychopathologic...
Source: HIV and AIDS Review - March 9, 2015 Category: Infectious Diseases Source Type: research
A rare presentation of reversible ALS in HIV infection
Publication date: Available online 7 March 2015 Source:HIV & AIDS Review Author(s): Aju Abraham John , Suryanarayana Sharma , B.K. Madhusudhan , Rohan Mahale , Mahendra Javali , R. Srinivasa Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease (MND) [1]. It is usually associated with an irreversible course, and treatable causes of ALS are rare. Here, we present a case report of a 35-year-old male, with progressive weakness and wasting of muscles in all four limbs with fasciculation and electro diagnostic features compatible with a diagnosis of probable ALS. He was later diag...
Source: HIV and AIDS Review - March 7, 2015 Category: Infectious Diseases Source Type: research
The occurrence and characteristics of pain in HIV-1 positive persons – A challenge in the aging population
Conclusion Almost 40% of respondents reported chronic pain. We have found a strong correlation between age and chronic pain in the HIV infected population with the 7% increase in the odds of experiencing pain with each year of age. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - March 5, 2015 Category: Infectious Diseases Source Type: research
Toxoplasma gondii: A rare pathogen causing a neurological immune inflammatory reconstitution syndrome in HIV infected patient
We report a case of cerebral toxoplasmosis-IRIS in an HIV infected patient with a favorable outcome. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - March 4, 2015 Category: Infectious Diseases Source Type: research
Efficacy of genotypic drug resistance testing in patients with low-level plasma HIV-1 viremia
Conclusions Success rate for genotyping at low plasma viremia levels is high and allows to guide treatment optimization. As drug resistance is commonly found at low viral loads, genotyping should be attempted in every virologically failing patient regardless the plasma viremia. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - February 26, 2015 Category: Infectious Diseases Source Type: research
Assessment of long-term safety and effectiveness of atazanavir (ATV) in the first antiretroviral treatment regimen in POLCA cohort
Conclusion In POLCA cohort long term treatment with ATV was safe and effective, and observed drug-induced toxicities were similar or smaller than reported in literature. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - February 18, 2015 Category: Infectious Diseases Source Type: research
Neuro-endocrine immune networks leading to HIV-associated cardiovascular abnormalities: Role of leptin
Publication date: Available online 18 February 2015 Source:HIV & AIDS Review Author(s): T.N. Kathyayani , A. Harinatha Reddy , B. Sri Lakshmi , B. Venkatappa Patients infected with human immunodeficiency virus exhibit many risk factors like atherosclerosis, endothelial dysfunction and hypertension for cardiovascular disease. As the homeostatic mechanisms in body are regulated by the integrated actions of cytokines and hormones, the normal function of a human heart is also governed by the neuro-endocrine immune interactions. Patients suffering from acquired immunodeficiency syndrome manifest alterations in t...
Source: HIV and AIDS Review - February 18, 2015 Category: Infectious Diseases Source Type: research
Improvement of distal symmetrical polyneuropathy in patient with AIDS after switch from protease inhibitor containing antiretroviral treatment to tenofovir disoproxil fumarate, emtricitabine and rilpivirine (EVIPLERA®) therapy – Case report
Publication date: Available online 18 February 2015 Source:HIV & AIDS Review Author(s): Dariusz Bielec , Sławomir Kiciak , Anna Przybyła , Justyna Stempkowska In this paper we present a 29-year-old male patient with AIDS stage C3 according to CDC (esophageal candidiasis). He received combined antiretroviral therapy (cART) with lopinavir/ritonavir and tenofovir disoproxil fumarate/emtricitabine. Almost 2log reduction of viral load was observed after 1 month of cART, but the patient developed distal symmetrical polyneuropathy. Therapy was switched to tenofovir disoproxil fumarate/emtricitabine/rilpivirine (...
Source: HIV and AIDS Review - February 18, 2015 Category: Infectious Diseases Source Type: research
An unusual presentation: A case of Multicentric Castleman's disease presenting as bilateral pleural effusions
Publication date: Available online 14 February 2015 Source:HIV & AIDS Review Author(s): Priya K. Simoes , Narender Annapureddy , Vaidehi Avadhani , Gangajal Kasnia , Girish N. Nadkarni A 30-year-old male with AIDS with worsening dyspnea and leg swelling, extensive lymphadenopathy and anasarca. CT revealed new pleural effusions and lymphadenopathy. Lymph node biopsy showed Multicentric Castleman's disease with Kaposi's sarcoma. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - February 14, 2015 Category: Infectious Diseases Source Type: research
Metabolic abnormalities and cardiovascular risk in HIV-infected cohort of patients treated with protease inhibitors
Conclusion The study confirms differences in CV risk factors between different cART drugs and this should be considered during initiation of the therapy. (Source: HIV and AIDS Review)
Source: HIV and AIDS Review - November 22, 2014 Category: Infectious Diseases Source Type: research
