Improvement of distal symmetrical polyneuropathy in patient with AIDS after switch from protease inhibitor containing antiretroviral treatment to tenofovir disoproxil fumarate, emtricitabine and rilpivirine (EVIPLERA®) therapy – Case report

Publication date: Available online 18 February 2015 Source:HIV & AIDS Review Author(s): Dariusz Bielec , Sławomir Kiciak , Anna Przybyła , Justyna Stempkowska In this paper we present a 29-year-old male patient with AIDS stage C3 according to CDC (esophageal candidiasis). He received combined antiretroviral therapy (cART) with lopinavir/ritonavir and tenofovir disoproxil fumarate/emtricitabine. Almost 2log reduction of viral load was observed after 1 month of cART, but the patient developed distal symmetrical polyneuropathy. Therapy was switched to tenofovir disoproxil fumarate/emtricitabine/rilpivirine (EVIPLERA®). During this therapy HIV-RNA became undetectable, CD4 T cell count increased and distal symmetrical polyneuropathy symptoms improved and then disappeared completely. Therapy was well tolerated and no laboratory abnormalities were observed.
Source: HIV and AIDS Review - Category: Infectious Diseases Source Type: research