Drug Discovery Today: Disease Models This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genetically modified mouse models of cancer invasion and metastasis
Publication date: Autumn 2011 Source:Drug Discovery Today: Disease Models, Volume 8, Issues 2–3 Author(s): Paulina Rampetsreiter , Emilio Casanova , Robert Eferl Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investiga...
Source: Drug Discovery Today: Disease Models - November 1, 2014 Category: Drugs & Pharmacology Source Type: research

Polymicrobial sepsis models: CLP versus CASP
Publication date: Spring 2012 Source:Drug Discovery Today: Disease Models, Volume 9, Issue 1 Author(s): Gernot Schabbauer Sepsis is a disease syndrome covering many different aspects of the host immune system. Our understanding of sepsis is still incomplete. Several animal models of sepsis have been developed and much of our current knowledge on the molecular basis of the disease has originated from these models. Two of the most reliable and clinically relevant rodent models to mimic human sepsis in the animal model are cecal ligation and puncture (CLP) and colon ascendens stent peritonitis (CASP). (Source: Drug Disco...
Source: Drug Discovery Today: Disease Models - November 1, 2014 Category: Drugs & Pharmacology Source Type: research