Genetically modified mouse models of cancer invasion and metastasis

Publication date: Autumn 2011 Source:Drug Discovery Today: Disease Models, Volume 8, Issues 2–3 Author(s): Paulina Rampetsreiter , Emilio Casanova , Robert Eferl Tumor invasion and metastasis is a multi-step process that requires adaptation of cancer cells to conditions that they encounter during their journey to distant body sites. Understanding the molecular processes that underlie this adaptation is of exceeding importance because most cancer patients die because of metastases rather than primary tumors. In this review we assess genetically engineered mouse models (GEMMs) that have been established to investigate mechanisms of cancer invasion and metastasis.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research