Drug Discovery Today: Disease Models This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Computational models of blood disorders
Publication date: Available online 20 February 2016 Source:Drug Discovery Today: Disease Models Author(s): George Em Karniadakis (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - February 20, 2016 Category: Drugs & Pharmacology Source Type: research

Animal models of bone disease and repair
Publication date: Autumn 2014 Source:Drug Discovery Today: Disease Models, Volume 13 Author(s): Oskar Hoffmann (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - January 12, 2016 Category: Drugs & Pharmacology Source Type: research

Multi-scale biological and physical modelling of the tumour micro-environment
Publication date: Available online 20 July 2015 Source:Drug Discovery Today: Disease Models Author(s): Robert F. Kunz, Byron J. Gaskin, Qunhua Li, Sam Davanloo-Tajbakhsh, Cheng Dong Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) intera...
Source: Drug Discovery Today: Disease Models - July 20, 2015 Category: Drugs & Pharmacology Source Type: research

In silico modeling of malaria and sickle-cell disease
Publication date: Available online 10 June 2015 Source:Drug Discovery Today: Disease Models Author(s): Dmitry A. Fedosov In silico modeling of hematologic diseases and disorders (e.g., malaria, sickle cell anemia) has proved to make a significant contribution to the understanding of various disease processes and their progression. This review presents a general computational framework for modeling blood flow on a single cell level applied here to malaria and sickle cell disease. The computational disease model is validated using several independent experimental results. The simulation approach is general enough to ad...
Source: Drug Discovery Today: Disease Models - June 11, 2015 Category: Drugs & Pharmacology Source Type: research

Mass spectrometry analysis of histone post translational modifications
Publication date: Available online 27 April 2015 Source:Drug Discovery Today: Disease Models Author(s): Thomas C. Minshull , Mark J. Dickman Histone proteins play a central role in the dynamic structure of chromatin within the cell nucleus. The post translational modifications of histones can perturb chromatin contacts and the recruitment of non-histone proteins to chromatin. Alterations in the chromatin structure in which DNA is packaged influences the assembly of enzyme complexes that subsequently manipulate DNA. Therefore, such modifications may affect a wide range of biological processes which are potentially epi...
Source: Drug Discovery Today: Disease Models - April 27, 2015 Category: Drugs & Pharmacology Source Type: research

Animal models in bone repair
Publication date: Available online 4 March 2015 Source:Drug Discovery Today: Disease Models Author(s): Brigitte von Rechenberg Animal models in fracture repair comprise different species and a numerous variety of fixation devices. There are no standardized models around making comparisons between studies difficult. In recent years molecular mechanisms of fracture repair are investigated mainly in genetically modified mice and also in rats using biomimetic agents to accelerate fracture repair, but translation to clinical use is not yet available. In this update species relevant questions are addressed from the experien...
Source: Drug Discovery Today: Disease Models - March 4, 2015 Category: Drugs & Pharmacology Source Type: research

Computational models of lung diseases
Publication date: Available online 29 January 2015 Source:Drug Discovery Today: Disease Models Author(s): Merryn H. Tawhai , Jason H.T. Bates (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - January 30, 2015 Category: Drugs & Pharmacology Source Type: research

Computational models of heart disease
Publication date: Available online 12 January 2015 Source:Drug Discovery Today: Disease Models Author(s): Nic Smith , Natalia Trayanova (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - January 19, 2015 Category: Drugs & Pharmacology Source Type: research

Bone pathology in murine models of inflammatory arthritis
Publication date: Available online 12 January 2015 Source:Drug Discovery Today: Disease Models Author(s): Jochen Zwerina , Bastian Oppl Inflammatory joint diseases such as rheumatoid arthritis and spondyloarthritides are closely linked to structural bone damage and deterioration of functional capacity in affected individuals. These diseases not only cause local damage but are also associated with systemic bone loss. Several animal models of chronic arthritis have been invented in the past. This review gives a summary on the most commonly used models with emphasis on recent advances in the understanding of the pathoph...
Source: Drug Discovery Today: Disease Models - January 19, 2015 Category: Drugs & Pharmacology Source Type: research

Animal models of renal disease
Publication date: Available online 14 January 2015 Source:Drug Discovery Today: Disease Models Author(s): Charles E. Alpers (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - January 19, 2015 Category: Drugs & Pharmacology Source Type: research

Impact of senescence on bone quality: lessons from animal models of aging
Publication date: Available online 1 December 2014 Source:Drug Discovery Today: Disease Models Author(s): Peter J. Richards The association of osteoporotic bone loss and fracture risk with age is becoming increasingly more apparent as the population pyramid continues to shift toward old age. Elucidation of the underlying mechanisms controlling skeletal aging is therefore considered to be of paramount importance in the development of effective therapeutic strategies with which to treat age-related osteoporosis. In this regard, mouse models of premature aging represent an ideal means by which to study the development an...
Source: Drug Discovery Today: Disease Models - December 2, 2014 Category: Drugs & Pharmacology Source Type: research

A review of mathematical models for leukemia and lymphoma
This article reviews the recent contributions of mathematical modeling to leukemia and lymphoma research. These developments suggest that mathematical modeling has great potential in this field. Collaboration between mathematicians, clinicians, and experimentalists can significantly improve leukemia and lymphoma therapy. (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - November 30, 2014 Category: Drugs & Pharmacology Source Type: research

Intrauterine growth retardation – a developmental model of type 2 diabetes
Publication date: Summer 2013 Source:Drug Discovery Today: Disease Models, Volume 10, Issue 2 Author(s): Sara E. Pinney Intrauterine growth retardation (IUGR) has been linked to the development of type 2 diabetes later in life and the mechanisms underlying this phenomena are unknown. Epidemiological studies in humans show a distinct link with the exposure to an intrauterine insult that results in low birth weight and the development of type 2 diabetes in adulthood. IUGR can be induced in rodent models by exposing the pregnant rat to a low protein diet, total calorie restriction, high dose glucocorticoids or inducing u...
Source: Drug Discovery Today: Disease Models - November 14, 2014 Category: Drugs & Pharmacology Source Type: research

Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities
Publication date: Summer 2013 Source:Drug Discovery Today: Disease Models, Volume 10, Issue 2 Author(s): Sayaka Watanabe , Fan-Yan Wei , Kazuhito Tomizawa Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1. (Source: Drug Discovery Today: Disease Models)
Source: Drug Discovery Today: Disease Models - November 14, 2014 Category: Drugs & Pharmacology Source Type: research

Cellular and animal models of type 2 diabetes GWAS gene polymorphisms: what can we learn?
Publication date: Summer 2013 Source:Drug Discovery Today: Disease Models, Volume 10, Issue 2 Author(s): Guy A. Rutter Genome-wide association studies (GWAS) have revealed multiple loci associated with increased type 2 diabetes (T2D) risk. Genes in the affected loci are likely therefore to play a role in disease aetiology, and may ultimately provide targets for intervention. The majority of identified polymorphisms alter insulin production, and often lie between or within several known genes. Determining which gene(s) contribute(s) to disease risk is likely to require complementary human, animal and cellular studies. ...
Source: Drug Discovery Today: Disease Models - November 14, 2014 Category: Drugs & Pharmacology Source Type: research