Diagnostic Microbiology and Infectious Disease This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of cefazolin co-administration with vancomycin to reduce development of vancomycin-intermediate Staphylococcus aureus
Development of antimicrobial resistance during monotherapy of complicated methicillin-resistant Staphylococcus aureus bacteremia is problematic due to cross-resistance between vancomycin (VAN) and daptomycin, the only approved agents for this condition. Our objective was to demonstrate that development of resistance under conditions of suboptimal VAN (200  mg q 12 h) exposure in S. aureus can be attenuated by addition of cefazolin (CFZ). (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 7, 2018 Category: Microbiology Authors: Nivedita B. Singh, Juwon Yim, Seyedehameneh Jahanbakhsh, George Sakoulas, Michael J. Rybak Source Type: research

Clinical Impact of a Rapid Streptococcal Antigen Test on Antibiotic Use in Adult Patients
Adult pharyngitis is rarely attributable to group A streptococci. Utilization of a rapid streptococcal antigen test (RADT) may improve appropriate prescribing for bacterial pharyngitis. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 7, 2018 Category: Microbiology Authors: Monique Dodd, Allen Adolphe, Alisha Parada, Meghan Brett, Karissa Culbreath, Ren ée-Claude Mercier Source Type: research

Impact of Cefazolin Co-administration with Vancomycin to Reduce Development of Vancomycin Intermediate Staphylococcus aureus
Development of antimicrobial resistance during monotherapy of complicated methicillin-resistant Staphylococcus aureus bacteremia is problematic due to cross-resistance between vancomycin (VAN) and daptomycin, the only approved agents for this condition. Our objective was to demonstrate that development of resistance under conditions of sub-optimal VAN (200mg q 12h) exposure in S. aureus can be attenuated by addition of cefazolin (CFZ). (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 7, 2018 Category: Microbiology Authors: Nivedita B. Singh, Juwon Yim, Seyedehameneh Jahanbakhsh, George Sakoulas, Michael J. Rybak Source Type: research

Diagnosing candidemia with the T2Candida panel: An instructive case of septic shock in which blood cultures were negative
T2Candida that was positive for C. albicans/C.tropicalis supported antifungal treatment of a patient with hematogenously disseminated candidiasis and septic shock, in whom blood cultures were negative. T2Candida, used and interpreted as a Bayesian biomarker, can identify patients with candidemia who are missed by blood cultures, including those receiving antifungal treatment. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 5, 2018 Category: Microbiology Authors: Cornelius J. Clancy, M. Hong Nguyen Tags: Note Source Type: research

Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward
Patients with respiratory infections are often managed presumptively until confirmation of infection status. We assessed the impact of introducing the Enigma ® MiniLab™ FluAB-RSV point-of-care test (POCT) on patients admitted with a suspected respiratory virus driven illness in an acute pediatric ward. This utilized a before and after design (respiratory viral seasons 2013/14 versus 2014/15). Following POCT implementation, oseltamivir prescribing incr eased in patients with influenza (OR = 12.7, P = 0.05, 95% CI [1.0, 153.8]). (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 4, 2018 Category: Microbiology Authors: Andres I. Vecino-Ortiz, Simon D. Goldenberg, Sam T. Douthwaite, Chih-Yuan Cheng, Rebecca E. Glover, Catherine Mak, Elisabeth J. Adams Source Type: research

Outcome of Facial Palsy from Lyme Disease in Prospectively Followed Patients Who Had Received Corticosteroids
Although a short course of corticosteroid therapy has been shown to improve the outcome of idiopathic facial nerve palsy (Bell's palsy), it is unclear whether corticosteroids, in addition to antibiotic therapy, are beneficial, harmful or have no impact on the outcome of facial palsy from Lyme disease (LDFP). From 2011 through 2016, 14 patients with LDFP were enrolled into a prospective study to determine the outcome of Lyme disease over the ensuing 12months. Eleven (78.6%) had received corticosteroids in addition to oral antibiotics and entered the study within 24days after onset of the LDFP (median 14days, range 2 –24da...
Source: Diagnostic Microbiology and Infectious Disease - April 4, 2018 Category: Microbiology Authors: Gary P. Wormser, N.P. Donna McKenna, R.N. Carol Scavarda, Carol Karmen Source Type: research

Impact of a multiplex PCR point-of-care test for influenza A/B and respiratory syncytial virus on an acute pediatric hospital ward
Patients with respiratory infections are often managed presumptively until confirmation of infection status. We assessed the impact of introducing the Enigma ® MiniLab™ FluAB-RSV point-of-care test (POCT) on patients admitted with a suspected respiratory virus driven illness in an acute pediatric ward. This utilized a before (respiratory viral season 2013/14) and after (respiratory viral season 2014/15) design. Following POCT implementation, oseltamiv ir prescribing increased in patients with influenza (OR=12.7, p=0.05, 95% CI [1.0, 153.8]). (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - April 4, 2018 Category: Microbiology Authors: Andres I. Vecino-Ortiz, Simon D Goldenberg, Sam T Douthwaite, Chih-Yuan Cheng, Rebecca E Glover, Catherine Mak, Elisabeth J Adams Source Type: research

Comparison of disk diffusion and agar dilution methods for gentamicin susceptibility testing of Neisseria gonorrhoeae
Gentamicin is a promising antibiotic for the treatment of multidrug-resistant gonorrhea. International guidelines do not list breakpoints for gentamicin. However, tentative susceptibility breakpoints for MIC and disk diffusion methods have been proposed. The aim of this study was to analyze the suitability and reliably of disk diffusion to monitor the susceptibility to gentamicin. We studied 237Neisseria gonorrhoeae isolates obtained in 2013 and 2015. The MIC and disk diffusion methods were performed according to CLSI guidelines. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 29, 2018 Category: Microbiology Authors: Ricardo Gianecini, Claudia Oviedo, Lucia Irazu, Marcelo Rodr íguez, GASSP-AR Working Group, Patricia Galarza Source Type: research

Comparison of 4 commercially available group B Streptococcus molecular assays using remnant rectal –vaginal enrichment broths
The incidence of neonatal Group B streptococcal (GBS) disease has significantly declined since the widespread implementation of prenatal screening of expectant mothers for urogenital and gastrointestinal tract GBS colonization. Screening methods have evolved from exclusively culture-based approaches to more rapid and highly sensitive molecular methods. We chose to evaluate the performance of 4 commercially available GBS molecular tests for detection of GBS colonization using 299 antepartum rectal –vaginal specimens submitted to our laboratory for routine GBS screening. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 28, 2018 Category: Microbiology Authors: Ryan F. Relich, Rebecca J. Buckner, Christopher L. Emery, Thomas E. Davis Source Type: research