Impact of Cefazolin Co-administration with Vancomycin to Reduce Development of Vancomycin Intermediate Staphylococcus aureus

Development of antimicrobial resistance during monotherapy of complicated methicillin-resistant Staphylococcus aureus bacteremia is problematic due to cross-resistance between vancomycin (VAN) and daptomycin, the only approved agents for this condition. Our objective was to demonstrate that development of resistance under conditions of sub-optimal VAN (200mg q 12h) exposure in S. aureus can be attenuated by addition of cefazolin (CFZ).
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Source Type: research