Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study.
CONCLUSION: This is the first study reporting a gender-specific interaction between ABCA1/R230C variant and dietary carbohydrate and fat percentages affecting VAT/SAT ratio, GGT, ALP, adiponectin levels and HOMA index. Our study confirmed the previously reported gender-specific ABCA1-diet interaction affecting HDL-C levels observed in an independent study. Our results show how gene-environment interactions may help further understand how certain gene variants confer metabolic risk, and may provide information useful to design diet intervention studies.
PMID: 26579206 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Jacobo-Albavera L, Posadas-Romero C, Vargas-Alarcón G, Romero-Hidalgo S, Posadas-Sánchez R, González-Salazar MD, Carnevale A, Canizales-Quinteros S, Medina-Urrutia A, Antúnez-Argüelles E, Villarreal-Molina T Tags: Nutr Metab (Lond) Source Type: research
Evaluation of Bone Mineral Density and Bone Biomarkers in Patients With Type 2 Diabetes Treated With Canagliflozin.
CONCLUSIONS: In older patients with T2DM, canagliflozin showed small but significant reductions in total hip BMD and increases in bone formation and resorption biomarkers, due at least in part to weight loss.
PMID: 26580234 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Bilezikian JP, Watts NB, Usiskin K, Polidori D, Fung A, Sullivan D, Rosenthal N Tags: J Clin Endocrinol Metab Source Type: research
Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity.
CONCLUSIONS: Enhanced satiety gut hormone responses after RYGB may be a causative mechanism by which anatomical alterations of the gut in obesity surgery modify behavioral and brain reward responses to food.
PMID: 26580235 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Goldstone AP, Miras AD, Scholtz S, Jackson S, Neff KJ, Pénicaud L, Geoghegan J, Chhina N, Durighel G, Bell JD, Meillon S, le Roux CW Tags: J Clin Endocrinol Metab Source Type: research
Social Jetlag, Chronotype, and Cardiometabolic Risk.
CONCLUSION: Our findings suggest that a misalignment of sleep timing is associated with metabolic risk factors that predispose to diabetes and atherosclerotic cardiovascular disease.
PMID: 26580236 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB Tags: J Clin Endocrinol Metab Source Type: research
Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus.
CONCLUSIONS: Fracture risk was increased with canagliflozin treatment, driven by CANVAS patients, who were older, with prior history/risk of cardiovascular disease, and with lower baseline eGFR and higher baseline diuretic use. The increase in fractures may be mediated by falls; however, the cause of increased fracture risk with canagliflozin is unknown.
PMID: 26580237 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Watts NB, Bilezikian JP, Usiskin K, Edwards R, Desai M, Law G, Meininger G Tags: J Clin Endocrinol Metab Source Type: research
A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism.
CONCLUSION: A novel aldosterone-producing pathology, pAATL that causes unilateral PA, was detected in the adrenals of 2 patients. NGS analyses of the large pAATLs suggested that the introduction of APA-associated mutations in the ion channel/pump genes may be involved in the development of mAPA from existing APCCs.
PMID: 26580238 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K Tags: J Clin Endocrinol Metab Source Type: research
A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes.
CONCLUSION: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to people at risk of diabetes, which warrant further investigation.
PMID: 26571012 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Guess ND, Dornhorst A, Oliver N, Frost GS Tags: Ann Nutr Metab Source Type: research
White matter microstructure and cognitive function in young women with polycystic ovary syndrome.
CONCLUSIONS: White matter microstructure is altered, and cognitive performance is compromised, in young adults with PCOS. These alterations in brain structure and function are independent of age, education and body mass index. If reversible, these changes represent a potential target for treatment.
PMID: 26574952 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Rees DA, Udiawar M, Berlot R, Jones DK, O'Sullivan MJ Tags: J Clin Endocrinol Metab Source Type: research
Dual 5-alpha reductase inhibition promotes hepatic lipid accumulation in man.
CONCLUSIONS: Dual SRD5A inhibition with Dutasteride is associated with increased intrahepatic lipid accumulation.
PMID: 26574953 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW Tags: J Clin Endocrinol Metab Source Type: research
Obesity is associated with low NAD(+)/SIRT pathway expression in adipose tissue of BMI-discordant monozygotic twins.
CONCLUSIONS: Our data highlight a strong relationship of reduced NAD(+)/SIRT pathway expression with acquired obesity, inflammation, insulin resistance, and impaired mitochondrial protein homeostasis in SAT.
PMID: 26574954 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Jukarainen S, Heinonen S, Rämö JT, Rinnankoski-Tuikka R, Rappou E, Tummers M, Muniandy M, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pirinen E, Pietiläinen KH Tags: J Clin Endocrinol Metab Source Type: research
Biomarkers of ectopic fat deposition: the next frontier in serum lipidomics.
CONCLUSIONS: Different serum lipids predict intramuscular TAG accumulation in obese people vs. athletes. The ability of serum lipidomics to predict intramuscular DAG and ceramide in insulin-resistant humans may prove a new biomarker to determine risk for diabetes.
PMID: 26574956 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC Tags: J Clin Endocrinol Metab Source Type: research
Female Physicians and the Future of Endocrinology.
CONCLUSIONS: Endocrinology is predicted to become the most female-predominant subspecialty of internal medicine. The specialty of endocrinology should take a lead role in advocating for changes that support the success of female physicians. Strengthening and supporting the physician workforce can only serve to attract talented physicians of both genders to the specialty, which will be key to meeting the needs of the increasing numbers of patients with endocrine disorders.
PMID: 26574957 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Pelley E, Danoff A, Cooper DS, Becker C Tags: J Clin Endocrinol Metab Source Type: research
Cerebrovascular Complications of Diabetes: Alpha Glucosidase Inhibitor as Potential Therapy.
Abstract
Increased risk of cerebrovascular accident in diabetes cannot be fully explained by traditional risk factors. Epidemiological studies show that postprandial hyperglycemia is strongly associated with cerebrovascular events and cerebrovascular-associated mortality. Postprandial hyperglycemia contributes to vascular damage by several mechanisms such as endothelial dysfunction, arthrosclerosis, oxidative stress, inflammation, and hypercoagulability. Hyperglycemia has deleterious effects on the vascular endothelium and leads to the development of cerebrovascular disease. Thus, an important strategy to ...
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Patel SS Tags: Horm Metab Res Source Type: research
Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes.
CONCLUSIONS: In contrast to glycemic parameters, serum levels of sRAGE were negatively correlated with body measurements indicative of obesity in the prediabetic state. In addition, the negative correlation with LDL cholesterol levels suggests that sRAGE has a more robust association with metabolic syndrome than with prediabetes.
PMID: 26569122 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 16, 2015 Category: Endocrinology Authors: Guclu M, Ali A, Eroglu DU, Büyükuysal SO, Cander S, Ocak N Tags: Metab Syndr Relat Disord Source Type: research
Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion.
We describe a case where metanephrine was measured during AVS to successfully circumvent this problem. A 55-year-old hypertensive male had raised plasma aldosterone/renin ratios and PA confirmed by fludrocortisone suppression testing. Failure of plasma cortisol to suppress overnight following dexamethasone and persistently suppressed corticotrophin were consistent with adrenal hypercortisolism. On AVS, comparison of adrenal and peripheral A/F ratios (left 5.7 vs peripheral 1.0; right 1.7 vs peripheral 1.1) suggested bilateral aldosterone production, with the left gland dominant but without contralateral suppression. Howeve...
Source: Diabetes Metab - November 15, 2015 Category: Endocrinology Authors: Goupil R, Wolley M, Ungerer J, McWhinney B, Mukai K, Naruse M, Gordon RD, Stowasser M Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
