Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus.

CONCLUSIONS: Fracture risk was increased with canagliflozin treatment, driven by CANVAS patients, who were older, with prior history/risk of cardiovascular disease, and with lower baseline eGFR and higher baseline diuretic use. The increase in fractures may be mediated by falls; however, the cause of increased fracture risk with canagliflozin is unknown. PMID: 26580237 [PubMed - as supplied by publisher]
Source: Diabetes Metab - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research