A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism.

CONCLUSION: A novel aldosterone-producing pathology, pAATL that causes unilateral PA, was detected in the adrenals of 2 patients. NGS analyses of the large pAATLs suggested that the introduction of APA-associated mutations in the ion channel/pump genes may be involved in the development of mAPA from existing APCCs.
PMID: 26580238 [PubMed - as supplied by publisher]

Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K Tags: J Clin Endocrinol Metab Source Type: research