The role of Obestatin in Roux-en-Y gastric bypass-induced remission of Type 2 Diabetes Mellitus.
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PMID: 26445403 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 7, 2015 Category: Endocrinology Authors: Wang JL, Xu XH, Zhang XJ, Li WH Tags: Diabetes Metab Res Rev Source Type: research
The genetic variant I148M in PNPLA3 is associated with increased hepatic retinyl-palmitate storage in humans.
CONCLUSIONS: The increased content of hepatic retinyl-palmitate and the reduced ratio of retinol/retinyl-palmitate in PNPLA3 I148M minor allele carriers support in vitro findings of an altered retinyl-palmitate lipase activity. Our results indicate that the PNPLA3 I148M variant is relevant for the retinyl-palmitate content in human liver providing a possible link to chronic liver disease.
PMID: 26439088 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 6, 2015 Category: Endocrinology Authors: Kovarova M, Königsrainer I, Königsrainer A, Machicao F, Häring HU, Schleicher E, Peter A Tags: J Clin Endocrinol Metab Source Type: research
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
Abstract
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to discuss recent insights regarding the developmental line...
Source: Diabetes Metab - October 6, 2015 Category: Endocrinology Authors: Kajimura S, Spiegelman BM, Seale P Tags: Cell Metab Source Type: research
Effect of high-dose atorvastatin on the cardiovascular risk associated with individual components of metabolic syndrome: A subanalysis of the Treating to New Targets (TNT) study.
CONCLUSIONS: Treatment with high-dose atorvastatin to a mean LDL-C level of 2.0 mmol/l (77 mg/dl) considerably attenuated the predictive power associated with three MetS components.
PMID: 26434404 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Deedwania PC, Shepherd J, Breazna A, DeMicco DA Tags: Diabetes Obes Metab Source Type: research
Early renin-angiotensin-system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes.
CONCLUSIONS: RAS intervention early in the course of proteinuric DKD is more beneficial than late intervention in delaying ESRD.
PMID: 26434564 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Schievink B, Kröpelin T, Mulder S, Parving HH, Remuzzi G, Dwyer J, Vemer P, de Zeeuw D, Heerspink HL Tags: Diabetes Obes Metab Source Type: research
Evaluation of Immunogenicity of LY2963016 Insulin Glargine Compared with Lantus® Insulin Glargine in Patients with Type 1 Diabetes Mellitus or Type 2 Diabetes Mellitus.
CONCLUSIONS: LY IGlar and IGlar have similar immunogenicity profiles; anti-insulin glargine antibody levels were low for both treatments with no observed effect on efficacy and safety outcomes.
PMID: 26434665 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Ilag LL, Deeg MA, Costigan T, Hollander P, Blevins TC, Edelman SV, Konrad RJ, Ortmann RA, Pollom RK, Huster WJ, Zielonka JS, Prince MJ Tags: Diabetes Obes Metab Source Type: research
Glucagon Increases Energy Expenditure Independently of Brown Adipose Tissue Activation in Humans.
CONCLUSIONS: Glucagon increases energy expenditure to a similar magnitude compared to cold activation, but independently of BAT thermogenesis. This finding is of importance for the development of safe treatments of obesity through upregulation of energy expenditure.
PMID: 26434748 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos A, Buckley A, Win Z, Al-Nahhas A, Rabiner EA, Gunn RN, Bloom SR, Tan TM, Dhillo WS Tags: Diabetes Obes Metab Source Type: research
AMG 151 (ARRY-403), a Novel Glucokinase Activator, Decreases Fasting and Postprandial Glycemia in Patients With Type 2 Diabetes.
Abstract
Phase 1 studies have demonstrated that AMG 151 activates glucokinase, a key enzyme in glucose homeostasis. This randomized, placebo-controlled phase 2a study evaluated the dose-effect relationship of the glucokinase activator AMG 151 relative to placebo on fasting plasma glucose (FPG) in 236 patients (n=33-35/arm) with type 2 diabetes treated with metformin. Patients received oral AMG 151 at 50, 100, or 200 mg twice daily (BID); AMG 151 at 100, 200, or 400 mg once daily (QD); or matching placebo for 28 days. A significant linear dose-effect trend was observed with the BID regimen (p = 0.004) f...
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Katz L, Manamley N, Snyder W, Dodds M, Agafonova N, Sierra-Johnson J, Cruz M, Kaur P, Mudaliar S, Raskin P, Kewalramani R, Pellacani A Tags: Diabetes Obes Metab Source Type: research
Effects of common chronic medical conditions on psychometric tests used to diagnose minimal hepatic encephalopathy.
Abstract
Many chronic medical conditions are accompanied by cognitive disturbances but these have only to a very limited extent been psychometrically quantified. An exception is liver cirrhosis where hepatic encephalopathy is an inherent risk and mild forms are diagnosed by psychometric tests. The preferred diagnostic test battery in cirrhosis is often the Continuous Reaction Time (CRT) and the Portosystemic Encephalopathy (PSE) tests but the effect on these of other medical conditions is not known. We aimed to examine the effects of common chronic (non-cirrhosis) medical conditions on the CRT and PSE test...
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Lauridsen MM, Poulsen L, Rasmussen CK, Høgild M, Nielsen MK, de Muckadell OB, Vilstrup H Tags: Metab Brain Dis Source Type: research
The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery.
In this study we included sixty women with a mean age of 47 ± 10 years studied 7 ± 2 years after bariatric surgery. The variables studied were bone mineral density, β-isomer of C-terminal telopeptide of type I collagen cross-links (a bone resorption marker), the bone formation markers osteocalcin and N-terminal propeptide of procollagen 1, serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand. Serum osteoprotegerin inversely correlated with the bone remodeling markers osteocalcin, β-isomer of C-terminal telopeptide of type I collagen cross-links and N-terminal propeptide of procollagen 1. The ...
Source: Diabetes Metab - October 5, 2015 Category: Endocrinology Authors: Balsa JA, Lafuente C, Gómez-Martín JM, Galindo J, Peromingo R, García-Moreno F, Rodriguez-Velasco G, Martínez-Botas J, Gómez-Coronado D, Escobar-Morreale HF, Botella-Carretero JI Tags: J Bone Miner Metab Source Type: research
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Source: Diabetes Metab - October 4, 2015 Category: Endocrinology Tags: Report Source Type: research
Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases.
Abstract
As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification of fat and/or fatty acid intake could have a preventive potential. The aim of the guideline of the German Nutrition Society (DGE) was to systematically evaluate the evidence for the prevention of the widespread diseases obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease (CHD), stroke, and cancer through the intake of fat or fatty acids. The ...
Source: Diabetes Metab - October 1, 2015 Category: Endocrinology Authors: Wolfram G, Bechthold A, Boeing H, Ellinger S, Hauner H, Kroke A, Leschik-Bonnet E, Linseisen J, Lorkowski S, Schulze M, Stehle P, Dinter J Tags: Ann Nutr Metab Source Type: research
Erratum to: Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18-65 years old) who are overfat, or obese; systematic review and meta-analysis.
Abstract
[This corrects the article DOI: 10.1186/s40200-015-0154-1.].
PMID: 26417564 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - October 1, 2015 Category: Endocrinology Authors: Clark JE Tags: J Diabetes Metab Disord Source Type: research
Insulin-Mediated Diseases: Adrenal Mass and Polycystic Ovary Syndrome.
Abstract
Adrenal incidentalomas (AIs) and polycystic ovary syndrome (PCOS) have often been associated with compensatory hyperinsulinemia and insulin resistance (IR). The link between these diseases and IR may be changes in hormone secretions that provoke IR and in turn promote the growth of adrenal gland masses and/or ovarian cysts through compensatory hyperinsulinemia.
PMID: 26412152 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - October 1, 2015 Category: Endocrinology Authors: Muscogiuri G, Colao A, Orio F Tags: Trends Endocrinol Metab Source Type: research
Visceral Adipose Tissue Mesothelial Cells: Living on the Edge or Just Taking Up Space?
Abstract
Visceral adiposity and pathological adipose tissue remodeling, a result of overnutrition, are strong predictors of metabolic health in obesity. Factors intrinsic to visceral adipose depots are likely to play a causal role in eliciting the detrimental effects of this tissue on systemic nutrient homeostasis. The visceral adipose-associated mesothelium, a monolayer of epithelial cells of mesodermal origin that line the visceral serosa, has recently attracted attention for its role in metabolic dysfunction. Here we highlight and consolidate literature from various fields of study that points to the vi...
Source: Diabetes Metab - October 1, 2015 Category: Endocrinology Authors: Gupta OT, Gupta RK Tags: Trends Endocrinol Metab Source Type: research
