Positive correlation of plasma PCSK9 levels with HbA1c in type-2 diabetic patients.
CONCLUSIONS: Data firstly suggested a positive correlation of PCSK9 levels with HbA1c in T2DM patients but not in non-T2DM patients, indicating a potential role of PCSK9 in type-2 diabetes. This article is protected by copyright. All rights reserved.
PMID: 26377225 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 17, 2015 Category: Endocrinology Authors: Yang SH, Li S, Zhang Y, Xu RX, Guo YL, Zhu CG, Wu NQ, Cui CJ, Sun J, Li JJ Tags: Diabetes Metab Res Rev Source Type: research
Inadequate hepcidin serum concentrations predict incident type 2 diabetes mellitus.
CONCLUSIONS: Hepcidin levels that are inadequately low in relation to body iron stores are an independent predictor for incident T2DM and may contribute to diabetes-related tissue iron overload. This article is protected by copyright. All rights reserved.
PMID: 26378394 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 17, 2015 Category: Endocrinology Authors: Pechlaner R, Weiss G, Bansal S, Mayr M, Santer P, Pallhuber B, Notdurfter M, Bonora E, Willeit J, Kiechl S Tags: Diabetes Metab Res Rev Source Type: research
Phenotypic characterization of insulin-resistant and insulin-sensitive obesity.
CONCLUSIONS: Obese subjects who were insulin-sensitive at muscle and/or liver exhibited favorable metabolic features, including lower BP, liver and visceral adiposity. This study identifies factors associated with, and possibly contributing to, insulin sensitivity in obesity.
PMID: 26378474 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 17, 2015 Category: Endocrinology Authors: Chen DL, Liess C, Poljak A, Xu A, Zhang J, Thoma C, Trenell M, Milner B, Jenkins AB, Chisholm DJ, Samocha-Bonet D, Greenfield JR Tags: J Clin Endocrinol Metab Source Type: research
Essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions.
CONCLUSIONS: EPL could be a potent agent to protect islets from inflammatory and hypoxic conditions after isolation procedures. Further studies to clarify the effect of EPL in islet transplantation are warranted. This article is protected by copyright. All rights reserved.
PMID: 26378630 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 17, 2015 Category: Endocrinology Authors: Shahbazov R, Kanak MA, Takita M, Kunnathodi F, Khan O, Borenstein N, Lawrence MC, Levy MF, Naziruddin B Tags: Diabetes Metab Res Rev Source Type: research
Role of Endocannabinoids in the progression of diabetic retinopathy.
This article is protected by copyright. All rights reserved.
PMID: 26379208 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 17, 2015 Category: Endocrinology Authors: Behl T, Kaur I, Kotwani A Tags: Diabetes Metab Res Rev Source Type: research
Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management.
This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.
PMID: 26366100 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 16, 2015 Category: Endocrinology Authors: Palimeri S, Palioura E, Diamanti-Kandarakis E Tags: Diabetes Metab Syndr Obes Source Type: research
Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice.
CONCLUSIONS: This study proposes that combining probiotics and/or prebiotics with antidiabetic drugs improves glycemic control and insulin sensitivity in mice. Mechanisms could be related to incretin secretion.
PMID: 26366205 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 16, 2015 Category: Endocrinology Authors: Stenman LK, Waget A, Garret C, Briand F, Burcelin R, Sulpice T, Lahtinen S Tags: Diabetol Metab Syndr Source Type: research
Efficacy and tolerability of vildagliptin as first line treatment in patients with diabetes type 2 in an outpatient setting.
CONCLUSIONS: Vildagliptin is well tolerated either as monotherapy or in combination but the majority of patients require add-on therapy shortly after the beginning of treatment.
PMID: 26355765 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 14, 2015 Category: Endocrinology Authors: Yavropoulou MP, Pikilidou M, Kotsa K, Michopoulos A, Papakonstantinou E, Yovos JG Tags: J Diabetes Metab Disord Source Type: research
Evaluation of the relationship between the pelvic floor muscles and insulin resistance.
CONCLUSION: Compared with the control group, the IR group showed lower electromyographic activity of the PFMs, and there was an association between insulin levels and electromyographic activity.
PMID: 26357485 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 14, 2015 Category: Endocrinology Authors: Micussi MT, Freitas RP, Angelo PH, Soares EM, Lemos TM, Maranhão TM Tags: Diabetes Metab Syndr Obes Source Type: research
Achieving the Composite Endpoint of HbA1c
CONCLUSIONS: Dulaglutide is an effective treatment option, resulting in a similar or greater proportion of patients who reached the HbA1c target of <7.0% (53 mmol/mol), without weight gain or hypoglycaemia compared to active comparators.
PMID: 26362460 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - September 12, 2015 Category: Endocrinology Authors: Dungan KM, Raz I, Skrivanek Z, Sealls W, Fahrbach JL Tags: Diabetes Obes Metab Source Type: research
Effects of dextromethorphan as add-on to sitagliptin on blood glucose and serum insulin concentrations in individuals with type 2 diabetes mellitus: A randomized, placebo-controlled, double-blinded, multiple crossover, single-dose clinical trial.
Abstract
In this clinical trial, we investigated the BG-lowering effects of 30, 60 and 90 mg DXM as well as 100 mg sitagliptin (Sita) alone versus combinations of DXM and Sita during an oral glucose tolerance test (OGTT) in 20 male individuals with T2DM. The combination of 60 mg DXM plus 100 mg Sita showed the strongest effect in the OGTT. It lowered maximum BG concentrations and increased baseline-adjusted area under the curve of serum insulin concentrations in the first 30 minutes of the OGTT (Mean±SD: 240 ± 47 mg/dl and 8.1 ± 6.1 mU/l/h, respectively) to a significantly larger exten...
Source: Diabetes Metab - September 12, 2015 Category: Endocrinology Authors: Marquard J, Stirban A, Schliess F, Sievers F, Welters A, Otter S, Fischer A, Wnendt S, Meissner T, Heise T, Lammert E Tags: Diabetes Obes Metab Source Type: research
Immunization of AGE-modified albumin inhibits diabetic nephropathy progression in diabetic mice.
CONCLUSION: AGE-BSA and AGE-BSA-KLH immunizations inhibit the progression of DN. Our results strengthen the evidence that the anti-AGE antibodies have a protective role against diabetic vascular complication, especially DN. This study provides a basis for the development of DN-based immunotherapy with AGE immunization as a potential candidate.
PMID: 26346342 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 11, 2015 Category: Endocrinology Authors: Mashitah MW, Azizah N, Samsu N, Indra MR, Bilal M, Yunisa MV, Arisanti AD Tags: Diabetes Metab Syndr Obes Source Type: research
Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice.
Abstract
The kallikrein-kinin system is well known for its role in pain and inflammation, and has been shown recently by our group to have a role also in the regulation of energy expenditure. We have demonstrated that B1 receptor knockout (B1KO) mice are resistant to obesity induced by a high-fat diet (HFD) and that B1 receptor expression in adipocytes regulates glucose tolerance and predisposition to obesity. However, it is also known that in the absence of B1 receptor, the B2 receptor is overexpressed and can take over the function of its B1 counterpart, rendering uncertain the role of each kinin recepto...
Source: Diabetes Metab - September 11, 2015 Category: Endocrinology Authors: Morais RL, Silva ED, Sales VM, Filippelli-Silva R, Mori MA, Bader M, Pesquero JB Tags: Diabetes Metab Syndr Obes Source Type: research
Metabolic abnormalities in pituitary adenoma patients: a novel therapeutic target and prognostic factor.
Abstract
Metabolic abnormalities are common in cancers, and targeting metabolism is emerging as a novel therapeutic approach to cancer management. Pituitary adenoma (PA) is a type of benign tumor. Impairment of tumor cells' metabolism in PA seems not to be as apparent as that of other malignant tumor cells; however, aberrant hormone secretion is conspicuous in most PAs. Hormones have direct impacts on systemic metabolism, which in turn, may affect the progression of PA. Nowadays, conventional therapeutic strategies for PA do not include modalities of adjusting whole-body metabolism, which is most likely du...
Source: Diabetes Metab - September 11, 2015 Category: Endocrinology Authors: Zheng X, Li S, Zhang WH, Yang H Tags: Diabetes Metab Syndr Obes Source Type: research
Assessing cardiometabolic risk in middle-aged adults using body mass index and waist-height ratio: are two indices better than one? A cross-sectional study.
CONCLUSIONS: These data provide evidence that the use of BMI and WHtR together may improve body fat classification. Risk stratification using a composite index may provide a more accurate method for identifying high and low-risk subjects.
PMID: 26351521 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - September 11, 2015 Category: Endocrinology Authors: Millar SR, Perry IJ, Phillips CM Tags: Diabetol Metab Syndr Source Type: research
