Immunization of AGE-modified albumin inhibits diabetic nephropathy progression in diabetic mice.
CONCLUSION: AGE-BSA and AGE-BSA-KLH immunizations inhibit the progression of DN. Our results strengthen the evidence that the anti-AGE antibodies have a protective role against diabetic vascular complication, especially DN. This study provides a basis for the development of DN-based immunotherapy with AGE immunization as a potential candidate.
PMID: 26346342 [PubMed]
Source: Diabetes Metab - Category: Endocrinology Authors: Mashitah MW, Azizah N, Samsu N, Indra MR, Bilal M, Yunisa MV, Arisanti AD Tags: Diabetes Metab Syndr Obes Source Type: research
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