Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Hemodynamics and cardiac autonomic modulation after an acute concurrent exercise circuit in older individuals with pre- to established hypertension
CONCLUSION: CEX induced PEH in the older individuals with prehypertension status. At least in the first 50 min, PEH occurred parallel to the decreased Q a nd increased HR, while SVR was not different. The changes in autonomic outflow appeared to be unrelated to the acute cardiac and hemodynamic responses. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Effects of sympathectomy on myocardium remodeling and function
CONCLUSION: These findings suggest that an extra cardiac compensatory pathway increases the sympathetic tonus and maintains a higher HR and higher levels of peripheral catecholamines in the procedure groups. The increase in HF activity can be interpreted as an attempt to increase the parasympathetic tonus to balance the greater sympathetic activity. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Clinical Efficacy of Controlled-Release Morphine Tablets Combined with Celecoxib in Pain Management and the Effects on WNK1 Expression
CONCLUSION: Combination treatment with controlled-release morphine tablets and celecoxib can be extensively used in the clinical setting because it effectively improves the symptoms, QOL score, and adverse effects in patients with osteocarcinoma-related pain. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Obesity as an additional factor for autonomic imbalance and poor sleep behavior in chronic obstructive pulmonary disease: a case-control study
CONCLUSION: Overweight COPD patients showed lower autonomic modulation and impaired sleep quality, latency, and efficiency as compared eutrophic subjects. These results reinforce the importance of weight control and the acquisition of healthy habits in this population. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Symptoms of anxiety and depression and their relationship with barriers to physical activity in patients with intermittent claudication
CONCLUSION: Symptoms of anxiety and depression are prevalent among patients with peripheral arterial occlusive disease (PAD). Depression symptoms are associated with personal barriers to exercise, while anxiety symptoms are not. The main barriers to physical activity among patients with IC are exercise-induced pain and the presence of other diseases. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Association of serum chemokine ligand 21 levels with asthma control in adults
CONCLUSIONS: Serum CCL21 levels may be a new biomarker for assessing asthma control. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Scarce Resource Allocation for Critically ill Patients During the COVID-19 Pandemic: A Public Health Emergency in São Paulo Brazil
(Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Sensitivity and specificity in prevalence studies: The importance of considering uncertainty
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SA...
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Proposed recommendations for antithrombotic prophylaxis for children and adolescents with severe infection and/or multisystem inflammatory syndrome caused by SARS-CoV-2
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SA...
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil
CONCLUSION: In this study, the HER2 rs1136201 polymorphism did not show any statistically significant association with breast cancer, both in premenopausal and postmenopausal women. Nevertheless, further studies with a larger sample size should be performed to assess the association of HER2 polymorphism with breast cancer risk in women from the Northeastern region of Brazil. (Source: Clinics)
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Natural versus Recombinant Viral Antigens in SARS-CoV-2 Serology: Challenges in Optimizing Laboratory Diagnosis of COVID-19
CONCLUSION: The choice of antigen is an important aspect in optimizing the laboratory diagnosis of COVID-19. The use of rNP ELISA for the detection of anti-SARS-CoV-2 IgG antibodies seems promising, but comparison of the results with those of WVA ELISA is crucial for accurate test development prior to commercialization. IgG serology using several assays, and with the spectral patterns of SARS-CoV-2, resulted in confusing information that must be clarified before the establishment of diagnostic serology criteria. (Source: Clinics)
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Differences in Total Brain Volume between Sexes in a Cognitively Unimpaired Elderly Population
CONCLUSION: After the ICV correction and taking into account differences in socioeconomic status and years of schooling, our results confirm previous findings of proportionally larger GM in women, as well as larger WM volumes. These results in an elderly population indicate that brain volumetric differences between sexes persist throughout the aging process. Additional studies combining MRI and other biomarkers to identify the hormonal and molecular bases influencing such differences are warranted. (Source: Clinics)
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Validity Evidences of the Prefrontal Symptoms Inventory for the Elderly Brazilian Population
CONCLUSION: The results of this study indicate that the PSI-16 can be used as a valid and reliable screening tool for clinical use in the elderly with and without pathology. (Source: Clinics)
Source: Clinics - December 9, 2020 Category: General Medicine Source Type: research
Early COVID-19 infection after lung transplantation in a patient with cystic fibrosis
Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SA...
Source: Clinics - December 1, 2020 Category: General Medicine Source Type: research
