Association between ventilatory settings and pneumothorax in extremely preterm neonates
CONCLUSIONS: Pressure-related ventilatory settings in mechanically ventilated extremely low birth weight neonates are not associated with a higher risk of pneumothorax in the first 7 days of life. (Source: Clinics)
Source: Clinics - March 24, 2021 Category: General Medicine Source Type: research
Acoustically Controlled Binaural Auditory Training with Vocal Duets: Assessment and Effectiveness
CONCLUSION: The effectiveness of ATVD was evidenced, and the results were maintained after 3 months. (Source: Clinics)
Source: Clinics - March 24, 2021 Category: General Medicine Source Type: research
Safety and effectiveness of mycophenolate mofetil associated with tacrolimus for liver transplantation immunosuppression: a systematic review and meta-analysis of randomized controlled trials
A combination of immunosuppressants may improve outcomes due to the synergistic effect of their different action mechanisms. Currently, there is no consensus regarding the best immunosuppressive protocol after liver transplantation. This review aimed to evaluate the effectiveness and safety of tacrolimus associated with mycophenolate mofetil (MMF) in patients undergoing liver transplantation. We performed a systematic review and meta-analysis of randomized clinical trials. Eight randomized trials were included. The proportion of patients with at least one adverse event related to the immunosuppression scheme with tacrolimu...
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
miR-139-5p protects septic mice with acute lung injury by inhibiting Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor-&mac_kgr;B signaling pathway
CONCLUSION: miR-139-5p inhibits the TLR4/MyD88/NF- κ B signaling pathway to alleviate acute lung injury in septic mice. (Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Signs of impending rupture in abdominal aortic and iliac artery aneurysms by computed tomography: Outcomes in 41 patients
CONCLUSIONS: The presence of focal wall discontinuity of circumferential calcifications was the most common SIR. There was a prevalence of all signs in less than 5% of asymptomatic patients. In unrepaired patients, the signs could be observed on follow-up CT scans with an increase in aneurysm size, indicating that the presence of SIR alone in the absence of other clinical factors or aneurysm characteristics is an insufficient indication for surgery. (Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Azeliragon ameliorates Alzheimer's disease via the Janus tyrosine kinase and signal transducer and activator of transcription signaling pathway
CONCLUSIONS: TTP488 administration successfully reduced AD injury and reversed the aforementioned processes. Additionally, tofacitinib and fludarabine administration could further reverse AD injury after the TTP488 intervention. These results suggest a new potential mechanism underlying the TTP488-mediated alleviation of AD injury. (Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Endoscopy infection control strategy during the COVID-19 pandemic: experience from a tertiary cancer center in Brazil
CONCLUSIONS: In this pandemic scenario, all endoscopy services must prioritize the procedures that will be performed. It was possible to maintain some endoscopic procedures, including those meant to provide nutritional access, tissue diagnosis, and endoscopic resection. Person al protective equipment (PPE) seems effective in preventing transmission of COVID-19 from patients to digestive endoscopists. These measures can be useful in planning, even for pandemics in the future. (Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Acellular dermal matrix in skin wound healing in rabbits - histological and histomorphometric analyses
CONCLUSION: The use of acellular dermal matrix increased the thickness of the dermal and epidermal layers and the amount of type I and III collagen during skin wound healing and did not alter the rate of wound contraction. (Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Reopening borders: protocols for resuming travel during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Decreased Glasgow Coma Scale score in medical patients as an indicator for intubation in the Emergency Department: Why are we doing it?
(Source: Clinics)
Source: Clinics - March 8, 2021 Category: General Medicine Source Type: research
Fatty Pancreas: Disease or Finding?
Despite a growing number of investigative studies on pancreatic fat deposition, there remains no clear indication regarding the clinical relevance of fat infiltration in the pancreas, also called fatty pancreas (FP). An individual ’ s body weight is correlated with their pancreatic weight. Moreover, lipid infiltration causes disorders that compromise not only morphology but also metabolic functions. Fat infiltration leads to insulin resistance, type II diabetes mellitus, and pancreatic cancer; however, knowledge about pancreatic fat content and aspects related to the clinical profile remains unclear in the literature. Th...
Source: Clinics - February 23, 2021 Category: General Medicine Source Type: research
Arterial stiffness in type 2 diabetes: determinants and indication of a discriminative value
CONCLUSIONS: In T2DM, an indicator of the discriminative value of arterial stiffness was cfPWV of 7.9 m/s. Clinical findings and comorbidities, such as hypertension, glucose, poor glycemic control, and dyslipidemia, were associated with and were determinants of arterial stiffness in T2DM. Reinforcement of monitoring risk factors, such as hypertension, dyslipidemia, and glycemic control, seems to be essential to the process of arterial stiffening. Confirmation of this discriminative value in larger populations is recommended. (Source: Clinics)
Source: Clinics - February 23, 2021 Category: General Medicine Source Type: research
In vitro anti-inflammatory effects of vitamin D supplementation may be blurred in hemodialysis patients
CONCLUSIONS: Thus, cholecalciferol supplementation is an efficient strategy to ameliorate hypovitaminosis D in hemodialysis patients, but its beneficial effects on the control of secondary hyperparathyroidism are relatively unclear. Even though cholecalciferol exhibited anti-inflammatory effects in vitro, its short-term supplementation was not effective in improving the inflammatory profile of patients on hemodialysis, as indicated by the IL-1 β and hs-CRP levels. (Source: Clinics)
Source: Clinics - February 23, 2021 Category: General Medicine Source Type: research
Information technology challenges in a public hospital during the COVID-19 pandemic
(Source: Clinics)
Source: Clinics - February 23, 2021 Category: General Medicine Source Type: research
Erratum for: Management of Hepatocellular Carcinoma during the COVID-19 Pandemic – São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement
In this study, we aimed to evaluate the impact of PVT in LT outcomes and analyze the types of surgical techniques used for dealing with PVT during LT. A systematic review was conducted in Cochrane, MEDLINE, and EMBASE databases, selecting articles from January 1990 to December 2019. The MESH-terms used were ( “ Portal Vein ” [Mesh] AND “ Thrombosis ” [Mesh] NOT “ Neoplasms ” [Mesh]) AND ( “ Liver Transplantation ” [Mesh]). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) recommendation was used, and meta-analysis was performed with Review Manager Version 5.3 software. A total ...
Source: Clinics - February 5, 2021 Category: General Medicine Source Type: research
