Extracellular matrix metalloproteinase expression in endometrial tissue after arterial embolization of myomas
CONCLUSIONS: The results suggest that ECM continues to undergo tissue remodeling 6 months after AEM, at least with regard to MMP3 expression, suggesting that AEM affects the ECM for at least 6 months after the procedure. (Source: Clinics)
Source: Clinics - January 22, 2021 Category: General Medicine Source Type: research
Maternal hypothyroidism during pregnancy alters the function of the retinol-binding protein 4-mediated mitochondrial permeability conversion pore in the kidneys of offspring rats
CONCLUSION RBP4 plays an important role in early renal mitochondrial damage and renal impairment in rats suffering from hypothyroidism during pregnancy. The RBP4/PiC/SIRT3 pathway is thus involved in the opening of the renal mPTP in offspring rats with hyperthyroidism. (Source: Clinics)
Source: Clinics - January 22, 2021 Category: General Medicine Source Type: research
Performance of mutation pathogenicity prediction tools on missense variants associated with 46,XY differences of sex development
CONCLUSION: Computational algorithms are important tools for SNV analysis, but their correlation with functional studies not consistent. In the present analysis, the best performing tools (based on accuracy, precision, and specificity) were Mutation Assessor, MutPred, and SNPs&GO, which presented the best concordance with functional studies. (Source: Clinics)
Source: Clinics - January 22, 2021 Category: General Medicine Source Type: research
Cognitive performance and long-latency auditory evoked potentials: a study on aging
CONCLUSION: There is a relationship between long-latency potentials and cognitive performance in the elderly, which was observed by the increase in the P2 amplitude and the impairment of the process of sound decoding. (Source: Clinics)
Source: Clinics - January 22, 2021 Category: General Medicine Source Type: research
Ultrasound-guided peripheral abdominal wall blocks
The practice of regional anesthesia is in a state of progressive evolution, mainly due to the advent of ultrasound as an anesthesiologist's instrument. Alternative techniques for postoperative analgesia of abdominal surgeries, such as transversus abdominis plane block, oblique subcostal transversus abdominis plane block, rectus abdominis muscle sheath block, ilioinguinal and iliohypogastric nerve block, and quadratus lumborum plane block, have proven useful, with good analgesic efficacy, especially when neuroaxial techniques (spinal anesthesia or epidural anesthesia) are not possible. This review discusses such blockades i...
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Previous preeclampsia and its association with the future development of cardiovascular diseases: a systematic review and meta-analysis
Preeclampsia is a multifactorial disease. Among these factors, untreated hypertension during pregnancy can result in high morbidity and mortality rates and may also be related to the future development of cardiovascular diseases.Therefore, this systematic review aimed to determine the association of previous preeclampsia with the future development of cardiovascular diseases. Studies on the association between preeclampsia and future cardiovascular diseases published in the last 10 years (2009-2019) were identified from the PubMed/Medline (207 articles), Embase (nine articles), and Cochrane (three articles) databases using...
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Trends in abdominal aortic aneurysm-related mortality in Brazil, 2000-2016: a multiple-cause-of-death study
CONCLUSIONS: This study highlights the need to accurately document epidemiologic trends related to AAA in Brazil. We demonstrate the burden of AAA on mortality in older individuals, and our results may assist with effective planning of mortality prevention and control in patients with AAA. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Effects of Raloxifene Combined with Low-dose Conjugated Estrogen on the Endometrium in Menopausal Women at High Risk for Breast Cancer
CONCLUSION: Combined raloxifene and low-dose CE decreased the severity of menopausal symptoms to a similar extent as CE alone and had similar effects as raloxifene alone on the endometrium. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Predictors and reference equations for augmentation index, an arterial stiffness marker, in healthy children and adolescents
CONCLUSION: In the present study, we used a representative sample from Belo Horizonte to establish normality values of AIx@75. We also identified, for the first time, independent predictors of AIx@75 in healthy children and adolescents categorized by sex and age. Determining AIx@75 reference equations may facilitate the early diagnosis of preclinical atherosclerosis and allow an objective measure of the vascular effects of therapeutic interventions aimed at modifying cardiovascular risk factors. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study
CONCLUSION: This preliminary study observed pathogenic mutations in US and UCS samples. Further studies with a larger cohort and functional analyses will foster the development of a precision medicine-based approach for the treatment of US and UCS. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Thoracic aortic size in Brazilian smokers: measures using low-dose chest computed tomography anatomical and epidemiological assessment
CONCLUSIONS: This study with low-dose CT allowed the determination of the mean diameters of the ascending aorta, aortic arch, and descending aorta in Brazilian smokers and TAA prevalence. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Exploration of the risk factors of essential hypertension with hyperhomocysteinemia: A hospital-based study and nomogram analysis
CONCLUSIONS: Men are more likely to have H-type hypertension, and advanced age, high BMI, high total cholesterol levels, and high glucose levels are risk factors of H-type hypertension in healthy and hyperhomocysteinemia populations. Furthermore, high creatinine level is a risk factor of H-type hypertension in healthy and hypertension populations. Nomogram models may be used to intuitively evaluate H-type hypertension risk and provide a basis for personalized interventions. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
miRNA-195 expression in the tumor tissues of female Brazilian breast cancer patients with operable disease
CONCLUSION: miRNA-195 is downregulated in the tumor tissues of Brazilian breast cancer patients regardless of NAC exposure; this reinforces its role as a tumor suppressor and a potential biomarker for chemotherapy response. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Comparison of Different Ultrasound Classification Systems of Thyroid Nodules for Identifying Malignant Potential: A Cross-sectional Study
CONCLUSION: The ACR TIRADS classification system is less invasive and can identify suspicious nodules more accurately than that of ATA and AACE/ACE/AME. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
Radiotherapy for early and advanced stages Follicular Lymphoma
CONCLUSION FL is an indolent disease. Our findings show good outcomes for patients treated with radiation, with a low transformation rate and excellent management of relapsed disease. RT is an important part of these results. (Source: Clinics)
Source: Clinics - January 21, 2021 Category: General Medicine Source Type: research
