Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Roles of integrin in tumor development and the target inhibitors
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Zhao-He LI, You ZHOU, You-Xiang DING, Qing-Long GUO, Li ZHAOAbstractIntegrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell ...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Wei WANG, Qing-Bin LIU, Wei JINGAbstractAstragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two combination group (control group, the combination of budesonide and terbutaline) and A. membranaceus group (treatment group, the combination of budesonide, terbutaline and A. membranaceus). The therapeutic results were compared between two groups afte...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells
This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromocytoma (PC12) cells. Our results demonstrate that ATL-III increases cell viability and reduces the release of lactate dehydrogenase (LDH). The results suggest that ATL-III protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca2+ overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF-ΚB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-III protected the PC12 cells agains...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

A novel approach based on metabolomics coupled with network pharmacology to explain the effect mechanisms of Danggui Buxue Tang in anaemia
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Yong-Li HUA, Qi MA, Zi-Wen YUAN, Xiao-Song ZHANG, Wan-Ling YAO, Peng JI, Jun-Jie HU, Yan-Ming WEIAbstractDanggui Buxue Tang (DBT) is a famous Chinese medicinal decoction. Mechanism of DBT action is wide ranging and unclear. Exploring new ways of treatment with DBT is useful. Sprague-Dawley(SD) rats were randomly divided into 3 groups including control (NC, Saline), the DBT (at a dose of 8.10 g−1), and blood deficiency(BD) (Cyclophosphamide (APH)-andCyclophosphamide(CTX)-induced anaemia). A metabolomics approach using Li...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Cheng-Yao MA, Jia-Hui LU, Xiang LI, Xiao LIU, Jian-Wei CHENAbstractEight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity. (Source: Chinese Journa...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Lin CHEN, Jia-Luo HUANG, Lei ZHANG, Hai-Yan TIAN, Sheng YINAbstractJatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2–9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhi...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

New octadecanoid derivatives from the seeds of Ipomoea nil
Publication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Xiu-Qing SONG, Jun-Sheng ZHANG, Shu-Juan YU, Jin-Hai YU, Hua ZHANGAbstractFour new octadecanoid derivatives (1–4) including a pair of enantiomers (1/2), along with 12 known analogues (5–16), were isolatedfrom the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not sh...
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Rapid discovery and identification of the anti-inflammatory constituents in Zhi-Shi-Zhi-Zi-Chi-Tang
In conclusion, the predicted results indicated that the activity index method is feasible for the accurate prediction of active constituents in TCM formulae. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 8, 2019 Category: Complementary Medicine Source Type: research

Non-volatile constituents and pharmacology of Chimonanthus: A review
Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Ren-Geng SHU, Yi-Li WAN, Xiao-Min WANGAbstractChimonanthus plants widely distributed in southern area of China, which have a long history of edibles and medicine. Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents, including alkaloids, flavonoids, terpenoids, coumarins and others, which exhibit significant anti-oxidant, anti-bacterial, anti-cancer, anti-inflammatory, antihyperglycemic, antihyperlipidemic and other biological activities. On the basis of systematic reviewing of ...
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice
This study proved the high-value application of HCP. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1
Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Meng-Yao SUN, Dan-Dan WANG, Jian SUN, Xiao-Hua ZHAO, Si CAI, Qiu-Xue WU, Tao JIE, Zhen-Hua NI, Jian-Yue SUN, Qing-Feng TANGAbstractResistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still ...
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

Two natural molecules preferentially inhibit azole-resistant Candida albicans with MDR1 hyperactivation
In this study, we established a co-culture assay in which an azole-resistant Candida albicans strain was mixed with a susceptible strain labeled with green fluorescent protein to mimic in vivo conditions and screen for antifungal drugs. Fluconazole was used as a positive control to verify the validity of this co-culture assay. Five natural molecules exhibited antifungal activity against both susceptible and resistant C. albicans. Two of these compounds, retigeric acid B (RAB) and riccardin D (RD), preferentially inhibited C. albicans strains in which the efflux pump MDR1 was activated. This selectivity was attributed to gr...
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis
This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patie...
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

Two new nimbolinin- and trichilin-class limonoids isolated from the fruits of Melia azedarach
Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Lu QIU, Li HENG, Rong XU, Jun LUO, Yi LIAbstractTwo new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 μmol·L−1. (Source: Chinese Jou...
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research

Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS
In conclusion, gut microbiota plays an important role in biotransformation of PNS into metabolites in vivo. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 23, 2019 Category: Complementary Medicine Source Type: research