Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Danshen: a phytochemical and pharmacological overview
This article intends to provide novel insight information for further development of Danshen, which could be of great value to its improvement of utilization. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research

Advanced natural products chemistry research in China between 2015 and 2017
Publication date: December 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 12Author(s): Guo-Xun YANG, Guang-Lei MA, Hao LI, Ting HUANG, Juan XIONG, Jin-Feng HUAbstractIn this review, we intensively focus on the advances in research of natural products (NPs) discovery carried out by domestic scholars in China from 2015 through 2017. In general, a total of 1811 publications (1479 in English and 332 in Chinese) were accumulated regarding newly isolated NPs from plants, microorganisms, and marine sources. As a result, 277 selected papers concerning naturally occurring compounds with extraordinary frameworks,...
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

Carnosic acid enhances the anti-lung cancer effect of cisplatin by inhibiting myeloid-derived suppressor cells
In conclusion, our study proved that the functional suppression of MDSC by carnosic acid promoted the lethality of CD8+ T cells, which contributed to the enhancement of anti-lung cancer effect of cisplatin. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling
In conclusion, zebrafish behavior profiling could be used as a high-throughput platform to screen neuroactive effects and predict molecular pathways of extracts and components from TCM. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

Anti-rheumatoid arthritic effect of volatile components in notopterygium incisum in rats via anti-inflammatory and anti-angiogenic activities
Publication date: December 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 12Author(s): Jian-Ping BI, PING LI, Xi-Xi XU, Ting WANG, Fei LIAbstractNotopterygium incisum (QH) has been used for the treatment of rheumatoid arthritis (RA), and volatile oils may be its mainly bioactive constituents. The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic capacity of Notopterygium volatile oils and the potential mechanism of action. The volatile compounds analysis was conducted by GC-MS. The anti-arthritic capacity test of the volatile oils was conducted on adj...
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

Regulatory effects of Poria on substance and energy metabolism in cold-deficiency syndrome compared with heat-deficiency syndrome in rats
Publication date: December 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 12Author(s): Xue-Ying HAN, Ya-Nan WANG, De-Qiang DOUAbstractRecent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling (FL) in traditional Chinese medicine (TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi (FZ) in TCM, with hot property, and Anem...
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

New limonoids isolated from the bark of Melia toosendan
Publication date: December 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 12Author(s): Qiong ZHANG, Qing-Hong ZHENG, Yi-Shu SANG, Herman Ho-Yung SUNG, Zhi-Da MINAbstractTwo new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1–3 were evaluated for their cytotoxicity against five tumor cell li...
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

Flavonoids rather than alkaloids as the diagnostic constituents to distinguish Sophorae Flavescentis Radix from Sophorae Tonkinensis Radix et Rhizoma: an HPLC fingerprint study
Publication date: December 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 12Author(s): Pei-Lan DING, Chang-Ming HE, Zhi-Hong CHENG, Dao-Feng CHENAbstractSophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applications. In order to find out the characteristic chemical constituents potentially leading to the unique medicinal properties claimed for each...
Source: Chinese Journal of Natural Medicines - December 28, 2018 Category: Complementary Medicine Source Type: research

The CXCL12 (SDF-1)/CXCR4 chemokine axis: Oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy
In conclusion, the CXCL12/CXCR4 signaling is important for tumor development and targeting the pathway might represent an effective approach to developing novel therapy in cancer treatment. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

Phytochemistry and pharmacology of genus Ephedra
Publication date: November 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 11Author(s): Ben-Mei ZHANG, Zhi-Bin WANG, Ping XIN, Qiu-Hong WANG, He BU, Hai-Xue KUANGAbstractThe genus Ephedra of the Ephedraceae family contains more than 60 species of nonflowering seed plants distributed throughout Asia, America, Europe, and North Africa. These Ephedra species have medicinal, ecological, and economic value. This review aims to summarize the chemical constituents and pharmacological activities of the Ephedra species to unveil opportunities for future research. Comprehensive information on the Ephedra species w...
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

The metabolism and hepatotoxicity of ginkgolic acid (17 : 1) in vitro
Publication date: November 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 11Author(s): Qing-Qing YAO, Li LI, Ming-Cheng XU, Hai-Hong HU, Hui ZHOU, Lu-Shan YU, Su ZENGAbstractPharmacological activities and adverse side effects of ginkgolic acids (GAs), major components in extracts from the leaves and seed coats of Ginkgo biloba L, have been intensively studied. However, there are few reports on their hepatotoxicity. In the present study, the metabolism and hepatotoxicity of GA (17 : 1), one of the most abundant components of GAs, were investigated. Kinetic analysis indicated that human and rat liver micr...
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling
In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis
Publication date: November 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 11Author(s): Zheng-Jie MENG, Chao WANG, Ling-Tong MENG, Bei-Hua BAO, Jin-Hui WU, Yi-Qiao HUAbstractCardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysf...
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages
Publication date: November 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 11Author(s): Pérez-Gutiérrez ROSA MARTHA, Enriquez-Alvirde SUSANA GABRIELAAbstractThe present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products (AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12- en-28-oic acid (1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic...
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research

Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum
Publication date: November 2018Source: Chinese Journal of Natural Medicines, Volume 16, Issue 11Author(s): Yan SHU, Tian-Peng YIN, Jia-Peng WANG, Dong GAN, Qin-Yan ZHANG, Le CAI, Zhong-Tao DINGAbstractIn the present study, three new aconitine-type diterpenoid alkaloids brochyponines A–C (1–3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl3 were also measured. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - November 29, 2018 Category: Complementary Medicine Source Type: research