Chinese Journal of Natural Medicines 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Progress in active compounds effective on ulcerative colitis from Chinese medicines
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Si-Yu CAO, Sheng-Jie YE, Wei-Wei WANG, Bing WANG, Tong ZHANG, Yi-Qiong PUAbstractUlcerative colitis (UC), a chronic inflammatory disease affecting the colon, has a rising incidence worldwide. The known pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Nowadays, the drugs for UC include 5-aminosalicylic acid, steroids, and immunosuppressants. Long-term use of these drugs, however, may cause several side effects, such ...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Xiao-Rui CHENG, Chun-Hui QI, Tong-Xing WANG, Wen-Xia ZHOU, Yong-Xiang ZHANGAbstractLiu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature revi...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Ling-Na KONG, Xiang LIN, Cheng HUANG, Tao-Tao MA, Xiao-Ming MENG, Chao-Jie HU, Qian-Qian WANG, Yan-Hui LIU, Qing-Ping SHI, Jun LIAbstractMacrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as macrophage polarization, of which play an important role in the pathogenesis of many diseases. Numerous studies have proved that Hesperidin (HDN), a traditional Chinese ...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones
This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Two symmetrical unsaturated acids isolated from Viscum album
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Duo CAO, Li-Qing WANG, Xiao-Min HAN, Hui-Rui GUAN, Meng LEI, Ya-Hui WEI, Liang CHENG, Pei-Ming YANG, Zheng-Liang SUN, Wen GAO, Jia-Kun DAIAbstractIn the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 – 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activit...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Xiao-Wei LUO, Yun LIN, Yong-Jun LU, Xue-Feng ZHOU, Yong-Hong LIUAbstractTwo new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3–17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circ...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Romipeptides A and B, two new romidepsin derivatives isolated from Chromobacterium violaceum No.968 and their antitumor activities in vitro
Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Lei XIONG, Chang-Fa CHEN, Tao-Ling MIN, Hai-Feng HUAbstractRomipeptides A and B (1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A (3), romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis. Compounds 1–5 were eva...
Source: Chinese Journal of Natural Medicines - February 21, 2019 Category: Complementary Medicine Source Type: research
Strengthen the research on the medicinal and edible substances to advance the development of the comprehensive healthcare industry of TCMs
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Hao GAO, Xin-Sheng YAO (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Shan-Shan SUN, Kai WANG, Ke MA, Li BAO, Hong-Wei LIUAbstractMetabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide (WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a (1-3)-β-D-glucan with an average Mw of 4.486 × 106 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubus chingii
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Xiang-Yu ZHANG, Wei LI, Jian WANG, Ning LI, Mao-Sheng CHENG, Kazuo KOIKEAbstractProtein tyrosine phosphatase 1B (PTP1B) has led to an intense interest in developing its inhibitors as anti-diabetes, anti-obesity and anti-cancer agents. The fruits of Rubus chingii (Chinese raspberry) were used as a kind of dietary traditional Chinese medicine. The methanolic extract of R. chingii fruits exhibited significant PTP1B inhibitory activity. Further bioactivity-guided fractionation resulted in the isolation of three PTP1B inhibi...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Peng-Cheng LIN, Lin-Lin JI, Xiang-Jian ZHONG, Jin-Jie LI, Xin WANG, Xiao-Ya SHANG, Sheng LINAbstractGuided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the ...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Yu-Dan MEI, Nan ZHANG, Wei-Yang ZHANG, Jin-Shan TANG, Hua ZHOU, Yang YU, Xin-Sheng YAOAbstractThe flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1–12), including two new ursane-type nortriterpenes, 2α, 24-dihydroxy-23-nor-ursolic acid (1) and 2α, 4α-dihydroxy-23-nor-ursolic acid (2). Their structure...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Yu WU, Wen-Jing TIAN, Shuo GAO, Zu-Jian LIAO, Guang-Hui WANG, Jir-Mehng LO, Pei-Hsin LIN, De-Quan ZENG, Da-Ren QIU, Xiang-Zhong LIU, Mi ZHOU, Ting LIN, Hai-Feng CHENAbstractAntrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphora...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Anti-cancer activities of S-allylmercaptocysteine from aged garlic
Publication date: January 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 1Author(s): Yi LV, Kwok-Fai SO, Nai-Kei WONG, Jia XIAOAbstractWhile most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer activities than that of fresh garlic, by virtue of enrichment of several AGE-s...
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease
This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - January 29, 2019 Category: Complementary Medicine Source Type: research
