Chinese Journal of Natural Medicines This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Chemical constituents and biological activities of lycophytes and ferns
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Qin-Feng ZHU, Qin-Shi ZHAOAbstractLycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and evolution. The Chinese lycophytes and ferns flora, with approximately 2000 species, contributes a substantial component to the global lycophytes and ferns diversity, with estimates of 12 000 species. Among them, about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural med...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Yi LING, Lin-Lin TENG, Juan HUA, De-Sen LI, Shi-Hong LUO, Yan-Chun LIU, Yan LIU, Sheng-Hong LIAbstractObesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated ...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Four new sesquiterpene derivatives from Dendrobium findlayanum
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Dan YANG, Zhong-Quan CHENG, Cheng-Ting ZI, Liu YANG, Fa-Wu DONG, Jiang-Miao HU, Jun ZHOUAbstractThree new sesquiterpene glycosides with alloaromadendrane and ylangene-derived type aglycones, named dendrofindlayanosides A–C (1–3), one new cyclopacamphane type sesquiterpene named dendrofindlayanobilin A (4), together with five known compounds have been isolated from stems of Dendrobium findlayanum. Their structures were determined on the basis of spectroscopic and chemical methods. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jie ZHANG, Chuan-Xi WANG, Xiao-Jun SONG, Shuang LI, Huan ZHAO, Guo-Dong CHEN, Dan HU, Hao GAO, Xin-Sheng YAOAbstractA pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrob...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Highly oxygenous trichilin-type limonoids from Trichilia sinensis
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Fa-Liang AN, Yong YIN, Jun LUO, Ling-Yi KONGAbstractSix new trichilin-type limonoids (1–6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1H NMR, 13C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (SRB)...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Four new corynanthe-type alkaloids from the roots of Alstonia scholaris
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jian ZHANG, Hua LI, Yong LI, Zi-Wei LI, Chen-Chen SANG, Mei-Hua GAO, Dong-Mei ZHANG, Xiao-Qi ZHANG, Wen-Cai YEAbstractFour new corynanthe-type alkaloids, meloslines C–F (1–4), together with four known ones (5–8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries pre...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Chemical constituents from Vernonia bockiana
This study further expands the chemical space of this underexplored species. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Yue WANG, Qing-Lan GUO, Ruo-Fei LI, Cheng-Bo XU, Cheng-Gen ZHU, Jian-Gong SHIAbstractTwo new folate-derived analogues, named uncarophyllofolic acids A (1) and B (2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey's derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Bipolarins A–H, eight new ophiobolin-type sesterterpenes with antimicrobial activity from fungus Bipolaris sp. TJ403-B1
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Meng-Ting LIU, Yan HE, Ling SHEN, Zheng-Xi HU, Yong-Hui ZHANGAbstractBipolarins A–H (1–8), eight new tetracyclic ophiobolin-type sesterterpenes featuring a rare oxaspiro[4.4]nonane moiety, were isolated from cultures of fungus Bipolaris sp. TJ403-B1. Their structures and absolute configurations were elucidated by comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, electronic circular dichroism and 13C NMR calculations. Additionally, compound 5 exhibited significant selective antimic...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Anti-HIV lignans from Justicia procumbens
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Xin-Ya XU, Dong-Ying WANG, Chuen-Fai KU, Yang ZHAO, Han CHENG, Kang-Lun LIU, Li-Jun RONG, Hong-Jie ZHANGAbstractTwenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Yuan WANG, Jing LIN, Qi WANG, Kun SHANG, De-Bing PU, Rui-Han ZHANG, Xiao-Li LI, Xiao-Chang DAI, Xing-Jie ZHANG, Wei-Lie XIAOAbstractPhytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A–F (1–6), together with seven analogues (7–13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on li...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Enantiomeric pairs of meroterpenoids from Rhododendron fastigiatum
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Guang-Hui HUANG, Chun LEI, Ke-Xin ZHU, Jing-Ya LI, Jia LI, Ai-Jun HOUAbstractFive pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum. Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC. Their structures were elucidated by spectroscopic methods, X-ray crystallographic experiments, and ECD analyses. Compounds 1a/1b, 2a/2b, 3b, 4a/4b, and 5a/5b were new meroterpenoids with different polycyclic syste...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Kun HU, Xing-Ren LI, Jian-Wei TANG, Xiao-Nian Li, Pema-Tenzin PUNOAbstractNineteen preschisanartane-type schinortriterpenoids (SNTs), among which eleven ones were previously undescribed, were isolated from two Schisandra species, S. sphaerandra and S. rubriflora. Their structures were determined using 1D and 2D NMR spectroscopic analyses, NMR data comparison, quantum chemical calculation of NMR parameters, electronic circular dichroism (ECD), X-ray single crystal diffraction, and chemical derivation. Furthermore, stru...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Cangumycins A–F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Lei WANG, Li WANG, Zhi ZHOU, Yong-Jiang WANG, Jian-Ping HUANG, Ya-Tuan MA, Yang LIU, Sheng-Xiong HUANGAbstractCangumycins A–F (1–6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Deciphering the metabolic fates of herbal constituents and the interactions of herbs with human metabolic system
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Guang-Bo GE (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 10, 2019 Category: Complementary Medicine Source Type: research