Anti-HIV lignans from Justicia procumbens

Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Xin-Ya XU, Dong-Ying WANG, Chuen-Fai KU, Yang ZHAO, Han CHENG, Kang-Lun LIU, Li-Jun RONG, Hong-Jie ZHANGAbstractTwenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5.27 μmol·L−1 and a selective index (SI) value of 2.2. The known arylnaphthalene lignan procumbenoside A (3) and diphyllin (8) demonstrated inhibitory activity against HIV-1 with IC50 values of 4.95 (SI> 6.2) and 0.38 μmol·L−1 (SI = 5.3), respectively.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research