Cangumycins A–F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces

Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Lei WANG, Li WANG, Zhi ZHOU, Yong-Jiang WANG, Jian-Ping HUANG, Ya-Tuan MA, Yang LIU, Sheng-Xiong HUANGAbstractCangumycins A–F (1–6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC50 8.1 and 2.7 μmol·L−1, respectively) against human T cell proliferation at a non-cytotoxic concentration.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research