Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang Shuai Lao Pian treated mid-adult mice
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Shu-Qing GONG, Ting-Ting YE, Mei-Xia WANG, Zhu-Ping HONG, Li LIU, Huan CHEN, Jing QIAN (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Yong-Shen REN, Yao ZHENG, Huan DUAN, Lei LEI, Xin DENG, Xin-Qiao LIU, Zhi-Nan MEI, Xu-Kun DENG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Jong-Eun Lee, Sung Sik Yoon, Jae-Wook Lee, Eun-Yi Moon (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Zhi-Jian LI, Abulizi Abudumijiti, Deng-Qiu XU, Maimaiti Youlidouzi, Aibai Silafu, Zhen-Zhou JIANG, Guo-Lin ZHAO, Tao WANG, Refukati Aiximujiang, Maimaiti Zulikaer, Simayi Yiliyaer, Chun-Yu CAO, Lu-Yong ZHANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Tao-Guang HUO, Ying FANG, Ying-Hua ZHANG, Cong FENG, Hong JIANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Zi-Han LIU, Yu-Qi WANG, Xiao-Dan MEI, Fei WANG, Xian-Zhao YANG, Xiao-Dong LI, Feng JIANG, Jia-Yu ZHANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Han YUE, Hui ZENG, Kan DINGAbstractDendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book “Shen Nong’s Materia Medica”. It’s well known that bioactivities are usually related to the ingredients’ basis. Based on the previous research, Dendrobium species contain amino acid, sesquiterpenoids, alkaloids and polysaccharides. As the bioactive substances, carbohydrate shows extensive activities in antit...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Compounds of traditional Chinese medicine and neuropathic pain
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Shun-Hua LI, Lin LI, Ru-Nan YANG, Shang-Dong LIANGAbstractNeuropathic pain (NP) has become a serious global health issue and a huge clinical challenge without available effective treatment. P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention. Traditional Chinese medicine (TCM) contains multiple components which are effective in targeting different pathological mechanisms involved in NP. Different from traditional analgesics, which target a single pathwa...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Recent advances of long noncoding RNAs involved in the development of multiple sclerosis
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Qian-Wen LI, Wen LEI, Cong CHEN, Wei GUOAbstractGiven the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies, the discovery of novel and effective therapeutic targets have been in an urgent demand. Recent studies have revealed that long noncoding RNAs (lncRNAs) play crucial roles in the development of multiple sclerosis (MS), which provides a new opportunity of uncovering novel mechanism associated with the progression of MS. This review highlights the dysregulation of lncRNAs in ...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Mechanistic evaluation of gastro-protective effects of KangFuXinYe on indomethacin-induced gastric damage in rats
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Qi-Juan LI, Zhan-Guo WANG, Yu XIE, Qiao LIU, Hui-Ling HU, Yong-Xiang GAOAbstractKangFuXinYe (KFX), the ethanol extract of the dried whole body of Periplaneta americana, is a well-known important Chinese medicine preparation that has been used to treat digestive diseases such as gastric ulcers for many years in China. However, its therapeutic effect and mechanism are not yet well understood. Thus, the aim of this study was to investigate the gastro-protective effects of KangFuXinYe (KFX) in indomethacin-induced gastric d...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Zi-Tian WU, Zhuo-Qing LI, Wei SHI, Ling-Li WANG, Yan JIANG, Ping LI, Hui-Jun LIAbstractDiterpenoid lactones (DLs), a group of furan-containing compounds found in Dioscorea bulbifera L. (DB), have been reported to be associated with hepatotoxicity. Different hepatotoxicities of these DLs have been observed in vitro, but reasonable explanations for the differential hepatotoxicity have not been provided. Herein, the present study aimed to confirm the potential factors that contribute to varied hepatotoxicity of four repres...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Three new secoiridoid glycosides from the flower buds of Lonicera japonica
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Ran YANG, Hao HAO, Jia LI, Jing XUAN, Ming-Feng XIA, Yong-Qing ZHANGAbstractThree new secoiridoid glycosides, named lonijapoglycol A (1), aldosecolohanin C (2) and aldosecolohanin B (3), together with three known ones (4–6), have been isolated from the flower the buds of Lonicera japonica. All the structures were identified by spectroscopic analyses. Lonijapoglycol A (1) expressed significant anti-inflammatory activity to inhibit the release of β-glu-curonidase induced by platelet-activating factor in rat polymorphon...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Gui-Yang XIA, Ling-Yan WANG, Jing-Fang ZHANG, Yu-Zhuo WU, Guang-Bo GE, Ya-Nan WANG, Peng-Cheng LIN, Sheng LINAbstractPurpurolides D–F (1–3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, 13C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic cir...
Source: Chinese Journal of Natural Medicines - January 17, 2020 Category: Complementary Medicine Source Type: research

Endless exploration for natural products: dedicated to the 80th birthday of Prof. SUN Han-Dong
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Ling-Yi KONG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Difficulties in research of Chinese medicine polysaccharides
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Li-Feng LI, Tin-Long WONG, Quan-Bin HANAbstractPolysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and development of new drugs and health products. However, there are rarely successful cases. Here, based on the authors' own research experience, the difficulties and ch...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research