Two folate-derived analogues from an aqueous decoction of Uncaria rhynchophylla

Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Yue WANG, Qing-Lan GUO, Ruo-Fei LI, Cheng-Bo XU, Cheng-Gen ZHU, Jian-Gong SHIAbstractTwo new folate-derived analogues, named uncarophyllofolic acids A (1) and B (2), respectively, were isolated from the Uncaria rhynchophylla hook bearing stem (Gouteng in Chinese). The distinct stereochemical structures of 1 and 2 were determined by spectroscopic data analysis in combination with acidic hydrolysis and Marfey's derivatization, along with comparison of their specific rotation and Cotton effect (CE) data with those of the biogenetically related known derivatives as well as theoretical calculations of electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway of 1 and 2, associating to folate metabolism and the previously reported orychophragines A–C from Orychophragmus violaceus, is discussed.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research