Two symmetrical unsaturated acids isolated from Viscum album

Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Duo CAO, Li-Qing WANG, Xiao-Min HAN, Hui-Rui GUAN, Meng LEI, Ya-Hui WEI, Liang CHENG, Pei-Ming YANG, Zheng-Liang SUN, Wen GAO, Jia-Kun DAIAbstractIn the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 – 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L−1, and the SC50 of 4.34 and 8.22 μmol·L−1, respectively.
Source: Chinese Journal of Natural Medicines - Category: Complementary Medicine Source Type: research